CCAPD: Alignment of eIF2a (eukaryotic Initiation Factor 2a)

10 20 30 40 50 60 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus sxsxcrfyexkfpeidxxvvvdvqqvaemgayvklleydnlegmiilseisrrrlrsirklirvg ================================================================================================= * HUMAN p-----glscRFyQhkfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink * Bombyx_mandarina ------plscRFyQekypeVeDVvmVnvrsiaemgayvhlLEynnIegmIllseLsrrRirsink * Danio_rerio p-----glscRFyQhrfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink * Chicken p-----alscRFyQhkfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink * Mouse p-----glscRFyQhkfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink * Oncorhynchus_mykiss p-----nlscRFyQhrfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink * Pongo_pygmaeus p-----glscRFyQhkfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink * Strongylocentrotus_purpuratus ------piscRFyEqhfpeVeDVvmVkvrsiaemgayvhlLEynkIegmIllseLsrrRirsink * Tetraodon_nigroviridis p-----glscRFyEhrfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink * Tribolium_castaneum ------plscRFyrekypeVeDVvmVnvraiaemgayvhlLEyknIegmIllseLsrrRirsink * X_laevis p-----glncRFyQhkfpeVdDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink * X_tropicalis p-----alscRFyQhkfpeVdDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsink ================================================================================================= * S_CEREVISIAE StShCRFYEnKYPEIDdiVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVG * Aspergillus_flavus SlTnCRFYEeKYPEVDsyVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIG * Aspergillus_fumigatus SlTnCRFYEeKYPEVDsyVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIG * Candida_albicans StTnCRFYEnKYPEVDevVMVNVQEIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIQKLIRVG * Candida_glabrata SiNhCRFYEnKYPDVDdvVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVG * Chaetomium_globosum SlSnCRFYEeKYPEIDsfVMVNVKQIADMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVG * Coccidioides_immitis SlTnCRFYEeKYPEIDsfVMVNVKQIAEMGAYVnLLEYDNIDGMILLSELSRRRIRSIQKLIRVG * Cryptococcus_neoformans ----pRFYEnKYPEVDqlVMVqVQsIeDMGAYVKLLEYDNIEGMILLSELSRRRIRSVQKLIRVG * Debaryomyces_hansenii SsShCRFYEnKYPEVDevVMVNVQEIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIQKLIRVG * Emericella_nidulans SlTnCRFYEeKYPEVDsyVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIG * Eremothecium_gossypii StSnCRFYEnKYPEVDdvVMVNVQQIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIhKLIRVG * Gibberella_zeae SlTnCRFYEeKYPEIDsfVMVNVKQIAEMGAYVKLLEYDDIDGMILLSELSRRRIRSIQKLIRVG * Kluyveromyces_lactis StSnCRFYEnKFPEVDdvVMVNVQQIAEMGAYVRLLEYDNIEGMVLLSELSRRRIRSIQKLIRVG * Magnaporthe_grisea SlTnCRFYEeKYPEIDsfVMVNVKQIADMGAYVKLLEYDgIDGMILLSELSRRRIRSIQKLIRVG * Neurospora_crassa SlSnCRFYEeKYPEIDsfVMVNVKQIADMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVG * Schizosaccharomyces_pombe StTsCRmYEnRFPEVDelVVVNVRQIqEMGAYVKLLEYDNIEGMVLLSELSRRRIRSVQKhIRVG * Ustilago_maydis -----RFYKkElPDVDevVMcqVQQIAEMGAYVKLLEYDgaEGMILLSELSRRRIRSIQKLIRVG * Yarrowia_lipolytica NtTtCRFYanKYPEVDdlVMVNVKEIADMGAYVKLLEYDDIEGMILLSELSRRRIRSIQKhIKVG ================================================================================================= Consensus sxsxcrfyexkfpeidxxvvvdvqqvaemgayvklleydnlegmiilseisrrrlrsirklirvg 70 80 90 100 110 120 130 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus kneixvvlrvdkerxxxxxxxgxxyidlskrrvsxkdiikcekkyxknkilhsvlxxlaexxexx ================================================================================================= * HUMAN lirIgrnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeq * Bombyx_mandarina lirVgktepVvviRvdkekgyidlskrrvsaediyKcteRyaKakavNsILrhVaelLhyetseq * Danio_rerio lirIgrnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeq * Chicken lirIgrnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeq * Mouse lirIgrnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeq * Oncorhynchus_mykiss lirIgrnecVvviRvdkekgyidlskrrvspedaiKcedKftKsktvysILrhVaevLeytkDeq * Pongo_pygmaeus lirIgrneRVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeq * Strongylocentrotus_purpuratus l---------vviRvdkdkgyidlskrrvsaeeikKceeKyaKakavNsILrhVgeiLgyssnsq * Tetraodon_nigroviridis lirIgrnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeyskDeq * Tribolium_castaneum lirVgktepVvviRvdkdkgyidlskrrvsaedveKcteRfaKakavNsILrhVaelLkyesDeq * X_laevis lirIgrnecVvviRvdkdkgyidlskrrvspeealKcedKftKsktvysILrhVaevLdytkDeq * X_tropicalis lirIgrnecVvviRvdkdkgyidlskrrvspeealKcedKftKsktvysILrhVaevLeytkDeq ================================================================================================= * S_CEREVISIAE KNDVaVVLRVDKEK-------G--YIDLSKRRVSsEDIIKCEEKYqKSKtVHSILrycAEkfQip * Aspergillus_flavus RNEVvIVLRVDKEKgnilllvG--YIDLSKRRVSpEDVIKCEERYnKSKaVHSIMrhVAEatQtp * Aspergillus_fumigatus RNEVvIVLRVDKEK-------GkcYIDLSKRRVSpEDVVKCEERYnKSKaVHSIMrhVAEatQtp * Candida_albicans KNEVaVVLRVDKEK-------G--YIDLSKKvVSaEDIVKCDERYnKSKaVHSILrhcAEkfnip * Candida_glabrata KNDVaVVLRVDKEK-------G--YIDLSKRRVSsEDIIKCEEKYqKSKtVHSILrycAEkfQip * Chaetomium_globosum RNEVvVVLRVDKEK-------G--YIDLSKRRVSpEDIVRCEERYnKSKIVHSIMrhVAEktQtp * Coccidioides_immitis RNEVvVVLRVDKEK-------G--YIDLSKRRVSaEDVVKCEERYnKSKsVHSIMrhVAEktrtp * Cryptococcus_neoformans RNEVvVVMRVDpDK-------G--YIDLSKRRVSaEEVVKCEEQYeKgKaVdSIItqVAKkrgvt * Debaryomyces_hansenii KNEVaVVLRVDKEK-------G--YIDLSKRRVSaEDIVKCDERYnKSKaVHSILrhcAEkftis * Emericella_nidulans RNEVvIVLRVDKEK-------G--YIDLSKRRVSpEDVIKCEERYnKSKaVHSILrhVAEatQtp * Eremothecium_gossypii KNEVvVVLRVDKEK-------G--YIDLSKRRVSsEDMIKCEERYqKSKaVHSILrqcAEkfQfp * Gibberella_zeae RNEVvVVLRVDKEK-------G--YIDLSKRRVSpEDIVKCEERYnKSKMVHSVMihLAKatEip * Kluyveromyces_lactis KNEVvVVLRVDKEK-------G--YIDLSKRRVSaEDVIKCEERYqKSKaVHSILrqcAEkyQvs * Magnaporthe_grisea RNEVvVVLRVDKEK-------G--YIDLSKRRVSqEDIVKCEERYnKSKMVHSIMrhVAEktlvp * Neurospora_crassa RNEVvVVLRVDKEK-------G--YIDLSKRRVSpEDIVRCEERYnKSKIVHSIMrhVAEktlvp * Schizosaccharomyces_pombe RNEVvVVLRVDKEK-------G--YIDLSKRRVSpEDVVKCEERFnKSKaVHSIMrhIAEkhnvp * Ustilago_maydis RNEVvVVLRVDKEK-------G--YIDLSKRRVSpEDVIKCEEQFtKSKaVHSIIahVAgklsre * Yarrowia_lipolytica KNEIvVVLRVDKDK-------G--YIDLSKRRVSaEDVeKCEEKYtKSKtVHSILrhVAEkhKys ================================================================================================= Consensus kneixvvlrvdkerxxxxxxxgxxyidlskrrvsxkdiikcekkyxknkilhsvlxxlaexxexx 140 150 160 170 180 190 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus lesLFEkiAWplNKKYgxxxxhAFDAFKlsVSDxPnIfDxLExxxNEExrEeLxxxISRRltpxx ================================================================================================= * HUMAN LESLFQRtAWvfDdKYkrpgygAYDAFKhaVSD-PSIlDsLD--lNEDeREvLinnINRR-ltpq * Bombyx_mandarina sEeLYKKtAWyfeEKYkkka-sAYDfFKqaavD-PSVlDecg--lDEEtKDvLlanIkRK-ltsq * Danio_rerio LESLFQRtAWvfDEKYkkpgygAYDvFKqaVSD-PaIlDgLD--ltEEeRnvLidnINRR-ltpq * Chicken LESLFQRtAWvfDdKYkrpgygAYDAFKhaVSD-PaIlDsLD--ltEEeRrvLidnINRR-ltpq * Mouse LESLFQRtAWvfDdKYkrpgygAYDAFKhaVSD-PSIlDsLD--lNEDeREvLinnINRR-ltpq * Oncorhynchus_mykiss