CCAPD: Alignment of eTF2a (eukaryotic Termination Factor 2a)

10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxaxsanxnxxxxxxxxxxxxxxxxxxxxvxxxxxxxxxxxxxxxprvyksivzdvvnevreiflndgide ==================================================================================================== * S_CEREVISIAE -----------------------------snaea---------------sRVYEiIVZsVVNEVREdFeNaGIDE * S_cerevisiae-TOA1 -----------------------------snaea---------------sRVYEiIVEsVVNEVREdFeNaGIDE ==================================================================================================== * HUMAN ------AnSANtN-------------------tV---------------PKLYRSVIEDVINDVRDIFLDDGVDE * Canis_lupus rycwafkeNdNrN-------------------tasyinselqvfifplkPKLYRSVIEDVINDVRDIFLDDGVDE * Danio_rerio ------AsSANsN-------------------qV---------------PKLYRSVMEDVIaEVRELFLDEGVDE * Chicken --------------------------------------------------------------------------- * Mouse ------AnSANtN-------------------tV---------------PKLYRSVIEDVINDVRDIFLDDGVDE * Pan_troglodytes pivsstsrStktNkkslqwskcprfrleiylllp---------------PKLYRSVIEDVINDVRDIFLDDGVDE * Pongo_pygmaeus ------AnSANtN-------------------tV---------------PKLYRSVIEDVINDVRDIFLDDGVDE * Rat ------AnSANtN-------------------tV---------------PKLYRSVIEDVINDVRDIFLDDGVDE * Tetraodon_nigroviridis -------------------------------------------------PKVYKSVIDDVINEVRELFLDEGVDE * X_laevis ---as-AaSANaN-------------------pV---------------PKLYRSVIgDVINDVREIFLDEGVgE * X_tropicalis ------AaSANaN-------------------pV---------------PKLYRSVIEDVINDVRELFLDEGVDE ==================================================================================================== Consensus xxxxxxaxsanxnxxxxxxxxxxxxxxxxxxxxvxxxxxxxxxxxxxxxprvyksivzdvvnevreiflndgide 80 90 100 110 120 130 140 150 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus qvlmDLKtIxxxxxxxxxxxxxxWQnxxxxxkLmexxxtravdgxxxxxxxxxfhsexeqqlllqvxqqqxxxxx ==================================================================================================== * S_CEREVISIAE QtLqDLKnI--------------WQk-----KLtEtkvTtfswdnqfnegningvqndlnfnLatpgvnssefni * S_cerevisiae-TOA1 QtLqDLKnI--------------WQk-----KLtEtkvTtfswdnqfnegningvqndlnfnLatpgvnssefni ==================================================================================================== * HUMAN QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh---- * Canis_lupus QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh---- * Danio_rerio QVLMELKTL--------------WES-----KLMQ---SKAVDG---------FHTE-EQQVL------------ * Chicken ----ELKTL--------------WEN-----KLMQ---SKAVDG---------FHSE-EQQLLLQVqQQQq---- * Mouse QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh---- * Pan_troglodytes QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh---- * Pongo_pygmaeus QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh---- * Rat QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh---- * Tetraodon_nigroviridis QVLLELKTVhnstvsfsvnihytWENlhrhtpLfsqegSKpLNkhfpvcsnflFyvKysppfLfQL-wEnkllqs * X_laevis QVLMELKTL--------------WES-----KLMQ---SKAVDG---------FHTE-EQQLLLQa-QQQq---- * X_tropicalis QVLMELKTL--------------WES-----KLMQ---SKAVDG---------FHSE-EQQLLLQa-QQQq---- ==================================================================================================== Consensus qvlmDLKtIxxxxxxxxxxxxxxWQnxxxxxkLmexxxtravdgxxxxxxxxxfhsexeqqlllqvxqqqxxxxx 160 170 180 190 200 210 220 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxqpqqqqhnhnnnxhqqxepqqtvxqqxqtqqvlipasqqaxapxxqvvvpeskiiqhmsasxmxnaa ==================================================================================================== * S_CEREVISIAE keentgneglilpniNsNNNiphsgEtnintntveaTnnsgatlNtntsgntnadVtsQpKIevkpeieltiNnA * S_cerevisiae-TOA1 