ADH1

                                  150       160       170       180       190       200       210
                           ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                  hHFLGtSTFSQYTVVNExAVAKIDaAaPLEKVCLIGCGFSTGYGsAVkvAKVtPGSTCAVFGLGGVGLSv
=================================================================================================
GADUS_MORHUA               lqFLGTSTFSQYTVVNQiAVAKIDpsAPLDtVCLLGCGvSTGFGaAVntAKVePGSTCAVFGLGaVGLaa
Danio_rerio                lqFMGTSTFSEYTVINQnAVAKIDenAPLDRVfLLGCGiTTGYGaAVntAgVTPGSvCAVFGLGaVGLaa
Oryzias_latipes            lqFMGaSTFSEYTVMNQiAVAKIDpAAPLDKVCLLGCGvcTGFGaAVntAKVePGSTCAVFGLGaVGLaa
=================================================================================================
HORSE                      HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGVGLSV
HUMAN                      HHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGCGFSTGYGSAVnVAKVTPGSTCAVFGLGGVGLSa
1A71A_Horse                HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGaGLSV
1AXEA_Horse                HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGVGLSV
1AXGA_Horse                HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGaGLSV
1JU9A_Horse                HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGVGLSV
1MGOA_Horse                HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGVGLSV
1N8KA_Horse                HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGVGLSV
1QLHA_Horse                HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGVGLSV
1QV6A_Horse                HHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGCGFSTGYGSAVKVAKVTqGSTCAVFGLGGVGLSV
1HDYA_Human                HHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGCGFSTGYGSAVnVAKVTPGSTCAVFGLGGVGLSa
1HDZA_Human                HHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGCGFSTGYGSAVnVAKVTPGSTCAVFGLGGVGLSa
1HSOA_Human                HHFLGiSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGCGFSTGYGSAVnVAKVTPGSTCAVFGLGGVGLSa
1HTBA_Human                HHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGCGFSTGYGSAVnVAKVTPGSTCAVFGLGGVGLSa
Alligator_mississippiensis HHFIGTSTFTEYTVVHEtAVARIDAAAPLEKVCLIGCGFSTGYGaAVKdAKVePGSTCAVFGLGGVGLSt
Apteryx_australis          HHFIGTSTFTEYTVVHEtAVAKIaAAAPLEKVCLIGCGFSTGYGaAVQtAKVePGSTCAVFGLGGVGLSV
Canis_lupus                yHFLGiSTFSQYTVVDEfsVAKIDAAsPLEKVCLIGCGFSTGYGSAVnVAKVTPGSTCAVFGLGGVGLSV
Coturnix_coturnix          HHFIGTSTFTEYTVVHEtAaAKIDsAAPLEKVCLIGCGFSTGYGavLQtAKVePGSTCAVFGLGGVGLSV
Gallus_gallus              HHFVGTSTFTEYTVVHEtAaAKIDsAAPLEKVCLIGCGFSTGYGavLQtAKVeaGSTCAVFGLGGVGLSV
Macaca_mulatta             HHFLGvSTFSQYTVVDEnAVAKIDAAsPMEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSa
Mus_musculus               HNFIsTSTFSQYTVVDDiAVAKIDgAsPLDKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSV
Oryctolagus_cuniculus      HHFIGTSTFSQYTVVDEiAVAKIDAAAPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSV
Pan_troglodytes            HHFLGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGCGFSTGYGSAVnVAKVTPGSTCAVFGLGGVGLSa
Papio_hamadryas            HHFVGTSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGCGFSTGYGSAVnVAKVTPGSvCAVFGLGGVGLSa
Pongo_pygmaeus             HHFLGiSTFSQYTVVDEnAVAKIDAAsPLaKVCLIGCGFSTGYGSAVnVAKVTPGSTCAVFGLGGVGLSV
Rattus_norvegicus          HHFIsTSTFSQYTVVDDiAVAKIDAAAPLDKVCLIGCGFSTGYGSAVQVAKVTPGSTCAVFGLGGVGLSV
Struthio_camelus           HHFaGTSTFTEYTVLHEtAVAKIDAAAPLEKVCLIGCGFSTGYGaALQtAKVePGSTCAVFGLGGVGLSV
=================================================================================================
Consensus                  hHFLGtSTFSQYTVVNExAVAKIDaAaPLEKVCLIGCGFSTGYGsAVkvAKVtPGSTCAVFGLGGVGLSv

Page 3 of 6