LESLFtRtAWvfDEKYkrpgygAYDvFKqaVSD-PaMlDgLD--ltEEeRavLidnINRR-ltpq * Pongo_pygmaeus LESLFQRtAWvfDdKYkrpgygAYDAFKhaVSD-PSIlDsLD--lNEDeREvLinnINRR-ltpq * Strongylocentrotus_purpuratus LEeLY----------YksvgygAYEAFKtcVNE-PeLlaecn--lDEEthKvLlenIeRK-ltpq * Tetraodon_nigroviridis LErLYQRtAWvfDEKYkrpgygAYDAFKqaVSD-PSIlDgLD--ltEEeRgvLidnINRR-ltpq * Tribolium_castaneum LEeLYQKtAWyfeEKYkknkasAYDfFKqaVSD-PSIlaecQ--lDDrtKEvLlsnIkRK-ltsq * X_laevis LDSLFQRtAWvfDEKYkkpgygAYDAFKnaVSD-PDIlDgLD--lSEDeRrvLidnINRR-ltpq * X_tropicalis LESLYQRtAWvfDEKYkkpgygAYDAFKhaVSD-PDVlDgLD--lNEDeRrvLidnINRR-ltpq ================================================================================================= * S_CEREVISIAE LEeLYKtIAWPLSRKFG----HAYEAFKLSIiD-etVWEgIE-ppSKDvlDELknyISKRLTPqa * Aspergillus_flavus LETLYQnIAWPLNRKYG----HshDAFKISITN-tDVWNdVE-fpSEavKKELtqyISKRLTPhp * Aspergillus_fumigatus LEeLYQKIgWPLNRKYG----HAhDAFKISITN-PDVWqdVE-fpSEavKKELtqyISKKLTPsp * Candida_albicans LErLYEtIgWPLSRKYG----HAYDAFKISITD-PSVFDsVD-vpSKDvlEELklyISRRLTPqa * Candida_glabrata LEdLYKtIAWPLSRKFG----HAYEAFKLSIiD-etVWEgIE-ppSQDilnELktyISKRLTPqa * Chaetomium_globosum IETLYEtIgWPLNKKYG----HAlDAFKLSITN-PDIWtdIK-fptDadaEELksyIgKKLTPqp * Coccidioides_immitis IETLYQQIgWPLNKKYG----HAnDAFKLSITN-PSIWDdVt-fpSQavKDELllhISKRLTPqp * Cryptococcus_neoformans pESLYEKIAWPLHRQYG----HAYEAFKLSISEpeaVFgsLE--lDEEtlaDLrsgIaRRLTPkp * Debaryomyces_hansenii LETLYQsIgWPLSRRYG----HAYDAlKLSITD-PtIFDdIE-apSpDvlEELklyISRRLTPqa * Emericella_nidulans LETLYQQIAWPLNRKYG----HshDAFKISITN-PDVWadVE-fpNEavKKELtqyIgKRLTPhp * Eremothecium_gossypii LEdLYKtIAWPLSRKYG----HAYDAFKLSIvD-etVWEgIE-ppSaEifEELkqyISRRLTPqa * Gibberella_zeae LETLYQaIAWPLNKKFG----HAlDAFKLSITN-PeVWNdIt-fpDEvtaQELktyIgKRLTPqp * Kluyveromyces_lactis LEdLYKayAWPLSRKYG----HAYDAYKMSIvD-PNVWDgIE-siSDEifQELkgqITRRLTPqa * Magnaporthe_grisea IESLYEaIAWPLNRKYG----HAiDAFKLSITN-PeVWEdtt-fsSEavaEELksyISKRLTPqp * Neurospora_crassa IEqLYEtIgWPLNKKYG----HslDAFKLSITN-PDVWNdIQ-fptEavaEELktyISKRLTPqp * Schizosaccharomyces_pombe LETMYttIgWPLyRKYG----HAYDAFKLaISNpdHVFEgLE-ppksgvinDLlaqISRRLTPqp * Ustilago_maydis VEeLYDtIvFPLHEKYG----HAFDAFKLaIlDmdktFEgIQ--mDDDvRKELyanIaRRMTPqp * Yarrowia_lipolytica LEkLYEQVgWPLStKYG----HAYDgFKLSITNpdqVFgdLEdpaSpaimEDLkaqIgRRLTPnp ================================================================================================= Consensus lesLFEkiAWplNKKYgxxxxhAFDAFKlsVSDxPnIfDxLExxxNEExrEeLxxxISRRltpxx 200 210 220 230 240 250 260 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xkiradvevscfxyegidaikkalxxaexxnsxexxvkxkllxaplfvvsstxldexxgixxvxe ================================================================================================= * HUMAN avkiradievacygyegidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVls * Bombyx_mandarina avkiradiecacygyegidavRAalkAglalStvdmpikinLiAPplyVmTTstpEktdglkalQ * Danio_rerio avkiradievacygyegidavKealrAglncStEampikinLiAPpryVmTTttlErteglsVln * Chicken avkiradievacygyegidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVln * Mouse avkiradievacygyegidavKealrAglncStEtmpikinLiAPpryVmTTttlErteglsVln * Oncorhynchus_mykiss avkiradievacygyegidavKdalrAglscStEampikinLiAPpryVmTTttlErteglsVln * Pongo_pygmaeus avkiradievacygyegidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVls * Strongylocentrotus_purpuratus avkiradievacyg----------ltkgldmSsEempikinLiAPpqyVvTTqtlErvegveklK * Tetraodon_nigroviridis avkiradievacygydgidavKdalrAglscStDvmpikinLiAPpryVmTTttlErteglsVln * Tribolium_castaneum avkiradiecacygyegidavKtalksglslStDelpikinLiAPplyVmTTstpEkqdglkIln * X_laevis