CCAPD: Alignment of Alcohol Dehydrogenase 1 (ADH1), Beta Isozyme for primates

10 20 30 40 50 60 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus sTAGKVIKCKAAVlWExkKPfSIEEVEVAPPQAhEVRIKMVAtGICrSDDHvVsGxLxxx ==================================================================================================== * GADUS_MORHUA aTvGKVIKCKAAVaWEanKPlvIEEIEVdvPhANEIRIKIIATGVChTDlyhLfegkhkd * Danio_rerio aTAGKVIKCRAAVaWEpKaPlmMEEIEVAPPQegEIRIKVIATGLChTDlyhLvdg-dkr * Oryzias_latipes aTAGKVIKCKAAVaWEpnKPlvIEDIEVAPPQANEVRIKIVATGVChTDlyhLfegMhkd ==================================================================================================== * HUMAN STAGKVIKCKAAVLWEvKKPFSIEDVEVAPPKAyEVRIKMVAvGICRTDDHVVSGnLv-t * HORSE STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1HDYA_Human STAGKVIKCKAAVLWEvKKPFSIEDVEVAPPKAyEVRIKMVAvGIChTDDHVVSGnLv-t * 1HDZA_Human STAGKVIKCKAAVLWEvKKPFSIEDVEVAPPKAyEVRIKMVAvGICgTDDHVVSGnLv-t * 1HTBA_Human STAGKVIKCKAAVLWEvKKPFSIEDVEVAPPKAyEVRIKMVAvGICRTDDHVVSGnLv-t * 1A71A_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1AXEA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1AXGA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1JU9A_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1MGOA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1N8KA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1QLHA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1QV6A_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDqVVSGtLv-t * Apteryx_australis STAGKVIKCKAAVLWEpKKPFSIEEVEVAPPKAHEVRIKILATGICRSDDHVITGaLv-r * Canis_lupus STAGKVIKCKAAVLWElKKPFSIEEVEVAPPKAHEVRIKMVASGICRSDDHVVTGaLv-v * Coturnix_coturnix STAGKVIKCKAAVLWEanKPFSLEEVEVAPPKAHEVRIKIVATGICRSDDHVVTGaLa-m * Chicken STvGKVIKCKAAVLWEanKPFSLEEVEVAPPKAHEVRIKIVATGICRSDDHVVTGaLa-m * Mouse STAGKVIKCKAAVLWElhKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHVVSGtLv-t * Rabbit STAGKVIKCKAAVLWQlnKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHaVTGsIa-v * Pan_troglodytes STAGKVIKCKAAVLWEvKKPFSIEDVEVAPPKAyEVRIKMVAvGICRTDDHVVSGnLv-t * Papio_hamadryas STAGKVIKCKAAVLWEvKKPFSIEDVEVAPPKAyEVRIKMVAvGICRTDDHVVSGnLv-s * X_laevis aTAGKVIKCKAAIaWgpKQPlTIEDIEVAPPKAHEVRVKIVATGICRSDDHVLSGaIsdm * X_tropicalis aTAGKVIKCKAAVaWgpKQPlTIEDIEVAPPKAHEVRVKIVATGICRSDDHVLSGaIsdm * Rat-ADH1 STAGKVIKCKAAVLWEphKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHaVSGsLf-t * Rat-Q8K571 STAGKVIKCKAAVLWEphKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHaVSGsLf-t * Struthio_camelus-ADH1 STAGKVIKCKAAVLWEpKKPFSIEEVEVAPPKAHEVRVKIIATGICRSDDHVISGvLv-m * Struthio_camelus-ADH1_VAR STAGKVIKCKAAVLWEpKKPFSIEEVEVAPPKAHEVRVKIIATGICRSDDHVISGvLv-m * Alligator_mississippiensis-ADH1 STAGKVIKCKAAItWEiKKPFSIEEIEVAPPKAHEVRIKILATGICRSDDHVtaGlLt-m * Alligator_mississippiensis-ADH1_VAR_1 STAGKVIKCKAAItWEiKKPFSIEEIEVAPPKAHEVRIKILATGICRSDDHVtaGlLt-m * Alligator_mississippiensis-ADH1_VAR_2 STAGKVIKCKAAItWEiKKPFSIEEIEVAPPKAHEVRIKILATGICRSDDHVtaGlLt-m * Human-ADH1B_VAR_2 STAGKVIKCKAAVLWEvKKPFSIEDVEVAPPKAyEVRIKMVAvGICRTDDHVVSGkLv-t * Human-ADH1B_VAR_3 