CCAPD: Alignment of Ubiquitin-conjugating enzymes, E2 family

10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus aasRRLxKELeeIRengmkNxfrdiqVNEsNLltwqGliVpxdnpPYDkGaFrIEInfPaEYPFKPPKIsFkTKI ==================================================================================================== * HUMAN AASRRLmKELEEIRKcGMKN-FRNIQVDEaNLLTWQGLIVP-DNPPYDKGAFRIEINFPAEYPFKPPKITFKTKI * Anopheles_gambiae AATRRLqKELaDIRsSGMKS-FRDIlVDETNLLlWtGLIVP-DNvPYNKGAFRIEINFPAEYPFKPPKISFKTKI * Apis_mellifera AATRRLqKELgDLRaSaMKN-FtNIQVDESNILTWQGLILP-DNPPYNKGAFRIEINFPAEYPFKPPKINFKTKI * Bombyx_mandarina AATRRLqKELnDIRQSGLKS-FRDIQVDESNILTWQGLIVP-DNPPYNKGAFRIEINFPAEYPFKPPKISFKTKI * Danio_rerio AASRRLhKELDEIRKSGMKN-FRNIQVDESNILTWQGLIVP-DNPPYDKGAFRIEItFPAEYPFKPPKITFKTKI * D_melanogaster tApRRLrKELsDLQgNaLKS-FRDIKaDDdNLLrWtGLIVP-DNPPYNKGAFRIEINFPAEYPFKPPKINFKTRI * D_pseudoobscura tApRRLrKELcDLQDNtLKS-FRDIKaDDeNLLrWtGLIVP-DNPPYNKGAFRIEINFPAEYPFKPPKINFKTRI * Ixodes_scapularis AATRRLqKELtEIKKaGgKS-FREIQVDENNLLTWQGLIVP-ENvPYNRGAFRIEINFPAEYPFKPPKITFRTKI * Pan_troglodytes AASRRLmKELEEIRKcGMKN-FRNIQVDEaNLLTWQGLIVP-DNPPYDKGAFRIEINFPAEYPFKPlKITFKTKI * Pongo_pygmaeus AASRRLmKELEEIRKcGMKN-FRNIRVDEaNLLTWQGLIVP-DNPPYDKGAFRIEINFPAEYPFKPPKITFKTKI * Schistosoma_japonicum AAvRRLkKEyEtLinSsIKNviRNVtyDEpNfLTWtGyIVl-DePPYNKGAFKIEItFPvEYPFKPPKViFKTRI * Tetraodon_nigroviridis sASRRLaKELEEIRKSGMKN-FRNIQVeESNLLSWQGLIVP-DNPPYDKGAFRIEIiFPtEYPFKPPKITFKTKI * Tribolium_castaneum AATRRLqKELgDIRnSGLKS-FRDIQVDETNILTWQGLIVP-DNPPYNKGAFKIEINFPAEYPFKPPKITFKTKI * X_laevis AASRRLmKELEEIRKSGMKN-FRNIQVDEaNLLTWQGLIVP-DNPPYDKGAFRIEINFPAEYPFKPPKITFKTKI * X_tropicalis AASRRLmKELEEIRKtGMKN-FRNIQVeDSNLLTWQGLIVP-DNPPYDKGAFRIEINFPAEYPFKPPKITFKTKI ==================================================================================================== * S_CEREVISIAE sraKRImKEIQaVKDDpaaH-itlefVSESDIhhlKGtfLgppgtPYEgGkFvVDIevPmEYPFKPPKMqFdTKV * Candida_glabrata sraKRImKELQaVKDDpeaN-islefVSESDIhhlKGsfLgppgtPYEgGkFiVDIevPmEYPFKPPKMkFdSKV * Eremothecium_gossypii sraKRLmKEIQsVKDDpdaN-islafVSESDIhhlKGtfLgppgtPYhgGtFiVDIqvPlEYPFKPPKMqFdTKV * Kluyveromyces_lactis lrSKRIlKEIQaVKEDpeaq-ielkfVNESDIhhmKGsfIgpsgtPYEgGkFvVDINiPvEYPYKPPQMkFdTKV ==================================================================================================== Consensus aasRRLxKELeeIRengmkNxfrdiqVNEsNLltwqGliVpxdnpPYDkGaFrIEInfPaEYPFKPPKIsFkTKI 80 90 100 110 120 130 140 150 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus YHPNIdexkGqVCLpVIsaDSWkPatktEqvIqsLiALVndPQPehPlrAELAEeYxKDRKkFxKnAeeYTKkxx ==================================================================================================== * HUMAN YHPNIDE-KGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYsKDRKKFcKNAEEFTKKyg * Anopheles_gambiae YHPNIDE-KGQVCLPIISAENWKPATKTDQVIQaLIeLVNDPEPEHPLRADLAEEFlKDRKKFtKNAEEhTRKhs * Apis_mellifera YHPNVDE-KGQVCLPIISAENWKPATKTDQVVQaLIALVNDPEPEHPLRADLAEEFlKDRKKFlKNAEEFTKKha * Bombyx_mandarina YHPNIDE-KGQVCLPIISAENWKPATKTDQVIQaLVALVNDPEPEHPLRAELAEEFlKDRKKFtKNAEEFTKKhs * Danio_rerio YHPNIDE-KGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYsKDRKKFfKNAEEFTKKhg * D_melanogaster YHPNIDE-KGQVCLPIIStENWKPATRTDQVVQaLVdLINDPEPEHPLRAELAEEFlKDRKKFvKNAEDYTKKhs * D_pseudoobscura YHPNIDE-KGQVCLPIIStENWKPATRTEQVVQaLIALINDPEPEHPLRAELAEEFlKDRKKFvKNAEDYTKKhs * Ixodes_scapularis YHPNIDE-KGQVCLPIISpDNWKPATKTDQVIQaLIALVNDPEPEHPLRADLAEEYsKDRKKFlKNAEDFTKKhs * Pan_troglodytes YHPNIDE-KGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYsKDRKKFcKNAEEFTKKyg * Pongo_pygmaeus YHPNIDE-KGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYsKDRKKFcKNAEEFTKKyg * Schistosoma_japonicum YHPNIDE-KGQICLPIINpENWKPATKvEhVIQaLVAMLHaPEvEHaLRsDLAEEYaKDpKKFfKNAEEFTRKya * Tetraodon_nigroviridis YHPNIDE-KGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYsKDRKKFlKNAEEFTKKhg * Tribolium_castaneum YHPNIDE-KGQVCLPIISAENWKPATKTDQVIQaLVALVNEPEPEHPLRADLAEEYiKDKKKFtKNAEEFTKKhs * X_laevis YHPNIDE-KGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYsKDRKKFcKNAEEFTKKyg * X_tropicalis YHPNIDE-KGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYsKDRKKFcKNAEEFTKKyg ==================================================================================================== * S_CEREVISIAE YHPNIssvtGaICLdIL-kNaWsPvitlKsaLiSLqALLqsPEPndPqdAEVAQhYlRDREsFnKtAalWTRlya * Candida_glabrata YHPNIssvtGaICLdIL-kNaWsPvitlKsaLiSLqALLqsPEPndPqdAEVAQhYlRDRQsFdKtAalWTKlya * Eremothecium_gossypii YHPNIssvtGaICLdIL-kNSWsPvltlKtsLiSLqALLqsPEPndPqdAEVAKhYlsDRasFdRtAalWTKtya * Kluyveromyces_lactis YHPNVssvtGaICLdIL-kNaWtPvitlKsaLiSLqALLqsPEPndPqdAQVAKhYltDKKsFdEtAalWTRtya ==================================================================================================== Consensus YHPNIdexkGqVCLpVIsaDSWkPatktEqvIqsLiALVndPQPehPlrAELAEeYxKDRKkFxKnAeeYTKkxx 160 170 180 190 200 210 220 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus ekrpxdxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== * HUMAN EKRPvD--------------------------------------------------------------------- * Anopheles_gambiae EKRPe---------------------------------------------------------------------- * Apis_mellifera EKRresssne----------------------------------------------------------------- * Bombyx_mandarina EKRPtD--------------------------------------------------------------------- * Danio_rerio EKRPvD--------------------------------------------------------------------- * D_melanogaster EKRPaD--------------------------------------------------------------------- * D_pseudoobscura EKRPaD--------------------------------------------------------------------- * Ixodes_scapularis EKRPqpd-------------------------------------------------------------------- * Pan_troglodytes EKRPvD--------------------------------------------------------------------- * Pongo_pygmaeus EKRPvD--------------------------------------------------------------------- * Schistosoma_japonicum EKiPnl--------------------------------------------------------------------- * Tetraodon_nigroviridis EKRPmD--------------------------------------------------------------------- * Tribolium_castaneum EKRPtD--------------------------------------------------------------------- * X_laevis EKRPvD--------------------------------------------------------------------- * X_tropicalis EKRPvD--------------------------------------------------------------------- ==================================================================================================== * S_CEREVISIAE sEt--sngq----kg------nveesdlygidhdlidefesqgfekdkivevlrrlgvksldpndnntanriiee * Candida_glabrata sae--gsgd------------svdeaqlygidpeivkefesqgfeknkivealrrlgvksldpndnatvnkiiee * Eremothecium_gossypii s------gq----tg------ndeeaqlygidkglvdtlvaqgferekvvqalrrlgiktmdkgdnekaniilee * Kluyveromyces_lactis ssnggDngtnslgkgteenvqeldeadlygidqdlvtqfvnqgfdrqnvievlkrlniksmsmednetankilee ==================================================================================================== Consensus ekrpxdxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 230 240 250 260 270 280 290 300 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xx =========================== * HUMAN -- * Anopheles_gambiae -- * Apis_mellifera -- * Bombyx_mandarina -- * Danio_rerio -- * D_melanogaster -- * D_pseudoobscura -- * Ixodes_scapularis -- * Pan_troglodytes -- * Pongo_pygmaeus -- * Schistosoma_japonicum -- * Tetraodon_nigroviridis -- * Tribolium_castaneum -- * X_laevis -- * X_tropicalis -- =========================== * S_CEREVISIAE ll * Candida_glabrata ll * Eremothecium_gossypii ll * Kluyveromyces_lactis ll =========================== Consensus xx

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