avkiradievacygyegidavKdalrAglscStEnmpikinLiAPpryVmTTttlErteglsVln * X_tropicalis avkiradievacygyegidavKdalrAglscStEnmpikinLiAPpryVmTTttlErteglsVln ================================================================================================= * S_CEREVISIAE vKIRADVEVSCFsYEGIDAIKdALksAEdmSTeQmqVKvKLVaAPLYVLTTqaLDKqkGIeqLes * Aspergillus_flavus tKVRADIEVTCFgYEGIDAVKaALrtAEeaNTpDsqVKvKLVapPLYVLTSqcLDKaiGIkqLeE * Aspergillus_fumigatus tKVRADIEVTCFgYEGIDAVKnALrtAEanNTpEnqIKvKLVapPLYVLTSqcLDKnlGIklLeE * Candida_albicans inIRADVDVSCFsYEGIDAIKEALkaAEsvSTsQmqVKaKLVaAPLYfITvqaLDKneGVklLeK * Candida_glabrata vKIRADVEVSCFsYEGIDAIKEALksAEdmSTeQmqIKvKLVaAPLYVLTTqaLDKqiGIdlLgK * Chaetomium_globosum tKVRADIEVTCFgYEGIDAIKtALrtAEarNTdEaqVKcRLVspPLYVLTNTcLDKnaGIarLeE * Coccidioides_immitis tKVRADIEVTCFsYEGIDAVKEALrtAEanNTtDnqVKvKLVspPLYVLTShcLDKnlGIktLeD * Cryptococcus_neoformans vKVRADIEVkCFsYaGIDAIKRALtagEavSTpDvpIKvRLVapPLYVMSTTstDKnaaIelMeK * Debaryomyces_hansenii iKIRADVEVSCFsYEGIDAIKKALtaAEeiSTeQmaVKaKLVaAPLYVISvqaLDKnqGIalLeK * Emericella_nidulans tKVRADIEVTCFgYDGIDAVKnALrtAEaeNTpEnqIKvKLVapPLYVLTSqcLDKthGIkmLeE * Eremothecium_gossypii iKIRADVEVSCFsYEGIEAIKEALkaAEatSTeQmqVKvKLVaAPLYVITTqaLDKnqGIeaLnh * Gibberella_zeae tKVRADVEVTCFgYDGIDAIKtALhtAEakNTeEtqVKvRLVspPLYVLNSTcLDKslGItrLqE * Kluyveromyces_lactis vKIRADVEVSCFsYEGIDAIKEALksAEelSTeQmqIKvKLVaAPLYVITTqsLDKdqGVqlLet * Magnaporthe_grisea tKVRADVEVTCFaYDGIDAIKtALrtAEsrNTqDnqVKvKLVspPLYVLTSTcLDKslGIarLeE * Neurospora_crassa tKVRADVEVTCFgYEGIDAIKtALrtAEarNTeEtqVKcRLVspPLYVLTNTcLDKnaGIarLqE * Schizosaccharomyces_pombe iKIRADVEVTCFgYEGINAIKaALkaAEdvHTeEvpIKvKLVapPLYVLlTnaLDKslGLkkLeE * Ustilago_maydis vKIRADVEVTCFgYEGIDAVKKALragEavSTeaipIKiKLVapPLYVLiTnstDKvgGIalMeQ * Yarrowia_lipolytica vKVRADIDITCFaYEGIEAIKKALaagEtlNSelvpVKvKLVaAPLFVLTSTcLDKqkaIdtLgE ================================================================================================= Consensus xkiradvevscfxyegidaikkalxxaexxnsxexxvkxkllxaplfvvsstxldexxgixxvxe 270 280 290 300 310 320 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus aixxvxkxixexxgxvxixmxpkavtxnedaelqalleqreqqdxaEvxgDdexxxxexxxxxxx ================================================================================================= * HUMAN qamaViKekiEekrgVfnvqmepkVvtDtDetelArqmERlEREnAEVdGDDDae--E------- * Bombyx_mandarina daidkiQeniteaGgVfniqmapkVvtatDeaelArqmERaEaEnAEVaGDsaee--D------- * Danio_rerio qamaaiKeriEekrgVfnvqmepkVvtDtDetelqrqlERlEREnAEVdGDDDae--E------- * Chicken qamaViKekiEekrgVfnvqmepkVvtDtDetelAr----------------------------- * Mouse qamaViKekiEekrgVfnvqmepkVvtDtDetelArqlERlEREnAEVdGDDDae--E------- * Oncorhynchus_mykiss qamaaiKeriEekrgVfniqmeakVvtDtDetelArqlERlEREnAEVdGDDEdg--E------- * Pongo_pygmaeus qamaViKekiEekrgVfnvqmepkVvtDtDetelArqmERlEREnAEVdGDDDae--E------- * Strongylocentrotus_purpuratus eaieaiKesilksagVfkv----------EeQelArhlEnlEKanAEVdGDDDge--E------- * Tetraodon_nigroviridis qamaaiKekiEekrgVfniqmepkVvtDtDetelArqlERlEREnAEVdGDDDae--E------- * Tribolium_castaneum daiekiKatiselGgVfnvqmapkVvtatDeaelqrqmERaElEntEVaGDDDde--Edgdegqv * X_laevis qamsViKeriEekrgVfnvqmepkVvtDtDetelArqlERlEKEnAEVdGDDDad--E------- * X_tropicalis qamsViKeriEekrgVfnvqmepkVvtDtDetelArqlERlEKEnAEVdGDDDae--E------- ================================================================================================= * S_CEREVISIAE AIekItEvItKygGvcnItMpPKAVTatEDAELQALLEsKEldN-rsdseDDE--des------- * Aspergillus_flavus AIqrIeakIkEagGgcsVkMaPKAVTeHDDAaLQeLMEKRERENmevsgdEsQ--ses------- * Aspergillus_fumigatus