10 20 30 40 50 60 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= A PYRFU ----------------------------------------------------------------- A Pyrococcus_abyssi ----------------------------------------------------------------- ================================================================================================= * HUMAN ----------------------------------------------------------------- * S_CEREVISIAE ----------------------------------------------------------------- P ARABIDOPSIS_THALIANA ----------------------------------------------------------------- * 1JFIC_Human ----------------------------------------------------------------- * 1TBPA_S_cerevisiae ----------------------------------------------------------------- * Anopheles_gambiae ----------------------------------------------------------------- * Apis_mellifera ---------dqmlps------pgfsi----psigtpl-hqpeedqqilpnal------------- * Aspergillus_flavus ----------------------------------------------------------------- * Aspergillus_fumigatus ---esltthpstaqqaraftspaslsf-p--ggagdltppssekegnit-------igaqga--- * Bovine dqnnslppyaqglaspqgamtpgipifspmmpygtgltpqpiqntnsls---------------- * C_briggsae nmnspasrsmmggetpahg-gpssvlggpssil-tghgpnsvmgpnsilgpgsmv---------- * C_elegans -nlnspavsmlggdtpah-g-gpnsvlgg--------qgpssiltghgpnsv--m---gpnsilg * Candida_albicans ----------------------------------------------------------------- * Candida_glabrata ----------------------------------------------------------------- * Canis_lupus dqnnslppyaqglaspqgamtpgipifspmmpygtglt-pqpiqntnslslleeqqrqqq----- * Cryptococcus_neoformans ----------------------------------------------------------------- * Danio_rerio ----eqnnslppfaqglaspqgam-tpglpif-spmmpygtgltpqp----vqnsn--------- * Debaryomyces_hansenii ----------------------------------------------------------------- * D_melanogaster dqmlspnfsipsigtplhqmeadqqivanpvyhppavsqpdslmpapgsssvqhqqqqqqsdasg * Emericella_nidulans ----------------------------------------------------------------- * Encephalitozoon_cuniculi ----------------------------------------------------------------- * Eremothecium_gossypii ----------------------------------------------------------------- * Chicken dqnnslppyaqglaspqgamtpgipifspmmp--------------------------------- * Gibberella_zeae ---egiqthpsnaaqakaftapgslsf-pgat--neltpppv--------------gngdatqqp * Kluyveromyces_lactis ----------------------------------------------------------------- * Macaca_mulatta dqnnslppyaqglaspqgamtpgipifspmmpygtgltpqpiqntnslsileeqqr--------- * Mesocricetus_auratus dqnnslppyaqglaspqgamtpgipifspmmpygtgltpqpiqntnsl----------------- * Mouse dqnnslppyaqglaspqgamtpgipifspmmpygtgltpqpi----------------------- * Neurospora_crassa ----------------------------------------------------------------- * Onchocerca_volvulus ----------------------------------------------------------------- * Petromyzon_marinus ----dssgsmpgfspnlgs---------------------------------------------- * Pneumocystis_carinii ----------------------------------------------------------------- * Rat dqnnslppyaqglaspqgamtpgipifspmmpygtgltpqpvqntnsl----------------- * Schizosaccharomyces_pombe ----------------------------------------------------------------- * Strongylocentrotus_purpuratus ----------------------------------------------------------------- * Tetraodon_nigroviridis ----desaleryfedsiandsgflleeelsig-sptls--stylp-------------------- * Tribolium_castaneum ---------dqmlpsp-gfsipsi---------gtpl---------------------------- * Ustilago_maydis ----------------------------------------------------------------- * X_laevis ----dqnnsippf-qglaspqgs-ltpginif-splitygtgltpqp----vqttn--------- * X_tropicalis dqnnsippf-qglaspqgsltpginifsp------------------------------------ * Yarrowia_lipolytica ----------------------------------------------------------------- Dictyostelium_discoideum ----------------------------------------------------------------- Tetrahymena_thermophila ----------------------------------------------------------------- P Glycine_max ----------------------------------------------------------------- P Oryza_sativa ----------------------------------------------------------------- P Arabidopsis_thaliana-TBP2 ----------------------------------------------------------------- P Maize-TBP1 ----------------------------------------------------------------- P Maize-TBP1_VAR ----------------------------------------------------------------- P Maize-TBP2 ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 70 80 90 100 110 120 130 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= A PYRFU ----------------------------------------------------------------- A Pyrococcus_abyssi ----------------------------------------------------------------- ================================================================================================= * HUMAN ----------------------------------------------------------------- * S_CEREVISIAE ----------------------------------------------------------------- P ARABIDOPSIS_THALIANA ----------------------------------------------------------------- * 1JFIC_Human ----------------------------------------------------------------- * 1TBPA_S_cerevisiae ----------------------------------------------------------------- * Anopheles_gambiae ----------------------------------------------------------------- * Apis_mellifera ----------------------------------------------------------------- * Aspergillus_flavus ----------------dsltthpstaqqaraftspaslsfpggag---d-ltppsdkdgnmamnl * Aspergillus_fumigatus ngtvnghqqggnav--------------------------------------------------- * Bovine ----------------------------------------------------------------- * C_briggsae ----------------------------------------------------------------- * C_elegans pgsvl------------------------------------------------------------ * Candida_albicans ----------------------------------------------------------------- * Candida_glabrata ----------------------------------------------------------------- * Canis_lupus ---------------qqqqaqqqqaqqqqqqqqaqqqavtavqqstsqqatqgasgqtpqlfhsq * Cryptococcus_neoformans ----------------------------------------------------------------- * Danio_rerio ---------slslleeqqr------qqqqqqaasqqqggmvggsgqtpq-lyhstqavs------ * Debaryomyces_hansenii ----------------------------------------------------------------- * D_melanogaster gsglfghepslplahkqmqsyqpsasyqqqqqqqqlqsqapggggstpqsmmqpqtpqsmmahmm * Emericella_nidulans ----------------------------------------------------------------- * Encephalitozoon_cuniculi ----------------------------------------------------------------- * Eremothecium_gossypii ----------------------------------------------------------------- * Chicken ----------------------------------------------------------------- * Gibberella_zeae ph--ngqqaa------------------------------------------------------- * Kluyveromyces_lactis ----------------------------------------------------------------- * Macaca_mulatta ----------------------------------------------------------------- * Mesocricetus_auratus ----------------------------------------------------------------- * Mouse ----------------------------------------------------------------- * Neurospora_crassa ----------------------------------------------------------------- * Onchocerca_volvulus ----------------------------------------------------------------- * Petromyzon_marinus ----------------------------------------------------------------- * Pneumocystis_carinii ----------------------------------------------------------------- * Rat ----------------------------------------------------------------- * Schizosaccharomyces_pombe ----------------------------------------------------------------- * Strongylocentrotus_purpuratus ----------------------------------------------------------------- * Tetraodon_nigroviridis ----------------------------------------------------------------- * Tribolium_castaneum ----------------------------------------------------------------- * Ustilago_maydis ----------------------------------------------------------------- * X_laevis ---------slsileeqqr------qqqqtqqstlqqgnq--gsgqtpq-lfhp-qtl------- * X_tropicalis ----------------------------------------------------------------- * Yarrowia_lipolytica ----------------------------------------------------------------- Dictyostelium_discoideum ----------------------------------------------------------------- Tetrahymena_thermophila ----------------------------------------------------------------- P Glycine_max ----------------------------------------------------------------- P Oryza_sativa ----------------------------------------------------------------- P Arabidopsis_thaliana-TBP2 ----------------------------------------------------------------- P Maize-TBP1 ----------------------------------------------------------------- P Maize-TBP1_VAR ----------------------------------------------------------------- P Maize-TBP2 ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 140 150 160 170 180 190 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= A PYRFU ----------------------------------------------------------------- A Pyrococcus_abyssi ----------------------------------------------------------------- ================================================================================================= * HUMAN ---------------------qqqqq----qq----qqqq------qqq-------qqqqqqqq- * S_CEREVISIAE ----------------------------------------------ade-------erlkefke- P ARABIDOPSIS_THALIANA ---------------------tdqgl----eg----snpv------dls-------khp------ * 1JFIC_Human ----------------------------------------------------------------- * 1TBPA_S_cerevisiae ----------------------------------------------------------------- * Anopheles_gambiae ---------------------qpeed----qq----ilph------ayq-------qqqsmphm- * Apis_mellifera ---------------------qqqqq----qq----qqqq------qsq-------qqqqsqqqy * Aspergillus_flavus qgvnghvngqqqggnat----ngngv----tp----atpv-atp--gan-------tpg------ * Aspergillus_fumigatus ---------------------ngngv----tp----atpa-atp--gan-------apg------ * Bovine ---------------------ileeq----qr----qqqq------qqq-------qqqqqqqq- * C_briggsae ---------------------npqsi----qp----mqsh------qmh-------slqgssmq- * C_elegans ---------------------npqsi----qp----mqsq------qmh-------slqgssmq- * Candida_albicans ------------------------------------------------d-------lklpptnp- * Candida_glabrata ----------------------------------------------ade-------ermkefqe- * Canis_lupus tl-------------------ttapl----pg----ttplypspmtpmt---pitpatpases-- * Cryptococcus_neoformans ----------------------------------------------------------------- * Danio_rerio ---------------------tttal----pg----ntplytt---pltpmtpitpatpases-- * Debaryomyces_hansenii -----------------------------------------------ds-------lklpttaa- * D_melanogaster pmsersvggsgaggggdalsnihqtm----gp----stpm------tpa-------tpg------ * Emericella_nidulans ----------------------dslt----th----pata------qqa-------raftspss- * Encephalitozoon_cuniculi ---------------------dapdi----sy----ehqe------tsv-------pnr------ * Eremothecium_gossypii ----------------------------------------------sdd-------krlkefqe- * Chicken ---------------------ygtgl----tp----qpvq------stn-------slsileeq- * Gibberella_zeae ---------------------ngngv----ap----atpv-atp--aat-------qgp------ * Kluyveromyces_lactis ----------------------------------------------see-------nrmkqfqe- * Macaca_mulatta ---------------------qqqqq----qq----qqqq------qqq-------qqqqqqqq- * Mesocricetus_auratus ---------------------silee----qq----reqq------qqq-------qqqqqqqq- * Mouse ---------------------qntnslsilee----qqrq------qqq-------qqqqqqqq- * Neurospora_crassa ------------------------------------------------d-------aiqthpsn- * Onchocerca_volvulus ----------------------------------------------------------------- * Petromyzon_marinus ---------------------qqggm----tp----gmpl------fsp-------mmpygtgl- * Pneumocystis_carinii ----------------------------------------------------------------- * Rat ---------------------silee----qq----rqqq------qqq-------qqqqqqqq- * Schizosaccharomyces_pombe ----------------------------------------------------------------- * Strongylocentrotus_purpuratus ---------------------ynpsq----av----pvsl------hkn-------qdnqdggq- * Tetraodon_nigroviridis ----------------------------------------------gka-------glsrgsge- * Tribolium_castaneum ---------------------hqpee----dqmilpnalq------qqq-------qqqpstts- * Ustilago_maydis ---------------------dqqgl----s-----------------s-------vh------- * X_laevis ---------------------ttapl----pg----ntplypspitpmt---pispatpases-- * X_tropicalis ---------------------lmpyg----tg----ltpq------pvq-------ttnslsil- * Yarrowia_lipolytica ---------------------------------------------------------------d- Dictyostelium_discoideum -----------st--------attts----tp----aqnv------dls-------khp------ Tetrahymena_thermophila --------ssdktsqqtfklapnnsv----aq----snsi------dqn-------knk------ P Glycine_max ---------------------adqgl----eg----sqpv------dlq-------khp------ P Oryza_sativa --------aae----------aaaal----eg----sepv------dla-------khp------ P Arabidopsis_thaliana-TBP2 ---------------------adqgt----eg----sqpv------dlt-------khp------ P Maize-TBP1 ---------------------aepgl----ed----sqpv------dls-------khp------ P Maize-TBP1_VAR ---------------------aeprl----ed----sqpv------dls-------khp------ P Maize-TBP2 ---------------------aepgl----eg----sqpv------dls-------khp------ ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 200 210 220 230 240 250 260 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= A PYRFU ----------------------------------------------------------------- A Pyrococcus_abyssi ----------------------------------------------------------------- ================================================================================================= * HUMAN --qqqavaaaavqq-----s---tsqq-----at-q-gtsg---------q--ap-----ql-fh * S_CEREVISIAE --ankivfdpntrq-----v---wenq-----nr-d-gt-----------k--pa-----tt-fq P ARABIDOPSIS_THALIANA ----------------------------------------------------------------- * 1JFIC_Human ----------------------------------------------------------------- * 1TBPA_S_cerevisiae ----------------------------------------------------------------- * Anopheles_gambiae --tpmgglsssnyt-----m---paig-----st-s-gksm---------htyap-----sf-st * Apis_mellifera qlqqlhtmspniqsgmlmig---tpqknmhayat-t-ptfa---------t--pq-----sl-mq * Aspergillus_flavus ----------------------------------------------------------------- * Aspergillus_fumigatus ----------------------------------------------------------------- * Bovine --qqqqaavaavqq-----s---tsqq-----at-q-gpsg---------q--tp-----ql-fh * C_briggsae --mhshlansalnl-----n---inpa-----svgp-gnpgsvlhhnmdin--pp-----svayq * C_elegans --mhshlansnlnl-----n---inpa-----sv-g-pdrn---------p--gs-----vm-hh * Candida_albicans --tnpqqaktfmks-----i---eede-----kn-k-ae-----------d--ld-----ii-kk * Candida_glabrata --ankavfdpntrq-----v---wenq-----vn-k-te-----------d--da-----vk-pe * Canis_lupus ----------------------------------------------------------------- * Cryptococcus_neoformans ---------sglal-----p---kasn-----ag-p-ssss---------s--kp-----eg-iq * Danio_rerio ----------------------------------------------------------------- * Debaryomyces_hansenii --qakaftapnsll-----fplgidgq-----rt-d-in-----------q--ea-----tp-kk * D_melanogaster ----------------------------------------------------------------- * Emericella_nidulans --lsfpggtafpgg-----a---dltp-----ps-d-kdan---------m--at-----ng-qs * Encephalitozoon_cuniculi ----------------------------------------------------------------- * Eremothecium_gossypii --qnkivfdhstrs-----v---wenq-----dk-d-ss-----------m--gh-----lm-gg * Chicken --qrqqqqqqaaqs-----s---tsqq-----at-q-gtsg---------q--tp-----ql-fh * Gibberella_zeae ----------------------------------------------------------------- * Kluyveromyces_lactis --enkivfdpstrs-----v---wetq-----ek-q-e--------------------------h * Macaca_mulatta --qqqavaaaavqq-----s---tsqq-----tt-q-gtsg---------q--ap-----ql-fh * Mesocricetus_auratus --qavataaasvqq-----s---tsqq-----st-q-gasg---------q--tp-----ql-fh * Mouse --qavataaasvqq-----s---tsqq-----pt-q-gasg---------q--tp-----ql-fh * Neurospora_crassa --aaqakaftapgs-----l---sfpg-----aa-g-eltp---------p--ts-----ta-ns * Onchocerca_volvulus ----------------------------------------------------------------- * Petromyzon_marinus --tpqpvqgssmgm-----a---ddqq-----qp-qagtsq---------q--etgasqmqv-yq * Pneumocystis_carinii --------------------------------ap-s-slsf---------p--ss-----hi-lm * Rat --qavataaasvqq-----s---tsqq-----pt-q-gasg---------q--tp-----ql-fh * Schizosaccharomyces_pombe -------------------------df-----al-p-ttas---------q--as-----af-mn * Strongylocentrotus_purpuratus --qrshypqissqq-----s---qsyl-----sv-p-si-g------------tp-----s--fg * Tetraodon_nigroviridis --eldlsflpdelg-----t---qeep-----sr-h-nd-----------t--aq-----te-aq * Tribolium_castaneum --qsqqvpplapmg-----a---ltpt-----lg-l-gmgm---------s--mp-----htkya * Ustilago_maydis ----------------------------------------------------------------- * X_laevis ----------------------------------------------------------------- * X_tropicalis --eeqqrqqqqaqq-----s---tsqq-----gn-q-g-sg---------q--tp-----ql-fh * Yarrowia_lipolytica --alsaptnpaqaq-----q---fvtq-----n--n-ls-----------f--pq-----da--e Dictyostelium_discoideum ----------------------------------------------------------------- Tetrahymena_thermophila ----------------------------------------------------------------- P Glycine_max ----------------------------------------------------------------- P Oryza_sativa ----------------------------------------------------------------- P Arabidopsis_thaliana-TBP2 ----------------------------------------------------------------- P Maize-TBP1 ----------------------------------------------------------------- P Maize-TBP1_VAR ----------------------------------------------------------------- P Maize-TBP2 ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 270 280 290 300 310 320 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= A PYRFU ----------------------------------------------------------------- A Pyrococcus_abyssi ----------------------------------------------------------------- ================================================================================================= * HUMAN --s----------q-t---l--tta-plp-----g----------ttp----l---y-p------ * S_CEREVISIAE --s----------e-e---d--ikr-aap-----e----------sek----d---t-s------ P ARABIDOPSIS_THALIANA ----------------------------------------------------------------- * 1JFIC_Human ----------------------------------------------------------s------ * 1TBPA_S_cerevisiae ----------------------------------------------------------------- * Anopheles_gambiae --p----------q-n---miqpqt-pvs-----gldlvvsclllksv----lilsf-s----ap * Apis_mellifera --p----------q-tpqnm--msp-lvq-----n----------tnh----i---a-p------ * Aspergillus_flavus ----------------------------------------------------------------- * Aspergillus_fumigatus ----------------------------------------------------------------- * Bovine --s----------q-t---l--tta-plp-----g----------ttp----l---y-p------ * C_briggsae --n----------l-a---i--pmt-playnnfer----------dtl----m---h-p------ * C_elegans --nldinppsvayq-n---l--tvp-mtp-----l----------ays----v---ydr------ * Candida_albicans --e----------d-i---d--epk-qed-----t----------tdg----n---g-g------ * Candida_glabrata --a----------d-e---d-------------------------ede----d---d-a------ * Canis_lupus ----------------------------------------------------------------- * Cryptococcus_neoformans --t------------------------ld-----g----------egs----l---a-t------ * Danio_rerio ----------------------------------------------------------------- * Debaryomyces_hansenii --e----------e-d---t--sdtivep-----n----------qde----d---d-g------ * D_melanogaster ----------------------------------------------------------------- * Emericella_nidulans --a----------n-g---n--vng-qqq-----g----------ana----a---n-g------ * Encephalitozoon_cuniculi ----------------------------------------------------------------- * Eremothecium_gossypii --s----------v-v---q---se-skd-----s----------mda----d---h-g------ * Chicken --s----------q-t---l--tta-plp-----g----------ttp----l---y-p------ * Gibberella_zeae ----------------------------------------------------------------- * Kluyveromyces_lactis --e-----------------------slp-----g----------td------------------ * Macaca_mulatta --s----------q-t---l--tta-plp-----g----------ttp----l---y-p------ * Mesocricetus_auratus --s----------q-t---l--tta-plp-----g----------ttp----l---y-p------ * Mouse --s----------q-t---l--tta-plp-----g----------ttp----l---y-p------ * Neurospora_crassa --d----------k-s---a--avn-gai-----g----------aqa----a---n-g------ * Onchocerca_volvulus ----------------------------------------------------------------- * Petromyzon_marinus --t----------qgs---s--ttt-alp-----g----------cap----l---y-q------ * Pneumocystis_carinii --s----------g-a---m--ypg-srd-----e----------kgm----e---h-g------ * Rat --s----------q-t---l--tta-plp-----g----------ttp----l---y-p------ * Schizosaccharomyces_pombe --n----------s-s---l--tfp-vlp-----n----------ann--------e-a------ * Strongylocentrotus_purpuratus --s----------v-g---s--vss-lap-----g----------ssf----i---p-p------ * Tetraodon_nigroviridis aas----------q-d---s--avc-ldy-----n----------sqd----s---t-g------ * Tribolium_castaneum --g----------f-a---l--pit-siq-----s----------qtpqhtmm---s-pmvnlgg * Ustilago_maydis ----------------------------------------------------------------- * X_laevis ----------------------------------------------------------------- * X_tropicalis --p----------q-t---l--tta-plp-----g----------ntp----l---y-p------ * Yarrowia_lipolytica --a----------d-t---s--lig-evk-----r----------eqv----d-----s------ Dictyostelium_discoideum ----------------------------------------------------------------- Tetrahymena_thermophila ----------------------------------------------------------------- P Glycine_max ----------------------------------------------------------------- P Oryza_sativa ----------------------------------------------------------------- P Arabidopsis_thaliana-TBP2 ----------------------------------------------------------------- P Maize-TBP1 ----------------------------------------------------------------- P Maize-TBP1_VAR ----------------------------------------------------------------- P Maize-TBP2 ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 