10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xppFtLxYFpVRGRcEaLRMLLADQgqsWKEEvIxxxxxsiesWxexgxxlkxscLYGQLPkfQDGDLtLyQSnA =================================================================================================== * ONCHOCERCA_VOLVULUS --sYkLtYFsIRGlaEpIRLfLvDQdikFiDDrI-----akDdF---s-sIKsqfqFGQLPclyDGDqqIvQSgA * C_briggsae --alkLsYFdIRGlaEpVRLLLvDKqvaFEDhrI-----arDqW---a-eIKpkmIFGQVPcllsGDeeLvQSgA * C_elegans --tlkLtYFdIhGlaEpIRLLLADKqvaYEDhrV-----TyEqW---a-dIKpkmIFGQVPcllsGDeeIvQSgA * Onchocerca --sYkLtYFsIRGlaEpIRLfLvDQdikFiDDrI-----akDdF---s-sIKsqfqFGQLPclyDGDqqIvQSgA =================================================================================================== * PIG -PPYTItYFPVRGRCEAMRMLLADQdQSWKEEVV-----TMETW---p-pLKpSCLFrQLPKFQDGDLTLYQSNA * MOUSE -PPYTIvYFPVRGRCEAMRMLLADQGQSWKEEVV-----TIDTWmQ-G-lLKpTCLYGQLPKFEDGDLTLYQSNA * HUMAN -PPYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqZ-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * 1EOGA_Human --PYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * 1EOHA_Human -PPYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * 1KBNA_Human -PPYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * 1PGTA_Human -PPYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * 22GSA_Human --PYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqE-G-sLKaSCLFGQLPKFQDGDLTLYQSNt * 4GSSA_Human --PYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * Bovine -PPYTIvYFPVQGRCEAMRMLLADQGQSWKEEVV-----aMQSWlQ-G-pLKaSCLYGQLPKFQDGDLTLYQSNA * Canis_lupus mPPYTItYFPVRGRCEAMRMLLADQGQSWKEEVV-----TMETWmK-G-sLKaSCLYGQLPKFQDGDLTLYQSNA * Capra_hircus -asYTIvYFPVQGRCEAMRMLLADQdQSWKEEVV-----aMQSWlQ-G-pLKaSCLYGQLPKFQDGDLTLYQSNA * Cricetulus_griseus -PPYTIvYFPVRGRCEAMRILLADQGQSWKEEVV-----TVETWrK-G-sLKsTCLYGQLPKFEDGDLTLYQSNA * Macaca_mulatta -PPYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TMETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * Mesocricetus_auratus -PPYTIvYFPVRGRCEAMRLLLADQGQSWKEEVV-----TgDSWvK-G-sLKsTCLYGQLPKFEDGDLiLYQSNA * Pongo_pygmaeus -PPYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----SMETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * Rat -PPYTIvYFPVRGRCEAtRMLLADQGQSWKEEVV-----TIDvWlQ-G-sLKsTCLYGQLPKFEDGDLTLYQSNA * Mouse-GSTP2 -PPYTIvYFPspGRCEAMRMLLADQGQSWKEEVV-----TIDTWmQ-G-lLKpTCLYGQLPKFEDGDLTLYQSNA * Human-GSTP1 -PPYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt * Human-GSTP1_VAR -PPYTVvYFPVRGRCaALRMLLADQGQSWKEEVV-----TVETWqE-G-sLKaSCLYGQLPKFQDGDLTLYQSNt =================================================================================================== PLASMODIUM_FALCIPARUM gdnivLyYFdaRGKaElIRLIfAylGieYtDKrfgvngdafveFkn--fkkEkdtpFeQVPilQiGDLiLaQSqA Plasmodium_berghei nffFfffFFfsRGKaElIRLIfAylqvkYtDirfgvngdafaeFnn--fkkEkeipFnQVPilEiGgLiLaQSqA Plasmodium_vivax aeeivLyYFdaRGKaElIRLIfAylGiqYtDKrfgengdafieFknf-kkeKeTpfnqvpilemDniIfaqsqai =================================================================================================== Consensus xppFtLxYFpVRGRcEaLRMLLADQgqsWKEEvIxxxxxsiesWxexgxxlkxscLYGQLPkfQDGDLtLyQSnA 80 90 100 110 120 130 140 150 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus ILRHLGRslGLyGKNQQEaalVDMInDGVQDLrcKYxSLIYtnfexxGKDeFVKaxxLPgxLkpFEtLLsQNqgg =================================================================================================== * ONCHOCERCA_VOLVULUS ILRHLaRkynLnGENEmEttyIDMfcEGVRDLhvKYtrMIYmaYE-teKDpYIKsi-LPGeLakFEkLLatrgnG * C_briggsae ILRHLGRvhGLnGnNEtEttfIDMfyEGIRDLhnKYaqMIYgNYE-nGKDaYIKdt-LPGeLarlEkLfrtyKnG * C_elegans IIRHLaRlnGLnGsNEtEttfIDMfyEGLRDLhtKYtTMIYrNYE-dGKapYIKdv-LPGeLarlEkLfhtyKnG * Onchocerca ILRHLaRkynLnGENEmEttyIDMfcEGVRDLhvKYtrMIYmaYE-teKDpYIKsi-LPGeLakFEkLLatrgnG =================================================================================================== * PIG ILRHLGRSfGLYGKDQKEAALVDMVNDGVEDLRCKYaTLIYTNYE-aGKEKYVKe--LPehLKPFETLLSQNQGG * MOUSE ILRHLGRSLGLYGKNQREAAqMDMVNDGVEDLRgKYvTLIYTNYE-nGKNDYVKA--LPGhLKPFETLLSQNQGG * HUMAN ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYiSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * 1EOGA_Human ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYiSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * 1EOHA_Human ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYiSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * 1KBNA_Human ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYiSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * 1PGTA_Human ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYvSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * 22GSA_Human ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYiSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * 4GSSA_Human ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYiSLIFTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * Bovine ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYvSLIYTNYE-aGKEDYVKA--LPqhLKPFETLLSQNKGG * Canis_lupus ILRHLGRSLGLYGKDQQEAALLDVVNDGVEDLRCKYalLIYTNYE-aGKEEYVKA--LPGyLKPFETLLSQNEGG * Capra_hircus ILRHLGRTLGLYGKDQREAALVDMVNDGVEDLRCKYvSLIYTNYQ-aGKEDYVKA--LPqhLKPFETLLSQNKGG * Cricetulus_griseus ILRHLGRSLGLYGKDQREAALVDMVNDGVEDLRCKYiTLIYTkYE-eGKDDYVKA--LPGhLKPFETLLSQNQGG * Macaca_mulatta fLRHLGRTLGLYGKDQREAALVDMVNDGVEDLRCKYlSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * Mesocricetus_auratus ILRHLGRSLGLYGKDQKEAALVDMaNDGVEDLRCKYvTLIYTkYE-eGKDDYVKA--LPGhLKPFETLLSQNQGG * Pongo_pygmaeus ILRHLGRTLGLYGKDQREAALVDMVNDGVEDLRCKYlSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * Rat ILRHLGRSLGLYGKDQKEAALVDMVNDGVEDLRCKYgTLIYTNYE-nGKDDYVKA--LPGhLKPFETLLSQNQGG * Mouse-GSTP2 ILRHLGRSLGLYGKNQREAAqVDMVNDGVEDLRgKYgTMIYrNYE-nGKNDYVKA--LPGhLKPFETLLSQNQGG * Human-GSTP1 ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYiSLIYTNYE-aGKDDYVKA--LPGqLKPFETLLSQNQGG * Human-GSTP1_VAR ILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYvSLIYTNYE-vGKDDYVKA--LPGqLKPFETLLSQNQGG =================================================================================================== PLASMODIUM_FALCIPARUM IVRyLsKkynIcGESElnefyaDMIfcGVQDIhyKFnN---TNlfkqnEttFLn-edLPkwsgyFEkLLkKNhtn Plasmodium_berghei IVRyLsKkynIsGngElnefyaDMIfcGVQDIhyKFnN---TNlfkqnEttFLn-eeLPkwsgyFEkLLqKNntn Plasmodium_vivax VrylskKykisgnselnEfyadmIfcgvqdihykfnnT---nlFKqnettfln-eelpkwsgyfeniLkknNcn- =================================================================================================== Consensus