AIerIdseIkKagGgcvVkMaPKAVTeHDDAaLQeLMDKREREN-mEVsGDEs--msE------- * Candida_albicans AIekItEsIeasgGnckVsMpPKAVSaNEDAELErMLQRREaED-k-dssDEE--dda------- * Candida_glabrata AIdkInEvIsKygGvcnItMpPKAVTatEDAELQALLEsKEQdN-rsdse-DE--dns------- * Chaetomium_globosum AIvdVrtsIesagGnLvVkMaPKAVTeSDDAELQALMEKREREN-AEVsGDEs-vses------- * Coccidioides_immitis AIkgItEkIrasgGscvVqMaPKAVTeeDEADLQALMEKKEREN-qEVsGDEs-vses------- * Cryptococcus_neoformans AVevIgEtVrKdkGdItIkMkPKvVSetEDAELKALMEQfEaaN-mDqaGDDE--ssE------- * Debaryomyces_hansenii AIekVsEsIensgGickVtMsPKAVTatEDAELQALLERKEaED-kEssdEEE--ed-------- * Emericella_nidulans AIerIettIkasgGgctVkMaPKAVTeHDDAaLQeLMEKREREN-mEVsGDEs--qsE------- * Eremothecium_gossypii AIskIeEyIaKyqGvcnVtMpPKAVTatEDAELQALLEsKElEN-rsdseEED--sdy------- * Gibberella_zeae AIvdIrasIeaagGhLtVkMePKAVTeSDDAELQALMEKREREN-AEVsGDEs--msD------- * Kluyveromyces_lactis AIakIeEvIlKynGvcnVtMaPKAVTatEDAELQALLEsKElEg-rsdseDED--sdy------- * Magnaporthe_grisea AIvdIrtsIesagGkLiVkMePKAVTeSDDAELQALMEKREREN-AEVsGDEs-vsds------- * Neurospora_crassa AIqdMrtsIeaagGhLvVkMePKAVTeSDDAELQALMEKREREN-AEVsGDEs-vses------- * Schizosaccharomyces_pombe AIgaIeKsItasnGtctVkMkPKAVSetDElELadLMKKfEKEN-AEIsGDEE--ddQ------- * Ustilago_maydis ALekItEsIrangGdVdIkMkPKtVSevEDqELEqLMahfEKQN-AEVeGDED--seg------- * Yarrowia_lipolytica AIekIrEsIeasgGsLtVkMePKAVTetDDAELakLMEKtEQQN-klVdGDDDdadeE------- ================================================================================================= Consensus aixxvxkxixexxgxvxixmxpkavtxnedaelqalleqreqqdxaEvxgDdexxxxexxxxxxx 330 340 350 360 370 380 390 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= * HUMAN -mEakaed--------------------------------------------------------- * Bombyx_mandarina -eDqgmgdanmdgepqqngasdeeddn-------------------------------------- * Danio_rerio -mEakted--------------------------------------------------------- * Chicken ----------------------------------------------------------------- * Mouse -mEakaed--------------------------------------------------------- * Oncorhynchus_mykiss -mEakaed--------------------------------------------------------- * Pongo_pygmaeus -mEakaed--------------------------------------------------------- * Strongylocentrotus_purpuratus -i-gneed--------------------------------------------------------- * Tetraodon_nigroviridis -mEakaed--------------------------------------------------------- * Tribolium_castaneum ynEndnesepeed---------------------------------------------------- * X_laevis -mEakted--------------------------------------------------------- * X_tropicalis -mEakted--------------------------------------------------------- ================================================================================================= * S_CEREVISIAE -dDe------------------------------------------------------------- * Aspergillus_flavus -dDg-vpe--------------------------------------------------------- * Aspergillus_fumigatus -sDe------------------------------------------------------------- * Candida_albicans ----------------------------------------------------------------- * Candida_glabrata -dye------------------------------------------------------------- * Chaetomium_globosum -dDn------------------------------------------------------------- * Coccidioides_immitis -dDa---------------mve------------------------------------------- * Cryptococcus_neoformans -eDe------------------------------------------------------------- * Debaryomyces_hansenii ----------------------------------------------------------------- * Emericella_nidulans -sDe------------------------------------------------------------- * Eremothecium_gossypii -e--------------------------------------------------------------- * Gibberella_zeae -sDenipetm------------------------------------------------------- * Kluyveromyces_lactis -e--------------------------------------------------------------- * Magnaporthe_grisea -dDn-mpetmgscggglaaiieaegdigfqrksvedevdlditvafagkkyisrktiniaavtei * Neurospora_crassa -dDn-ipetv------------------------------------------------------- * Schizosaccharomyces_pombe -sgs------------------------------------------------------------- * Ustilago_maydis -dD-------------------------------------------------------------- * Yarrowia_lipolytica -agd------------------------fe----------------------------------- ================================================================================================= Consensus xxExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 400 410 420 430 440 450 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= * HUMAN ----------------------------------------------------------------- * Bombyx_mandarina ----------------------------------------------------------------- * Danio_rerio ----------------------------------------------------------------- * Chicken ----------------------------------------------------------------- * Mouse ----------------------------------------------------------------- * Oncorhynchus_mykiss ----------------------------------------------------------------- * Pongo_pygmaeus ----------------------------------------------------------------- * Strongylocentrotus_purpuratus ----------------------------------------------------------------- * Tetraodon_nigroviridis ----------------------------------------------------------------- * Tribolium_castaneum ----------------------------------------------------------------- * X_laevis ----------------------------------------------------------------- * X_tropicalis ----------------------------------------------------------------- ================================================================================================= * S_CEREVISIAE ----------------------------------------------------------------- * Aspergillus_flavus ----------------------------------------------------------------- * Aspergillus_fumigatus ----------------------------------------------------------------- * Candida_albicans ----------------------------------------------------------------- * Candida_glabrata ----------------------------------------------------------------- * Chaetomium_globosum ----------------------------------------------------------ipaav-- * Coccidioides_immitis ----------------------------------------------------------------- * Cryptococcus_neoformans ----------------------------------------------------------------- * Debaryomyces_hansenii ----------------------------------------------------------------- * Emericella_nidulans ----------------------------------------------------------------- * Eremothecium_gossypii ----------------------------------------------------------------- * Gibberella_zeae ----------------------------------------------------------------- * Kluyveromyces_lactis ----------------------------------------------------------------- * Magnaporthe_grisea vgdiyvsdclsshvnplkptlmapgfawarararawaarpgftfaqnfstsllryltwlpvaivf * Neurospora_crassa ----------------------------------------------------------------- * Schizosaccharomyces_pombe ----------------------------------------------------------------- * Ustilago_maydis ----------------------------------------------------------------- * Yarrowia_lipolytica ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 460 470 480 490 500 510 520 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= * HUMAN ----------------------------------------------------------------- * Bombyx_mandarina ----------------------------------------------------------------- * Danio_rerio ----------------------------------------------------------------- * Chicken ----------------------------------------------------------------- * Mouse ----------------------------------------------------------------- * Oncorhynchus_mykiss ----------------------------------------------------------------- * Pongo_pygmaeus ----------------------------------------------------------------- * Strongylocentrotus_purpuratus ----------------------------------------------------------------- * Tetraodon_nigroviridis ----------------------------------------------------------------- * Tribolium_castaneum ----------------------------------------------------------------- * X_laevis ----------------------------------------------------------------- * X_tropicalis ----------------------------------------------------------------- ================================================================================================= * S_CEREVISIAE ----------------------------------------------------------------- * Aspergillus_flavus ----------------------------------------------------------------- * Aspergillus_fumigatus ----------------------------------------------------------------- * Candida_albicans ----------------------------------------------------------------- * Candida_glabrata ----------------------------------------------------------------- * Chaetomium_globosum ----------------------------------------------------------------- * Coccidioides_immitis ----------------------------------------------------------------- * Cryptococcus_neoformans ----------------------------------------------------------------- * Debaryomyces_hansenii ----------------------------------------------------------------- * Emericella_nidulans ----------------------------------------------------------------- * Eremothecium_gossypii ----------------------------------------------------------------- * Gibberella_zeae ----------------------------------------------------------------- * Kluyveromyces_lactis ----------------------------------------------------------------- * Magnaporthe_grisea tsnvaepykiagpsmypffnkernetrlqdwcmnwklnaqddlrrgmivvfwnplkpesrsvkri * Neurospora_crassa ----------------------------------------------------------------- * Schizosaccharomyces_pombe ----------------------------------------------------------------- * Ustilago_maydis ----------------------------------------------------------------- * Yarrowia_lipolytica ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 530 540 550 560 570 580 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= * HUMAN ----------------------------------------------------------------- * Bombyx_mandarina ----------------------------------------------------------------- * Danio_rerio ----------------------------------------------------------------- * Chicken ----------------------------------------------------------------- * Mouse ----------------------------------------------------------------- * Oncorhynchus_mykiss ----------------------------------------------------------------- * Pongo_pygmaeus ----------------------------------------------------------------- * Strongylocentrotus_purpuratus ----------------------------------------------------------------- * Tetraodon_nigroviridis ----------------------------------------------------------------- * Tribolium_castaneum ----------------------------------------------------------------- * X_laevis ----------------------------------------------------------------- * X_tropicalis ----------------------------------------------------------------- ================================================================================================= * S_CEREVISIAE ----------------------------------------------------------------- * Aspergillus_flavus ----------------------------------------------------------------- * Aspergillus_fumigatus ----------------------------------------------------------------- * Candida_albicans ----------------------------------------------------------------- * Candida_glabrata ----------------------------------------------------------------- * Chaetomium_globosum ----------------------------------------------------------------- * Coccidioides_immitis ----------------------------------------------------------------- * Cryptococcus_neoformans ----------------------------------------------------------------- * Debaryomyces_hansenii ----------------------------------------------------------------- * Emericella_nidulans ----------------------------------------------------------------- * Eremothecium_gossypii ----------------------------------------------------------------- * Gibberella_zeae ----------------------------------------------------------------- * Kluyveromyces_lactis ----------------------------------------------------------------- * Magnaporthe_grisea vglegdivrnrdsdvwvrvpvghiwvegdagsrdsrdsnyygpisarliigrltrilfpfhrsgs * Neurospora_crassa ----------------------------------------------------------------- * Schizosaccharomyces_pombe ----------------------------------------------------------------- * Ustilago_maydis ----------------------------------------------------------------- * Yarrowia_lipolytica ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 590 600 610 620 630 640 650 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxx ==================================================== * HUMAN -------------------- * Bombyx_mandarina -------------------- * Danio_rerio -------------------- * Chicken -------------------- * Mouse -------------------- * Oncorhynchus_mykiss -------------------- * Pongo_pygmaeus -------------------- * Strongylocentrotus_purpuratus -------------------- * Tetraodon_nigroviridis -------------------- * Tribolium_castaneum -------------------- * X_laevis -------------------- * X_tropicalis -------------------- ==================================================== * S_CEREVISIAE -------------------- * Aspergillus_flavus -------------------- * Aspergillus_fumigatus -----------------gvp * Candida_albicans -------------------- * Candida_glabrata -------------------- * Chaetomium_globosum -------------------- * Coccidioides_immitis -------------------- * Cryptococcus_neoformans -------------------- * Debaryomyces_hansenii -------------------- * Emericella_nidulans -----------------gvp * Eremothecium_gossypii -------------------- * Gibberella_zeae -------------------- * Kluyveromyces_lactis -------------------- * Magnaporthe_grisea inwrdhpenprviktqdmvp * Neurospora_crassa -------------------- * Schizosaccharomyces_pombe -------e------------ * Ustilago_maydis -------------------- * Yarrowia_lipolytica -------------------- ==================================================== Consensus xxxxxxxxxxxxxxxxxxxx

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