keentgneglilpniNsNNNiphsgEtnintntveaTnnsgatlNtntsgntnadVtsQpKIevkpeieltiNnA ==================================================================================================== * HUMAN --------QPQQQQHHHHHH-HQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLIQHMNASnM-SAA * Canis_lupus --------QPQQQQHHHHHH-HQQtQPQQTVpQQaQTQQVLIPASQQAaAP--QVIVPDSKLIQHMNASnM-SAA * Danio_rerio -----------------Haq-qQQaQaQQT-qQQtQpQQVLLPpaQttpqq--QVIVqDaKIMQHMSATgM-SAA * Chicken --------QqQQQQHHHHHH-HtQpQPQQTVqQQtQpQQVLIPASQQApqq--QVIVPDSKLIpHMNASgM-SAA * Mouse --------QPQQQQHHHHHHqHQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLLQHMNASsItSAA * Pan_troglodytes --------QPQQQQHHHHHH-HQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLIQHMNASnM-SAA * Pongo_pygmaeus --------QPQQQQHHHHHH-HQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLIQHMNASnM-SAA * Rat --------QPQQQQHHHHHH-HQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLIQHMNASsItSAA * Tetraodon_nigroviridis kavegfytEeQtalqaaqqq-qhQvQPvQqVaQptQaQQVILPpqpQqqAPqqQVIVqDSKILQHMSATgM-SAA * X_laevis --------QqQQQhsqHHrv---QqhPQQqqaashQTQQVLIPAThQAqqq--QVLVqESKMIhHMTpqgM-SA- * X_tropicalis --------hPQ-----HHHv-sQhpQqQQaashQtQTQQVLIPAThQApqq--QVLVqDSKLIQHMTtqgM-SAA ==================================================================================================== Consensus xxxxxxxxqpqqqqhnhnnnxhqqxepqqtvxqqxqtqqvlipasqqaxapxxqvvvpeskiiqhmsasxmxnaa 230 240 250 260 270 280 290 300 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus ataatlaipagvtpvqqiltnsgqllqvvraangaqyilxqpkesvvlqqqvipqmqpggvqapviqqvlaplpg ==================================================================================================== * S_CEREVISIAE nittvenIddesekkddeekeedvektrkekeqieQvkLqakKEkrsalldtdevgselddsdddylisegeedG * S_cerevisiae-TOA1 nittvenIddesekkddeekeedvektrkekeqieQvkLqakKEkrsalldtdevgselddsdddylisegeedG ==================================================================================================== * HUMAN ATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG * Canis_lupus ATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG * Danio_rerio ATAATLALPtGVaPfQQLITpqGQILQVVRAANGAQYII-QPQQqMLLQQQVLPQMQPGGVQAPVIQQVLtPLqG * Chicken ATvATLALPAGVTPVQQILTNSGQILQVVRtANGAQYII-QPQQpVVLQQQVIPQMQPGGVQAPVIQQVLAPIPG * Mouse ATAATLALPAGVTPVQQLLTNSGQLLQVVRAANGAQYIL-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG * Pan_troglodytes ATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG * Pongo_pygmaeus ATAATLALPAGVTPVQQILTNSGQLLQVVRvANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG * Rat ATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG * Tetraodon_nigroviridis ATAATLALPAGVTPyQQLLTSqGQLLQVVRAANGtQYLIqQPQQqILLQQ----QMQPaGVQAPVIQQVLtPLPG * X_laevis --AtTLALPAGVTPVQQLITNSGQLLQVVRAANGAQYLI-QPQQSMVLQQQVIPQMQqGGVQAPVIQQVLtPMPG * X_tropicalis ATAATLALPAGVTPVQQLITNSGQLLQVVRAANGAQYLI-QPQQSMVLQQQVIPQMQPGGVQAPVIQQVLAPIPG ==================================================================================================== Consensus ataatlaipagvtpvqqiltnsgqllqvvraangaqyilxqpkesvvlqqqvipqmqpggvqapviqqvlaplpg 310 320 330 340 350 360 370 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus gisxqtgviiqpqqilxftgnkxxxxtqvipttvaaxxxxpxxpaqaqixxxaxgqqqpqxqpaqxqaplvlqvd ==================================================================================================== * S_CEREVISIAE pd------------------------------------------------------------------------- * S_cerevisiae-TOA1 pd------------------------------------------------------------------------- ==================================================================================================== * HUMAN GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--tAtGQQQPQaQPAQtQAPLVLQVD * Canis_lupus GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--tAtGQQQPQtQPAQpQAPLVLQVD * Danio_rerio GLpqQTGVIIQPQQIV-lTGNKvpqnTQVMqaaamAvqsgP-gdAQvQtqpqAqqQQQqQqQqAsqQpPMMLQVD * Chicken GIpqQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--pAaGQQQPQqQqAQpQAPLVLQVD * Mouse GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-aPAQApM--pAaGQQQPQaQPAQqQAPLVLQVD * Pan_troglodytes GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--tttGQQQPQaQPAQtQAPLVLQVD * Pongo_pygmaeus GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--tAtGhQQPQaQPAQtQAPLVLQVD * Rat GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--pAaGQQQPQaQPAQqQAPLVLQVD * Tetraodon_nigroviridis aLpqQTGVIIQPQQIVlaSGNK----vQg-nTqVgt----PlcPsyApp--rAasvpKaQpQPqvqQpPLMLQVD * X_laevis GLSqQTGVIIQPQQIL-FTGNK----TQVIPnTMsA----PqaPiQgQL--tvtsQQQqQ-g--QqQAPLVLQVD * X_tropicalis GLSqQTGVIIQPQQIL-FTGNK----TQVIPTTMsA----PqaPtQgQL--tvtsQQQqQgQ----QqqVVLQVD ==================================================================================================== Consensus gisxqtgviiqpqqilxftgnkxxxxtqvipttvaaxxxxpxxpaqaqixxxaxgqqqpqxqpaqxqaplvlqvd 380 390 400 410 420 430 440 450 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus gxgdtsseededeeedydddeeedkekdgxedgqveeeplnseddvsdeegqelfdtENLMLCqYDKVhRTKnRW ==================================================================================================== * S_CEREVISIAE ---------------------------------------------------------ENLMLClYDKVtRTKaRW * S_cerevisiae-TOA1 ---------------------------------------------------------ENLMLClYDKVtRTKaRW ==================================================================================================== * HUMAN GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW * Canis_lupus GtGDTSSEEDEDEEEDYDDEEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW * Danio_rerio GaGDTSSEEDEEEEDEYDEDEDEDKEKDGgEDGQVEEEPLNSgDDVSDEEdQELFDTENVVVCQYDKIHRSKNKW * Chicken GaGDTSSEEEEDEEEDYDDDEEEDKEKDGgEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW * Mouse GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW * Pan_troglodytes GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW * Pongo_pygmaeus GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW * Rat GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW * Tetraodon_nigroviridis GaGETSSEEEEDEEEEYDEDEDEEKEKEagEDwQVEEEPLNSgDDVSDEEdQELFDTENVVVCQYDKIHRSKNKW * X_laevis GaGDTSSEEDEDEDEDYDDEEEEDKEKDG-EDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW * X_tropicalis GaGDTSSEEDEDEDEDYDDEEEEDKEKDG-EDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW ==================================================================================================== Consensus gxgdtsseededeeedydddeeedkekdgxedgqveeeplnseddvsdeegqelfdtENLMLCqYDKVhRTKnRW 460 470 480 490 500 510 520 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus KfhLKDGVVnINgrDYiFsKAigEAEWx ===================================================== * S_CEREVISIAE KcsLKDGVVtINrnDYtFqKAqvEAEWv * S_cerevisiae-TOA1 KcsLKDGVVtINrnDYtFqKAqvEAEWv ===================================================== * HUMAN KFHLKDGIMNLNGRDYIFSKAIGDAEW- * Canis_lupus KFHLKDGIMNLNGRDYIFSKAIGDAEW- * Danio_rerio KFHLKDGIMNLNGRDFVFSKAIGDAEW- * Chicken KFHLKDGIMNLNGRDYVFSKAIGDAEW- * Mouse KFHLKDGIMNLNGRDYIFSKAIGDAEW- * Pan_troglodytes KFHLKDGIMNLNGRDYIFSKAIGDAEW- * Pongo_pygmaeus KFHLKDGIMNLNGRDYIFSKAIGDAEW- * Rat KFHLKDGIMNLNGRDYIFSKAIGDAEW- * Tetraodon_nigroviridis KFHLKDGIMNLNGKDYVFSKAIGDAEW- * X_laevis KFHLKDGIMNLNGRDFVFSKAIGDAEW- * X_tropicalis KFHLKDGIMNLNGRDFVFSKAIGDAEW- ===================================================== Consensus KfhLKDGVVnINgrDYiFsKAigEAEWx

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