STAGKVIKCKAAVLWEvKKPFSIEDVEVAPPKAyEVRIKMVAvGICRTDDHVVSGnLv-s ==================================================================================================== Consensus sTAGKVIKCKAAVlWExkKPfSIEEVEVAPPQAhEVRIKMVAtGICrSDDHvVsGxLxxx 70 80 90 100 110 120 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus pxPvILGHEaAGIVESIGEGVSslRPGDKVIPLWxPQCGKCkxCkNpKsNxClKxNDLxx ==================================================================================================== * GADUS_MORHUA gfPVVLGHEgAGIVESVGpGVTefQPGEKVIPLFisQCGECRfCQSPKTNqCVK-gwa-n * Danio_rerio gfPVVLGHEsAGVVESVGpGVTdyKPGDKVIPLFlsQCGKCKfCKcPKTNlCes-Swa-t * Oryzias_latipes gfPaVLGHEgAGIVESVGpGVSefQPGDRVIPLFisQCrECRfCKSPKTNqCeK-gwa-a ==================================================================================================== * HUMAN PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRvCKNPESNyCLK-NDL-g * HORSE PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfCLK-NDL-s * 1HDYA_Human PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRvCKNPESNyCLK-NDL-g * 1HDZA_Human PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRvCKNPESNyCLK-NDL-g * 1HTBA_Human PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRvCKNPESNyCLK-NDL-g * 1A71A_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLWtPQCGKCRvCKHPEgNfCLK-NDL-s * 1AXEA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLWtPQCGKCRvCKHPEgNfCLK-NDL-s * 1AXGA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfCLK-NDL-s * 1JU9A_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfCLK-NDL-s * 1MGOA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLatPQCGKCRvCKHPEgNfCLK-NDL-s * 1N8KA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfCLK-NDL-s * 1QLHA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfCLK-NDL-s * 1QV6A_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfCLK-NDL-s * Apteryx_australis PfPIILGHEAAGVVESVGEGVTSVKPGDKVIPLFvPQCGECsaClStKgNlCsK-NDI-g * Canis_lupus PlPIILGHEAAGIVESIGEGVTTVKPGDKVIPLFtPQCGKCnvCKHPQgNlCVK-NDL-s * Coturnix_coturnix PfPVILGHEAAGVVESVGEkVTlLKPGDaVIPLFvPQCGECRsClStKgNlCIK-NDLss * Chicken PfPIILGHEAAGVIESVGEkVTSLKPGDaVIPLFvPQCGECRsClStKgNlCIK-NDLss * Mouse PlPaVLGHEgAGIVESVGEGVTcVKPGDKVIPLFsPQCGECRiCKHPESNfCsR-SDL-l * Rabbit PlPVILGHEAAGIVESIGEGVTTVKPGDKVIPLFtPQCGKCRiCKHPESNfCLi-NDL-g * Pan_troglodytes PlPaILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRvCKNPESNyCLK-NDL-g * Papio_hamadryas PlPaILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRvCKSPEgNyCVK-NDL-s * X_laevis kfPaILGHEgAGIVESVGEGVkNIKPGDKVIPLFvPQCGECRsCtNsRSNlCdK-HDI-g * X_tropicalis kfPaILGHEgAGIVESVGEGVkNIKPGDKVIPLFvPQCGECRcCtNvRSNlCdK-HDI-g * Rat-ADH1 PlPaVLGHEgAGIVESIGEGVTcVKPGDKVIPLFsPQCGKCRiCKHPESNlCcQtkNL-t * Rat-Q8K571 PlPaVLGHEgAGIVESIGEGVTcVKPGDKVIPLFsPQCGKCRiCKHPESNlCcQtkNL-t * Struthio_camelus-ADH1 PfPIILGHEAAGVVESVGEGVTSVKPGDKVIPLFvPQCGECsvClStKgNlCrK-NDI-g * Struthio_camelus-ADH1_VAR PfPIILGHEAAGVVESVGEGVTSVKPGDKVIPLFvPQCGECsvClStKgNlCcK-NDI-g * Alligator_mississippiensis-ADH1 PlPMILGHEAAGVVEStGEGVTSLKPGDKVIPLFvPQCGECmpClksngNlCIR-NDL-g * Alligator_mississippiensis-ADH1_VAR_1 PlPMILGHEAAGVVEStGEGVTSLKPGDKVIPLFvPQCGECmpClksngNlCIR-NDL-g * Alligator_mississippiensis-ADH1_VAR_2 PlPMILGHEAAGVVEStGEGVTSLKPGDKVIPLFvPQCGECmpClksngNlCIR-NDL-g * Human-ADH1B_VAR_2 PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRvCKNPESNyCLK-NDL-g * Human-ADH1B_VAR_3 PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRvCKNPESNyCLK-NDL-g ==================================================================================================== Consensus pxPvILGHEaAGIVESIGEGVSslRPGDKVIPLWxPQCGKCkxCkNpKsNxClKxNDLxx 130 140 150 160 170 180 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxpxxxgxmxdgTsRFTCRGKxIhnFLgTSTFSQYTVVNExaVAKIDaaaPLEKVCLIGC ==================================================================================================== * GADUS_MORHUA esPdvmsp---keTRFTCKGRkVlqFLGTSTFSQYTVVNQiAVAKIDpsAPLDtVCLLGC * Danio_rerio kyhdimae---pTSRFTCRGQtIlqFMGTSTFSEYTVINQnAVAKIDenAPLDRVfLLGC * Oryzias_latipes dhydvmal---adSRFTCKGKkVlqFMGaSTFSEYTVMNQiAVAKIDpAAPLDKVCLLGC ==================================================================================================== * HUMAN -nP-r-GtLqDGTrRFTCRGKpIHHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * HORSE -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1HDYA_Human -nP-r-GtLqDGTrRFTCRGKpIHHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * 1HDZA_Human -nP-r-GtLqDGTrRFTCRGKpIHHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * 1HTBA_Human -nP-r-GtLqDGTrRFTCRGKpIHHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * 1A71A_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1AXEA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1AXGA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1JU9A_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1MGOA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1N8KA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1QLHA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1QV6A_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * Apteryx_australis -sa-s-GlMpDGTTRFTCKGKaIHHFIGTSTFTEYTVVHEtAVAKIaAAAPLEKVCLIGC * Canis_lupus -kP-r-GtLqDGTiRFTCRGKpIyHFLGiSTFSQYTVVDEfsVAKIDAAsPLEKVCLIGC * Coturnix_coturnix -sP-t-GlMaDGTTRFTCKGKaIHHFIGTSTFTEYTVVHEtAaAKIDsAAPLEKVCLIGC * Chicken -sP-t-GlMaDGTTRFTCKGKaIHHFVGTSTFTEYTVVHEtAaAKIDsAAPLEKVCLIGC * Mouse -mP-r-GtLrEGTSRFSCKGKqIHNFIsTSTFSQYTVVDDiAVAKIDgAsPLDKVCLIGC * Rabbit -kP-k-GmLlDGTSRFTCKGKpIHHFIGTSTFSQYTVVDEiAVAKIDAAAPLEKVCLIGC * Pan_troglodytes -nP-r-GtLqDGTrRFTCRGKpIHHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * Papio_hamadryas -nP-r-GtLqDGTrRFTCRGKpIHHFVGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * X_laevis -py-i-GlLlDkTSRiTCKGKpVyNFLsTSTFTEYTVLDEicVAKIDdnAPLDKVCLIGC * X_tropicalis -py-r-GlMlDnTNRFTCKGnpVytFLsTSTFTEYTVLDEicVAKIDdnAPLDKVCLIGC * Rat-ADH1 -qP-k-GaLlDGTSRFSCRGKpIHHFIsTSTFSQYTVVDDiAVAKIDAAAPLDKVCLIGC * Rat-Q8K571 -qP-k-GaLlDGTSRFSCRGKpIHHFIsTSTFSQYTVVDDiAVAKIDAAAPLDKVCLIGC * Struthio_camelus-ADH1 -pa-s-alMpDGTSRFTCKGKaIHHFaGTSTFTEYTVLHEtAVAKIDAAAPLEKVCLIGC * Struthio_camelus-ADH1_VAR -pa-s-alMpDGTSRFTCKGKaIHHFaGTSTFTEYTVLHEtAVAKIDAAAPLEKVCLIGC * Alligator_mississippiensis-ADH1 -sP-s-GlMaDGTSRFTCKGKdIHHFIGTSTFTEYTVVHEtAVARIDAAAPLEKVCLIGC * Alligator_mississippiensis-ADH1_VAR_1 -sP-s-GlMaDGTSRFTCKGKdIHHFIGTSTFTEYTVVHEtAVARIDAAAPLEKVCLIGC * Alligator_mississippiensis-ADH1_VAR_2 -sP-s-GlMaDGTSRFTCKGKdIHHFIGTSTFTEYTVVHEtAVARIDAAAPLEKVCLIGC * Human-ADH1B_VAR_2 -nP-r-GtLqDGTrRFTCRGKpIHHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * Human-ADH1B_VAR_3 -nP-r-GtLqDGTrRFTCRGKpIHHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC ==================================================================================================== Consensus xxpxxxgxmxdgTsRFTCRGKxIhnFLgTSTFSQYTVVNExaVAKIDaaaPLEKVCLIGC 190 200 210 220 230 240 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus GFSTGYGsAVkxAKVxpGSTCAVFGLGGVGLSvIMGCKaAGAxRIIaVDiNkEKFaKAKE ==================================================================================================== * GADUS_MORHUA GvSTGFGaAVntAKVePGSTCAVFGLGaVGLaaVMGChsAGAkRIIAVDLNpDKFeKAKv * Danio_rerio GiTTGYGaAVntAgVtPGSvCAVFGLGaVGLaaVMGCKnAGAsRIfAVDINEKKFeKAKv * Oryzias_latipes GvcTGFGaAVntAKVePGSTCAVFGLGaVGLaaVMGCKfAGAkRIfAVDtNpEKaeKARv ==================================================================================================== * HUMAN GFSTGYGSAVnvAKVtPGSTCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE * HORSE GFSTGYGSAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1HDYA_Human GFSTGYGSAVnvAKVtPGSTCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE * 1HDZA_Human GFSTGYGSAVnvAKVtPGSTCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE * 1HTBA_Human GFSTGYGSAVnvAKVtPGSTCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE * 1A71A_Horse GFSTGYGSAVKvAKVtqGSTCAVFGLGGaGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1AXEA_Horse GFSTGYGSAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1AXGA_Horse GFSTGYGSAVKvAKVtqGSTCAVFGLGGaGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1JU9A_Horse GFSTGYGSAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1MGOA_Horse GFSTGYGSAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1N8KA_Horse GFSTGYGSAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1QLHA_Horse GFSTGYGSAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1QV6A_Horse GFSTGYGSAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDRFAKAKE * Apteryx_australis GFSTGYGaAVQtAKVePGSTCAVFGLGGVGLSVVMGCKAAGAsRIIAIDINKDKFAKAKE * Canis_lupus GFSTGYGSAVnvAKVtPGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * Coturnix_coturnix GFSTGYGavLQtAKVePGSTCAVFGLGGVGLSVVMGCKAAGAsRIIAIDINKDKFAKAKE * Chicken GFSTGYGavLQtAKVeaGSTCAVFGLGGVGLSVVMGCKAAGAsRIIAVDINKDKFAKAKE * Mouse GFSTGYGSAVKvAKVtPGSTCAVFGLGGVGLSVIIGCKAAGAaRIIAVDINKDKFAKAKE * Rabbit GFSTGYGSAVKvAKVtPGSTCAVFGLGGVGLSVIMGCKAAGAsRIIAVDINKDKFpKAKE * Pan_troglodytes GFSTGYGSAVnvAKVtPGSTCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE * Papio_hamadryas GFSTGYGSAVnvAKVtPGSvCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE * X_laevis