ILRHLGRslGLyGKNQQEaalVDMInDGVQDLrcKYxSLIYtnfexxGKDeFVKaxxLPgxLkpFEtLLsQNqgg 160 170 180 190 200 210 220 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxKxFIVGNQISFADYnLlDLLxIHEVLaPxCLDsFPLLsAYVaRLSxRPKLKAFLsSpehvnxpinGNGKQ ================================================================================================== * ONCHOCERCA_VOLVULUS ----RnlILGDKISYADYaLfEeLdVHQILdPhCLDkFPLLkvFhqRMkdRPKLKeYcekrDaakvPVNGNGKQ * C_briggsae ----EhYVaGDKeSYADYvLfEeLdIHlILsPtaLDatPVLkkFheRfaeRPnIKAYLNkraaINpPVNGNGKQ * C_elegans ----EhYVIGDKeSYADYvLfEeLdIHlILtPnaLDgvPaLkkFheRfaeRPnIKAYLNkraaINpPVNGNGKQ * Onchocerca ----RnlILGDKISYADYaLfEeLdVHQILdPhCLDkFPLLkAFhqRMkdRPKLKeYcekrDaakvPVNGNGKQ ================================================================================================== * PIG ----QaFVVGSQISFADYNLLDLLrIHQVLnPsCLDaFPLLSAYVARLSaRPKIKAFLaSPEHVNrPINGNGKQ * MOUSE ----KaFIVGDQISFADYNLLDLLlIHQVLAPgCLDNFPLLSAYVARLSaRPKIKAFLSSPEHVNrPINGNGKQ * HUMAN ----KtFIVGDQISFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ * 1EOGA_Human ----KtFIVGDQIaFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ * 1EOHA_Human ----KtFIVGDQISFAaYNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ * 1KBNA_Human ----KtFIVGDQaSFADaNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ * 1PGTA_Human ----KtFIVGDQISFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ * 22GSA_Human ----KtFIVGDQISFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ * 4GSSA_Human ----KtFIVGDQISFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ * Bovine ----QaFIVGDQISFADYNLLDLLrIHQVLAPsCLDSFPLLSAYVARLNsRPKLKAFLaSPEHMNrPINGNGKQ * Canis_lupus ----QaFIVGNQISFADYNLLDLLlIHQVLAPsCLDSFPLLSAYVARLSaRPKLKAFLSSPEHVNrPINGNGKQ * Capra_hircus ----QaFIVGDQISFADYNLLDLLrIHQVLAPsCLDSFPLLSAYVARLNsRPKLKAFLaSPEHVNrPINGNGKQ * Cricetulus_griseus ----KaFIVGDQISFvDYNLLDLLlIHQVLAPgCLDNFPLLSAYVARLSaRPKIKAFLSSPDHVNrPINGNGKQ * Macaca_mulatta ----KtFIVGDQISFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVARLSaRPKLKAFLaSPEHVNlPINGNGKQ * Mesocricetus_auratus ----KaFIVGDQISFADYNLLDLLlIHQVLAPgCLDNFPLLSAYVARLSaRPKIKAFLSSPDHVNrPINGNGKQ * Pongo_pygmaeus ----KtFIVGDQISFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVARLSaRPKLKAFLaSPEHVNlPINGNGKQ * Rat ----KaFIVGNQISFADYNLLDLLlVHQVLAPgCLDNFPLLSAYVARLSaRPKIKAFLSSPDHLNrPINGNGKQ * Mouse-GSTP2 ----KaFIVGDQISFADYNLLDLLlIHQVLAPgCLDNFPLLSAYVARLSaRPKIKAFLSSPEHVNrPINGNGKQ * Human-GSTP1 ----KtFIVGDQISFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ * Human-GSTP1_VAR ----KtFIVGDQISFADYNLLDLLlIHEVLAPgCLDaFPLLSAYVgRLSaRPKLKAFLaSPEyVNlPINGNGKQ ================================================================================================== PLASMODIUM_FALCIPARUM nnndKyYfVGNnLTYADlaVfNLyddiEtkyPssLkNFPLLkAhnefISnlPnIKnYITNrKesvy-------- Plasmodium_berghei ------YfVGDtITYADlaVfNLyddiEskyPnCLkNFPLLkAhIelISniPnIKhYIaNrKesvy-------- Plasmodium_vivax ------YfVGDdLTYADlaVfNLyddiEtkyPnsLkNFPLLkAhnefISnlPnIKnYISNrKesvy-------- ================================================================================================== Consensus xxxxKxFIVGNQISFADYnLlDLLxIHEVLaPxCLDsFPLLsAYVaRLSxRPKLKAFLsSpehvnxpinGNGKQ
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