330 340 350 360 370 380 390 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= A PYRFU ----------------------------------------------------------------v A Pyrococcus_abyssi ----------------------------------------------------------------v ================================================================================================= * HUMAN ------sp-mtpmt-----------------------------------p-------itpatpas * S_CEREVISIAE ------at--------------------------------------------------------- P ARABIDOPSIS_THALIANA ----------------------------------------------------------------- * 1JFIC_Human ------hm--------------------------------------------------------- * 1TBPA_S_cerevisiae ----------------------------------------------------------------- * Anopheles_gambiae qqslm-sp-mvpmteskaaatpshpqsgsggsvrdpenigsvnihqtmgp-------atpmtpmt * Apis_mellifera ------ps-igpst-------pg--------------------------p-------mtpmtpas * Aspergillus_flavus ----------------------------------------------------------------- * Aspergillus_fumigatus ----------------------------------------------------------------- * Bovine ------sp-mtpmt-----------------------------------p-------itpatpas * C_briggsae ------pa-sniaa-----------------------------------t-------mvpatpas * C_elegans ------da-lthqa-----------------------------------pasniaatmvpatpas * Candida_albicans ------gg--------------------------------------------------------- * Candida_glabrata ------at--------------------------------------------------------- * Canis_lupus ----------------------------------------------------------------- * Cryptococcus_neoformans ------rp---pqk-----------------------------------a-------iasvpeit * Danio_rerio ----------------------------------------------------------------- * Debaryomyces_hansenii ------at--------------------------------------------------------- * D_melanogaster ----------------------------------------------------------------- * Emericella_nidulans ------ng-vmpat-----------------------------------p-------aatpgasa * Encephalitozoon_cuniculi ----------------------------------------------------------------- * Eremothecium_gossypii ------tt--------------------------------------------------------- * Chicken ------sp-mtpmt-----------------------------------p-------itpatpas * Gibberella_zeae ----------------------------------------------------------------- * Kluyveromyces_lactis -------------a-----------------------------------n-------aedadkgs * Macaca_mulatta ------sp-vtpmt-----------------------------------p-------itpatpas * Mesocricetus_auratus ------sp-mtpmt-----------------------------------p-------itpatpas * Mouse ------sp-mtpmt-----------------------------------p-------itpatpas * Neurospora_crassa ------ng-vtpat-----------------------------------pa------atpaanqg * Onchocerca_volvulus ------------------------------------------------------------dvps- * Petromyzon_marinus ------sp-mtpmt-----------------------------------p-------mtpitpas * Pneumocystis_carinii ------vv-stsln-----------------------------------q-------tatntfag * Rat ------sp-mtpmt-----------------------------------p-------itpatpas * Schizosaccharomyces_pombe ------tn-etads-----------------------------------g-------daevskne * Strongylocentrotus_purpuratus ------sp-maplt-----------------------------------p-------atpas--s * Tetraodon_nigroviridis ------aslsgggalnspfcpmtpmtpmtpmtpvter---------------------------- * Tribolium_castaneum ssgaantpsmgpat-------ps--------------------------p-------ltpmtphs * Ustilago_maydis ----------------------------------------------------------------- * X_laevis ----------------------------------------------------------------- * X_tropicalis ------sp-mtpmt-----------------------------------p-------itpatpas * Yarrowia_lipolytica ------gv--------------------------------------------------------- Dictyostelium_discoideum ----------------------------------------------------------------- Tetrahymena_thermophila ----------------------------------------------------------------- P Glycine_max ----------------------------------------------------------------- P Oryza_sativa ----------------------------------------------------------------- P Arabidopsis_thaliana-TBP2 ----------------------------------------------------------------- P Maize-TBP1 ----------------------------------------------------------------- P Maize-TBP1_VAR ----------------------------------------------------------------- P Maize-TBP2 ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 400 410 420 430 440 450 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxnxxxgivxxxxxxxxxxxxxxxPxLQNIVsTVNLxckLDLKtIALhARNAEYNPKxxxxxxRF ================================================================================================= A PYRFU dmS---kVk---------------lrIENIVaSVDLfaQLDLEkVldlcpNsKYNPE------eF A Pyrococcus_abyssi dtN---nVk---------------lrIENIVaSVDLfaQLDLEkVldicpNsKYNPE------eF ================================================================================================= * HUMAN esS---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * S_CEREVISIAE --S---GIV---------------PtLQNIVaTVtLgCRLDLKTVALHARNAEYNPK------RF P ARABIDOPSIS_THALIANA --S---GIV---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RF * 1JFIC_Human --S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * 1TBPA_S_cerevisiae --m---GIV---------------PtLQNIVaTVtLgCRLDLKTVALHARNAEYNPK------RF * Anopheles_gambiae pse--paIL---------------PqLQNIVSTVNLsCKLDLKkIALHARNAEYNPK------RF * Apis_mellifera adp---GIL---------------PqLQNIVSTVNLnCKLDLKkIALHARNAEYNPK------RF * Aspergillus_flavus --S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF * Aspergillus_fumigatus --S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF * Bovine esS---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * C_briggsae qlD---ipM---------------PaLQNIVSTVNLgvpLDLKkIALHARNAEYNPK------RF * C_elegans qlD---ipM---------------PaLQNIVSTVNLgvQLDLKkIALHARNAEYNPK------RF * Candida_albicans --i---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF * Candida_glabrata --S---GIV---------------PtLQNIVaTVNLgCRLDLKTVALHARNAEYNPK------RF * Canis_lupus --S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * Cryptococcus_neoformans avD---GLV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPR------RF * Danio_rerio --S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * Debaryomyces_hansenii --S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF * D_melanogaster --SadpGIV---------------PqLQNIVSTVNLcCKLDLKkIALHARNAEYNPK------RF * Emericella_nidulans pgS---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF * Encephalitozoon_cuniculi --S---GII---------------PtLQNVVaTVNLsCKLDLKnIALrARNAEYNPK------RF * Eremothecium_gossypii --S---GIV---------------PtLQNIVaTVNLdCRLDLKTVALHARNAEYNPK------RF * Chicken esS---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * Gibberella_zeae --S---GIt---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPKvhqtlrRF * Kluyveromyces_lactis atS---GII---------------PtLQNIVaTVNLdCRLDLKTVALHARNAEYNPK------RF * Macaca_mulatta esS---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * Mesocricetus_auratus esS---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * Mouse esS---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * Neurospora_crassa ptS---GMt---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF * Onchocerca_volvulus ------------------------PaLQNIVSTVNLgvpLDLKkIALHARNAEYNPK------RF * Petromyzon_marinus esS---GIV---------------PqLQNIVSTVNLcCKLDLKkIALHARNAEYNPK------RF * Pneumocystis_carinii -vS---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF * Rat esS---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * Schizosaccharomyces_pombe gvS---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF * Strongylocentrotus_purpuratus esS---GIV---------------PqLQNIVSTVNLnCRLDLKkIALHARNAEYNPK------RF * Tetraodon_nigroviridis --S---GII---------------PqLQNIVSTVNLgCpLDLKfIALqARNAEYNPK------RF * Tribolium_castaneum adp---nIV---------------PqLQNIVSTVNLsCKLDLKkIALHARNAEYNPK------RF * Ustilago_maydis ------GIV---------------PtLQNIVaTVNLevRLDLKTIALHARNAEYNPK------RF * X_laevis --S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * X_tropicalis esS---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RF * Yarrowia_lipolytica --S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RF Dictyostelium_discoideum --S---GII---------------PtLQNIVSTVNMatELyLKaIALgARNAEYNPK------RF Tetrahymena_thermophila --N---nILstietmdksisedlyPkLQNIVSTVNLstKLDLKqIALrARNAEYNPK------RF P Glycine_max --S---GIV---------------PtLQNIVSTVNLdCKLDLKTIALqARNAEYNPK------RF P Oryza_sativa --S---GII---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RF P Arabidopsis_thaliana-TBP2 --S---GIV---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RF P Maize-TBP1 --S---GIV---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RF P Maize-TBP1_VAR --S---GIV---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RF P Maize-TBP2 --S---GIV---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RF ================================================================================================= Consensus xxnxxxgivxxxxxxxxxxxxxxxPxLQNIVsTVNLxckLDLKtIALhARNAEYNPKxxxxxxRF 460 470 480 490 500 510 520 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus AAVIMRIREPKTTALIFxSGKMVcTGAKSEEnSKlAaRKYAQIIQKLGFxaxKFxEFkIQNIVgS ================================================================================================= A PYRFU pgIIchLdDPKvalLIFsSGKLVvTGAKSvQDiErAvaKlAQkLKsIGvkfkRapQidVQNMVfS A Pyrococcus_abyssi pgIIcRfdDPKvalLIFsSGKLVvTGAKSihDiErAvaKliEkLKgIGvkfkRaplidIQNMVfS ================================================================================================= * HUMAN AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * S_CEREVISIAE AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFaA-KFtDFKIQNIVGS P ARABIDOPSIS_THALIANA AAVIMRIREPKTTALIFaSGKMVCTGAKSEDfSKMAARKYARIVQKLGFpA-KFkDFKIQNIVGS * 1JFIC_Human AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * 1TBPA_S_cerevisiae AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFaA-KFtDFKIQNIVGS * Anopheles_gambiae AAVIMRIREPRTTALIFsSGKMVCTGAKSEDDSRLAARKYARIIQKLGFtA-KFlDFKVQNMVGS * Apis_mellifera AAVIMRIREPRTTALIFsSGKMVCTGAKSEEDSRLAARKYARIIQKLGFpA-KFlDFKIQNMVGS * Aspergillus_flavus AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS * Aspergillus_fumigatus AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS * Bovine AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * C_briggsae AAVIMRIREPRTTALIFsSGKMVCTGAKSEEaSRLAARKYARIVQKLGFqA-KFtEFmVQNMVGS * C_elegans AAVIMRIREPRTTALIFsSGKMVCTGAKSEEaSRLAARKYARIVQKLGFqA-KFtEFmVQNMVGS * Candida_albicans AAVIMRIRDPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFcDFKIQNIVGS * Candida_glabrata AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFaA-KFtDFKIQNIVGS * Canis_lupus AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Cryptococcus_neoformans AAVVMRIRDPRTTALIFaSGKMVvTGAKSEDDSRLAsRKYARIIQKLGFeA-KFaEFKIQNMVGS * Danio_rerio AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Debaryomyces_hansenii AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS * D_melanogaster AAVIMRIREPRTTALIFsSGKMVCTGAKSEDDSRLAARKYARIIQKLGFpA-KFlDFKIQNMVGS * Emericella_nidulans AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS * Encephalitozoon_cuniculi AAVIMRIREPKTTALIFaSGKMViTGAKSEKSSRMAAQRYAKIIhKLGFnA-tFdDFKIQNIVsS * Eremothecium_gossypii AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFsA-KFtDFKIQNIVGS * Chicken AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Gibberella_zeae AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS * Kluyveromyces_lactis AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFsA-KFtDFKIQNIVGS * Macaca_mulatta AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Mesocricetus_auratus AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Mouse AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Neurospora_crassa AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS * Onchocerca_volvulus AAVIMRIREPRTTALIFsSGKMVCTGAKSEESSRLAARKYARIVQKLGFnA-KFtEFKVQNMVGS * Petromyzon_marinus AAVIMRIREPRTTALIFsSGKMVCTGAKSEDqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Pneumocystis_carinii AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS * Rat AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Schizosaccharomyces_pombe AAVIMRIREPKSTALIFaSGKMVvlGgKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS * Strongylocentrotus_purpuratus AAVIMRIREPRTTALIFsSGKMVCTGAKrEDNSRLAARKYARVVQKLGFaA-KFlDFKIQNMVGS * Tetraodon_nigroviridis AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-RFlDFKIQNMVaS * Tribolium_castaneum AAVIMRIREPRTTALIFsSGKMVCTGAKSEDDSRLAARKYARIIQKLGFpA-KFlDFKIQNMVGS * Ustilago_maydis AAVIMRIREPKTTALIFaSGKMVvTGAKSEDDSRLAsRKYARIIQKLGFeA-KFsEFKIQNIVGS * X_laevis AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * X_tropicalis AAVIMRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGS * Yarrowia_lipolytica AAVIMRIREPKTTALIFaSGKMVvTGARSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGS Dictyostelium_discoideum AAVIMRIREPKTTALIFkSGKMVCTGAKSEDaSRfAARKYARIIQKLdFpA-RFtDFKIQNIVGS Tetrahymena_thermophila AAVIMRLRDPKTTALIFaSGKMVCTGAKTEEDSnrAARKYAKIIQKIGFpv-QFkDFKIQNIVGS P Glycine_max AAVIMRIRDPKTTALIFaSGKMVCTGAKSEQqSKLAARKYARIIQKLGFpA-KFkDFKIQNIVGS P Oryza_sativa AAVIMRIREPKTTALIFaSGKMVCTGAKSEQqSKLAARKYARIIQKLGFpA-KFkDFKIQNIVGS P Arabidopsis_thaliana-TBP2 AAVIMRIREPKTTALIFaSGKMVCTGAKSEhlSKLAARKYARIVQKLGFpA-KFkDFKIQNIVGS P Maize-TBP1 AAVIMRIREPKTTALIFaSGKMVCTGAKSEQqSKLAARKYARIIQKLGFpA-KFkDFKIQNIVGS P Maize-TBP1_VAR AAVIMRIREPKTTALIFaSGKMVCTGAKSEQqSKLAARKYARIIQKLGFpA-KFkDFKIQNIVGS P Maize-TBP2 AAVIMRIREPKTTALIFaSGKMVCTGAKSEQqSKLAARKYARIIQKLGFpA-KFkDFKIQNIVGS ================================================================================================= Consensus AAVIMRIREPKTTALIFxSGKMVcTGAKSEEnSKlAaRKYAQIIQKLGFxaxKFxEFkIQNIVgS 530 540 550 560 570 580 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus cDVkFpIrLEgLxxsHxxFssYEPELFPGLIYRMiqPKIVLLIFVSGKIVLTGAKvKeDiyeAFd ================================================================================================= A PYRFU gDIgrefnLDvValTlp-nceYEPEqFPGVIYRVkEPKsVILLFsSGKIVcSGAKsEaDaWEAvr A Pyrococcus_abyssi gDIgrefnLDnValTlp-nceYEPEqFPGVIYRVkdPRaVILLFsSGKIVcSGAKsEaDaWEAvr ================================================================================================= * HUMAN CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * S_CEREVISIAE CDVKFPIRLEGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFE P ARABIDOPSIS_THALIANA CDVKFPIRLEGLaySHaaFSSYEPELFPGLIYRMkvPKIVLLIFVSGKIVITGAKMRDEtYKAFE * 1JFIC_Human CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * 1TBPA_S_cerevisiae CDVKFPIRLEGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFE * Anopheles_gambiae CDVRFPIRLEGLvlTHgrFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYDAFE * Apis_mellifera CDVKFPIRLEGLvlTHgqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYEAFD * Aspergillus_flavus CDIKFPIRLEGLasrHhnFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFE * Aspergillus_fumigatus CDIKFPIRLEGLasrHhnFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFE * Bovine CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * C_briggsae CDVRFPIQLEGLciTHaqFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVVITGAKtKKDIdDAFg * C_elegans CDVRFPIQLEGLciTHsqFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVVITGAKtKrDIdEAFg * Candida_albicans tDVKFaIRLEGLafaHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKkREEIYDAFE * Candida_glabrata CDVKFPIRLEGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFE * Canis_lupus CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * Cryptococcus_neoformans CDVKFPIRLEGLafSHgaFSSYEPELFPGLIYRMLKPKVVILIFVSGKIVLTGAKVREEIYmAFN * Danio_rerio CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRgEIYEAFE * Debaryomyces_hansenii CDVKFPIRLEGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYaAFE * D_melanogaster CDVKFPIRLEGLvlTHcnFSSYEPELFPGLIYRMVRPRIVLLIFVSGKVVLTGAKVRQEIYDAFD * Emericella_nidulans CDIKFPIRLEGLasrHhnFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFE * Encephalitozoon_cuniculi CDIKFsIRLEGLayaHsnYcSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKVRDDIYQAFN * Eremothecium_gossypii CDVKFPIRLEGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFE * Chicken CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * Gibberella_zeae CDIKFPIRLEGLasrHhnFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFE * Kluyveromyces_lactis CDVKFPIRLEGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFE * Macaca_mulatta CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * Mesocricetus_auratus CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * Mouse CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * Neurospora_crassa CDIKFPIRLEGLaskHhnFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFE * Onchocerca_volvulus CDVRFPIQLEGLclTHtqFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVVITGAKyKKDIdDAFN * Petromyzon_marinus CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRgEIYEAFE * Pneumocystis_carinii CDVKFPIRLEGLaySHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKVREEIYQAFE * Rat CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * Schizosaccharomyces_pombe CDVKFPIRLEGLaySHgtFSSYEPELFPGLIYRMVKPKVVLLIFVSGKIVLTGAKVREEIYQAFE * Strongylocentrotus_purpuratus CDVKFPIRLEGLvlTHgqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYDAFN * Tetraodon_nigroviridis CDVcFPIRLEGLvlTHqqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKeRaEIYEAFE * Tribolium_castaneum CDVKFPIRLEGLvlTHssFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKIRQEIYEAFD * Ustilago_maydis CDVRFPIRLEGLaySHgvYSSYEPELFPGLIYRMVKPKVVLLIFVSGKIVLTGAKVREEIYQAFN * X_laevis CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * X_tropicalis CDVKFPIRLEGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFE * Yarrowia_lipolytica CDVKFPIRLEGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYaAFE Dictyostelium_discoideum CDVKFPIKLElLhnaHtsFTNYEPEIFPGLIYKMIQPKVLLLIFVSGKIVLTGAKVREyIYEAFE Tetrahymena_thermophila tDVKFPInLDhLeqdHkkFvqYEPEIFPGkIYRefntKIVLLIFVSGKIVLTGAKtRENInKAFq P Glycine_max CDVKFPIRLEGLaySHgaFSSYEPELFPGLIYRMkQPKIVLLIFVSGKIVLTGAKVRDEtYtAFE P Oryza_sativa CDVKFPIRLEGLaySHgaFSSYEPELFPGLIYRMkQPKIVLLIFVSGKIVLTGAKVRDEtYtAFE P Arabidopsis_thaliana-TBP2 CDVKFPIRLEGLaySHsaFSSYEPELFPGLIYRMklPKIVLLIFVSGKIVITGAKMREEtYtAFE P Maize-TBP1 CDVKFPIRLEGLaySHgaFSSYEPELFPGLIYRMkQPKIVLLIFVSGKIVLTGAKVREEtYtAFE P Maize-TBP1_VAR CDVKFPIRLEGLaySHgaFSSYEPELFPGLIYRMkQPKIVLLIFVSGKIVLTGAKVREEtYtAFE P Maize-TBP2 CDVKFPIRLEGLaySHgaFSSYEPELFPGLIYRMkQPKIVLLIFVSGKIVLTGAKVREEtYtAFE ================================================================================================= Consensus cDVkFpIrLEgLxxsHxxFssYEPELFPGLIYRMiqPKIVLLIFVSGKIVLTGAKvKeDiyeAFd 590 600 610 620 630 640 650 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xIfpVLqxxxxxfrkxxxxxxxxxxxxxxxxxxxxxxxxxxx ========================================================================== A PYRFU kLlreLdk-------yglleeeeeel---------------- A Pyrococcus_abyssi kLlreLEk-------yglieeeeeel---------------- ========================================================================== * HUMAN nIYPILKg----FRKtt------------------------- * S_CEREVISIAE aIYPVLse----FRKm-------------------------- P ARABIDOPSIS_THALIANA nIYPVLse----FRKiqq------------------------ * 1JFIC_Human nIYPILKg----FRKt-------------------------- * 1TBPA_S_cerevisiae aIYPVLse----FRKm-------------------------- * Anopheles_gambiae nIYPILKs----FKKq-------------------------- * Apis_mellifera nIYPILKs----FKKq-------------------------- * Aspergillus_flavus lIYPVLsd----FRKv-------------------------- * Aspergillus_fumigatus lIYPVLsgtvilFfgfks-----nymltirsd--frkv---- * Bovine nIYPILKg----FRKtt------------------------- * C_briggsae qIYPILKg----FKK--------------------------- * C_elegans qIYPILKg----FKK--------------------------- * Candida_albicans sIYPVLne----FRKn-------------------------- * Candida_glabrata aIYPVLse----FRKm-------------------------- * Canis_lupus nIYPILKg----FRKtt------------------------- * Cryptococcus_neoformans qIYsVLle----FRKtt------------------------- * Danio_rerio nIYPILKg----FRKts------------------------- * Debaryomyces_hansenii aIYPVLse----FRKs-------------------------- * D_melanogaster kIFPILKk----FKKqs------------------------- * Emericella_nidulans lIYPVLsd----FRKv-------------------------- * Encephalitozoon_cuniculi nIYPVLiq----hRKa-------------------------- * Eremothecium_gossypii aIYPVLse----FRKl-------------------------- * Chicken nIYPILKg----FRKtt------------------------- * Gibberella_zeae mIYPVLQg----lRchhiisypthhiitilstcmirhkpsry * Kluyveromyces_lactis aIYPVLse----FRKl-------------------------- * Macaca_mulatta nIYPILKg----FRKtt------------------------- * Mesocricetus_auratus nIYPILKg----FRKtt------------------------- * Mouse nIYPILKg----FRKtt------------------------- * Neurospora_crassa mIYPVLQd----FRKv-------------------------- * Onchocerca_volvulus qIYPILKg----FKK--------------------------- * Petromyzon_marinus nIYPILKg----FRKtt------------------------- * Pneumocystis_carinii aIYPVLse----FRKss------------------------- * Rat nIYPILKg----FRKtt------------------------- * Schizosaccharomyces_pombe aIYPVLse----FRKh-------------------------- * Strongylocentrotus_purpuratus nIYPILKs----FKKts------------------------- * Tetraodon_nigroviridis nIYPILRg----FRKq-------------------------- * Tribolium_castaneum nIYPILKs----FKKq-------------------------- * Ustilago_maydis lIlPVLae----FRKp-------------------------- * X_laevis nIYPILKg----FRKtt------------------------- * X_tropicalis nIYPILKg----FRKtt------------------------- * Yarrowia_lipolytica aIYPVLne----FRKg-------------------------- Dictyostelium_discoideum nIYPVLsa----FKKvna--------itq------------- Tetrahymena_thermophila kIYwVLyn----YQKkdy-------rganlhnqnlnikpsik P Glycine_max nIYPVLte----FRKnqq------------------------ P Oryza_sativa nIYPVLte----FRKvqq------------------------ P Arabidopsis_thaliana-TBP2 nIYPVLRe----FRKvqq------------------------ P Maize-TBP1 nIYPVLae----FRKvqq------------------------ P Maize-TBP1_VAR nIYPVLae----FRKvqq------------------------ P Maize-TBP2 nIYPVLse----FRKiqq------------------------ ========================================================================== Consensus xIfpVLqxxxxxfrkxxxxxxxxxxxxxxxxxxxxxxxxxxx
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