GFSTGYGSAVKtAKVePGSSCAVFGLGGVGLSVLIGCKvAGAaKIIgVDtNpDKFAKAKE * X_tropicalis GFSTGYGSAVKiAKVeqGSSCAVFGLGGVGLSVLIGCKvAGAsKIIgVDtNsDKFAKAKE * Rat-ADH1 GFSTGYGSAVQvAKVtPGSTCAVFGLGGVGLSVVIGCKtAGAaKIIAVDINKDKFAKAKE * Rat-Q8K571 GFSTGYGSAVQvAKVtPGSTCAVFGLeGVGLSVVIGCKtAGAaKIIAVDINKDKFAKAKE * Struthio_camelus-ADH1 GFSTGYGaALQtAKVePGSTCAVFGLGGVGLSVVMGCKAAGAsRIIgVDINKDKFAKAKE * Struthio_camelus-ADH1_VAR GFSTGYGaALQtAKVePGSTCAVFGLGGVGLSVVMGCKAAGAsRIIgVDINKDKFAKAKE * Alligator_mississippiensis-ADH1 GFSTGYGaAVKdAKVePGSTCAVFGLGGVGLStIMGCKAAGAsRIIgIDINKDKFAKAKE * Alligator_mississippiensis-ADH1_VAR_1 GFSTGYGaAVKdAKVePGSTCAVFGLGGVGLStIMGCKAAGAsRIIgIDINKDKFAKAKE * Alligator_mississippiensis-ADH1_VAR_2 GFSTGYGaAVKtAKVePGSTCAVFGLGGVGLStIMGCKAAGAsRIIgIDINKDKFAKAKE * Human-ADH1B_VAR_2 GFSTGYGSAVnvAKVtPGSTCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE * Human-ADH1B_VAR_3 GFSTGYGSAVnvAKVtPGSTCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE ==================================================================================================== Consensus GFSTGYGsAVkxAKVxpGSTCAVFGLGGVGLSvIMGCKaAGAxRIIaVDiNkEKFaKAKE 250 260 270 280 290 300 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus LGATECVNPqDYxKPIxEVLxEMSnxgGVDFSFEvIGrlEtMxxaLxsChxxyGvSVIVG ==================================================================================================== * GADUS_MORHUA fGATDfVNPnDhsEPIsQVLsKMTN-GGVDFSlEcVGnVgvMrnALeSClkgWGVSVLVG * Danio_rerio fGATDfLNPKaFnKPIsEVLiEMTNgGGVDFSiEctGntEvMrsALeSCakgWGVSVVVG * Oryzias_latipes fGATDfVNPKDYnKPIsKVLaEMTN-GGVDYSlEcVGnVDvMrsALeSCmkgWGVSVVVG ==================================================================================================== * HUMAN LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * HORSE VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1HDYA_Human LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * 1HDZA_Human LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * 1HTBA_Human LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * 1A71A_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1AXEA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1AXGA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1JU9A_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIsG * 1MGOA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1N8KA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVItG * 1QLHA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVa * 1QV6A_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * Apteryx_australis LGATDCVNPKDFtKPIhEVLmEMTg-lGVDYSFEVIGhtETMaaALaSCHfnYGVSVILG * Canis_lupus VGATECISPQDYkEPIqEVLkEISg-GsVDFSFEVIGRLDTMvaALscCqesYGVSVIVG * Coturnix_coturnix LGATECVNPKDFkKPIhEVLtEMTg-kGVDYSFEVIGRIETMteALaSCHynYGVSVIVG * Chicken LGATECINPKDFkKPIhEVLtEMTg-qGVDYSFEVIGRIETMtaALaSCHnnYGVSVIVG * Mouse LGATECINPQDYsKPIqEVLqEMTD-GGVDFSFEVIGRLDTMtsALlSCHaacGVSVVVG * Rabbit VGATECINPQDYkKPIqEVIqEISD-GGVDFSFEVIGRLDTVvaALlSCHgacGtSVIVG * Pan_troglodytes LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * Papio_hamadryas LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * X_laevis LGATECINPnDYkEPIhEVLaKMSN-GGLDYTFEcIGntKvMesALlatHfgcGtSVIVG * X_tropicalis LGATECINPnDYnEPIhEVLaKISD-GGLDYTFEcIGntKvMesALkatHfgcGtSVIVG * Rat-ADH1 LGATDCINPQDYtKPIqEVLqEMTD-GGVDFSFEVIGRLDTMtsALlSCHsacGVSVIVG * Rat-Q8K571 LGATDCINPQDYtKPIqEVLqEMTD-GGVDFSFEVIGRLDTMtsALlSCHsacGVSVIVG * Struthio_camelus-ADH1 LGATDCVNPKDFtKPIhEVLmEMTg-lGVDYSFEVIGhtETMaaALaSCHfnYGVSVIVG * Struthio_camelus-ADH1_VAR LGATDCVNPKDFtKPIhEVLmEMTg-lGVDYSFEVIGhtETMaaALaSCHfnYGVSVIVG * Alligator_mississippiensis-ADH1 LGATECINPlDckKPIqEVLsEMTg-GGVDYSFEVIGRIDTMtaALacCqdnYGtSVIVG * Alligator_mississippiensis-ADH1_VAR_1 LGATECINPlDckKPIqEVLsEMTg-GGVDYSFEVIGRIDTMtaALacCqdnYGtSVIVG * Alligator_mississippiensis-ADH1_VAR_2 LGATECINPlDckKPIqEVLsEMTg-GGVDYSFEVIGRIDTMtaALacCqdnYGtSVIVG * Human-ADH1B_VAR_2 LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * Human-ADH1B_VAR_3 LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG ==================================================================================================== Consensus LGATECVNPqDYxKPIxEVLxEMSnxgGVDFSFEvIGrlEtMxxaLxsChxxyGvSVIVG 310 320 330 340 350 360 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus VppxxqnLSmNPMlLlsGRTWKGaIFGGFKSKDxVPKLVADFMaKKfxLDxLITHxLpfe ==================================================================================================== * GADUS_MORHUA wt-dlhDVatrPIqLIaGRTWKGsMFGGFKgKDgVPKMVkaYLdKKvkLDefITHrMPlE * Danio_rerio wt-nvQDfSakPIqLIyGKTWKGsLFGGFKcKDsVPKLVrDYMsgKimLDefITHkMnlE * Oryzias_latipes wt-dkhDfSarPIqLIaGRTWKGtLFGGFKSKDgVPQMVkaYMeRKvkLDefITHnMtlt ==================================================================================================== * HUMAN VPPasQNLSINPMLLLTGRTWKGAVYGGFKSKEgIPKLVADFMAKKFsLDaLITHvLPFE * HORSE VPPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1HDYA_Human VPPasQNLSINPMLLLTGRTWKGAVYGGFKSKEgIPKLVADFMAKKFsLDaLITHvLPFE * 1HDZA_Human VPPasQNLSINPMLLLTGRTWKGAVYGGFKSKEgIPKLVADFMAKKFsLDaLITHvLPFE * 1HTBA_Human VPPasQNLSINPMLLLTGRTWKGAVYGGFKSKEgIPKLVADFMAKKFsLDaLITHvLPFE * 1A71A_Horse VPPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1AXEA_Horse VPPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1AXGA_Horse VPPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1JU9A_Horse VPPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1MGOA_Horse VPPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1N8KA_Horse VPPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1QLHA_Horse VtPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1QV6A_Horse VPPdsQNLSMNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * Apteryx_australis VPPaaEkISfDPMLLfSGRTWKGsVFGGWKSKDaVPKLVADYMeKKFvLEpLITHtLPFi * Canis_lupus VPPnsQSLSMNPMLLLTGRSWKGAIFGGFKSKDsVPKLVADFMAKKFpLEsLITHvLPFE * Coturnix_coturnix VPPaaQkISfDPMLIfSGRTWKGsVFGGWKSKDaVPKLVADYMkKKFvLDpLITHtLPFt * Chicken VPPaaQkISfDPMLIfSGRTWKGsVFGGWKSKDaVPKLVADYMkKKFvLDpLITHtLPFt * Mouse VPPnaQNLSMNPMLLLlGRTWKGAIFGGFKSKDsVPKLVADFMAKKFpLDpLITHvLPFE * Rabbit VPPdsQSLTVNPMLLLSGRTWKGAIFGGFKSKDsVPKLVADFMAKKFsLDpLITNvLPFE * Pan_troglodytes VPPasQNLSINPMLLLTGRTWKGAVYGGFKSKEgIPKLVADFMAKKFsLDaLITHvLPFE * Papio_hamadryas VPPdsQNLSINPMLLLTGRTWKGAVYGGFKSREgIPKLVADFMAKKFsLDaLITHvLPFE * X_laevis LaPasarVlVDPMeMLTGRTlKGALFGGWKSRDdVPKLVADFMAKKFeLDgLITHrstlD * X_tropicalis LaPasarVSVDPMeMLTGRTlKGALFGGWKSRDeVPQLVADFLAKKFeLDgLITHrstlD * Rat-ADH1 VPPsaQSLSVNPMsLLlGRTWKGAIFGGFKSKDaVPKLVADFMAKKFpLEpLITHvLPFE * Rat-Q8K571 VPPsaQSLSVNPMsLLlGRTWKGAIFGGFKSKDaVPKLVADFMAKKFpLEpLITHvLPFE * Struthio_camelus-ADH1 VPPaaEkLSfDPMLLfSGRTWKGsVFGGWKSKDsVPKLVADYMeKKFvLDpLITHtLPFh * Struthio_camelus-ADH1_VAR VPPaaEkLSfDPMLLfSGRTWKGsVFGGWKSKDsVPKLVADYMeKKFvLDpLITHtLPFh * Alligator_mississippiensis-ADH1 VPPasEkITfNPMMLfTGRTWKGsVFGGWKSKEsVPKLVADYMeKKinLDgLITHtLPFD * Alligator_mississippiensis-ADH1_VAR_1 VPPasEkITfNPMMLfTGRTWKGtVFGGWKSKEsVPKLVADYMeKKinLDgLITHtLPFD * Alligator_mississippiensis-ADH1_VAR_2 VPPasEkITfNPMMLfTGRTWKGsVFGGWKSKEsVPKLVADYMeKKinLDgLITHtLPFD * Human-ADH1B_VAR_2 VPPasQNLSINPMLLLTGRTWKGAVYGGFKSKEgIPKLVADFMAKKFsLDaLITHvLPFE * Human-ADH1B_VAR_3 VPPasQNLSINPMLLLTGRTWKGAVYGGFKSKEgIPKLVADFMAKKFsLDaLITHvLPFE ==================================================================================================== Consensus VppxxqnLSmNPMlLlsGRTWKGaIFGGFKSKDxVPKLVADFMaKKfxLDxLITHxLpfe 370 380 390 400 410 420 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus KINEgFDLLRsGESIRTILsfx ============================================================== * GADUS_MORHUA sVNDaiDLMKhGKcIRTVLSle * Danio_rerio QVNDaiNLMKTGQgIRTIMTvs * Oryzias_latipes QVNEaiELMKrGgcIRTVLSvs ============================================================== * HUMAN KINEGFDLLhSGKSIRTVLTF- * HORSE KINEGFDLLRSGESIRTILTF- * 1HDYA_Human KINEGFDLLhSGKSIRTVLTF- * 1HDZA_Human KINEGFDLLhSGKSIRTVLTF- * 1HTBA_Human KINEGFDLLhSGKSIcTVLTF- * 1A71A_Horse KINEGFDLLRSGESIRTILTF- * 1AXEA_Horse KINEGFDLLRSGESIRTILTF- * 1AXGA_Horse KINEGFDLLRSGESIRTILTF- * 1JU9A_Horse KINEGFDLLRSGESIRTILTF- * 1MGOA_Horse KINEGFDLLRSGESIRTILTF- * 1N8KA_Horse KINEGFDLLRSGESIRTILTF- * 1QLHA_Horse KINEGFDLLRSGESIRTILTF- * 1QV6A_Horse KINEGFDLLRSGESIRTILTF- * Apteryx_australis KINEGFDLLRkGKSIRSVLvF- * Canis_lupus KINEGFDLLRSGKSIRTVLTF- * Coturnix_coturnix KINEGFDLLRTGKSIRTVLvl- * Chicken KINEGFDLLRTGKSIRSVLvl- * Mouse KINEaFDLLRSGKSIRTVLTF- * Rabbit KINEGFDLLRSGKSIRTILTF- * Pan_troglodytes KINEGFDLLhSGKSIRTVLTF- * Papio_hamadryas KINEGFDLLRSGKSIRTVLTF- * X_laevis KINEGFDLLRkGDSIRTILqis * X_tropicalis KINEGFDLLRkGDSIRTILqis * Rat-ADH1 KINEaFDLLRaGKSIRTVLTF- * Rat-Q8K571 KINEaFDLLRaGKSIRTVLTF- * Struthio_camelus-ADH1 KINEGFDLLRTGKSIRSVLlF- * Struthio_camelus-ADH1_VAR KINEGFDLLRTGKSIRSVLlF- * Alligator_mississippiensis-ADH1 KINEGFELLRTGKSIRSVLTF- * Alligator_mississippiensis-ADH1_VAR_1 KINEGFELLRTGKSIRSVLTF- * Alligator_mississippiensis-ADH1_VAR_2 KINEGFELLRTGKSIRSVLTF- * Human-ADH1B_VAR_2 KINEGFDLLhSGKSIRTVLTF- * Human-ADH1B_VAR_3 KINEGFDLLhSGKSIRTVLTF- ============================================================== Consensus KINEgFDLLRsGESIRTILsfx

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