10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVQAVCVLKGExxxxxxxxxxxxxxxxVQGt ================================================================================================ BOVINE -------------------a--------------------tKAVCVLKGD--g------------pVQGT HUMAN -------------------a--------------------tKAVCVLKGD--g------------pVQGi XENLA ----------------------------------------VKAVCVLaGs--g------------dVKGv 1CB4A_Bovine -------------------a--------------------tKAVCVLKGD--g------------pVQGT 1E9OA_Bovine -------------------a--------------------tsAVCVLsGD--g------------pVQGT 1E9OB_Bovine -------------------a--------------------tKAVCVLKGD--g------------pVQGT 1E9PA_Bovine -------------------a--------------------tsAVCVLsGD--g------------pVQGT 1E9PB_Bovine -------------------a--------------------tsAVCVLsGD--g------------pVQGT 3SODO_Bovine -------------------a--------------------tKAVaVLKGD--g------------pVQGT 1AZVA_Human -------------------a--------------------tKAVCVLKGD--g------------pVQGi 1FUNA_Human -------------------a--------------------tKAVaVLKGD--g------------pVQGi 1L3NA_Human -------------------a--------------------tKAVaVLKGD--g------------pVQGi 1N19A_Human -------------------a--------------------tKvVaVLKGD--g------------pVQGi 1PTZA_Human -------------------a--------------------tKAVaVLKGD--g------------pVQGi Apis_mellifera ----------------------------------------tKAVCVLQGE----------------VKGT Canis_lupus -------------------e--------------------MKAVCVLKGQ--g------------pVEGT Capra_hircus -------------------a--------------------tKAVCVLKGD--g------------pVQGT Cavia_porcellus -------------------a--------------------tKAVCVLKGD--g------------pVQGi Cebus_apella -------------------a--------------------MKAVCVLKGD--g------------pVQGT Cervus_elaphus -------------------a--------------------tKAVCVLKGD--g------------pVQGT Chelonia_mydas ----------------a--t--------------------VKAVCVLKGE--dpvkepvkgpvkepVKGi Danio_rerio -------------------v--------------------nKAVCVLKGt--g------------eVtGT Equus_caballus -------------------a--------------------LKAVCVLKGD--g------------pVhGv Gallus_gallus ----------------a--t--------------------LKAVCVMKGD--a------------pVEGv Hylobates_lar -------------------a--------------------MKAVCVLKGD--s------------pVQGi Macaca_mulatta -------------------a--------------------MKAVCVLKGD--s------------pVQGT Mus_musculus -------------------a--------------------MKAVCVLKGD--g------------pVQGT Oncorhynchus_mykiss -------------------a--------------------MKAVCVLKGt--g------------eVtGT Oryctolagus_cuniculus -------------------a--------------------tKAVCVLKGD--g------------pVEaT Ovis_aries -------------------a--------------------tKAVCVLKGD--g------------pVQGT Pongo_pygmaeus -------------------a--------------------tKAVCVLKGD-ns------------pVKGi Rattus_norvegicus -------------------a--------------------MKAVCVLKGD--g------------pVQGv Sus_scrofa -------------------a--------------------tKAVCVLKGD--g------------pVQGT Tetraodon_nigroviridis pasavlpcvsflevttakmv--------------------IKAVCVLKGa--g------------etsGT Xenopus_tropicalis ----------------------------------------VRAVCVLaGs--g------------dVKGv ================================================================================================ SCHISTOSOMA_MANSONI -----------------gsn--------------------MKAVCVMtGt--a------------gVKGv Schistosoma_japonicum -----------------------------------------KAVCVMsGs--a------------gVKGv ================================================================================================ YEAST ----------------------------------------VQAVaVLKGD--a------------gVsGv 1B4TA_Yeast ----------------------------------------VQAVaVLKGD--a------------gVsGv 1F18A_Yeast ----------------------------------------VQAVaVLKGD--a------------gVsGv 1F1AA_Yeast ----------------------------------------VQAVaVLKGD--a------------gVsGv 1F1DA_Yeast ----------------------------------------VQAVaVLKGD--a------------gVsGv 1JK9C_Yeast ----------------------------------------VQAVaVLKGD--a------------gVsGv Aspergillus_flavus ----------------------------------------VKAVaVLRGD--s------------kIsGT Aspergillus_fumigatus ----------------------------------------VKAVaVLRGD--s------------kItGT Candida_albicans ----------------------------------------VKAVaVVRGD--s------------kVQGT Candida_glabrata ----------------------------------------VKAVaVLRGs--a------------gVsGv Cryptococcus_neoformans ----------------------------------------VKAVaVLKGD--s------------yVhGT Debaryomyces_hansenii ----------------------------------------aKAVaVLRGD--s------------kVsGv Emericella_nidulans ----------------------------------------VKAVaVLRGD--s------------kVsGT Eremothecium_gossypii vkaskywrwwlggngsilt---------------------VKAVaVLKGD--a------------gVsGv Gibberella_zeae iklth-----------------------------------slAVsVLRGD--s------------kVsGT Kluyveromyces_lactis ----------------------------------------VnAVaVLKGD--s------------sVsGi Neurospora_crassa ----------------------------------------VKAVaVVRGD--s------------nVKGT Schizosaccharomyces_pombe ----------------------------------------VRAVaVLRGD--s------------kVsGv Yarrowia_lipolytica ----------------------------------------VKAVaVLRGD--s------------kVsGT ================================================================================================ PHOTOBACTERIUM_LEIOGNATHI -------------------nkaktllftalafglshqalaqdltvkMtdlqtg------------kpvGT Vibrio_splendidus ---------------------nkttwlaalal-isspvfaevvnveMidlgsg------------qstGT ================================================================================================ Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVQAVCVLKGExxxxxxxxxxxxxxxxVQGt 80 90 100 110 120 130 140 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus IxFExxQExxxxxxxxPVxLSGeISGLxexGEHGFHVHQFGDNTSxxxxxxxxGCTSAGPHFNPxNKxEH ================================================================================================ BOVINE IhFE--aK--g--d--tVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH HUMAN InFE--QK--esng--PVkVwGsIkGLtE-GlHGFHVHEFGDNTa--------GCTSAGPHFNPlSR-KH XENLA VhFE--QQ--de-g--aVsVeGKIeGLtD-GlHGFHIHvFGDNTN--------GCmSAGsHFNPeNK-nH 1CB4A_Bovine IhFE--aK--g--d--tVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH 1E9OA_Bovine IhFE--aK--g--d--tVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH 1E9OB_Bovine IhFE--aK--g--d--tVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH 1E9PA_Bovine IhFE--aK--g--d--tVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH 1E9PB_Bovine IhFE--as--g--d--tVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH 3SODO_Bovine IhFE--aK--g--d--tVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH 1AZVA_Human InFE--QK--esng--PVkVwGsIkrLtE-GlHGFHVHEFGDNTa--------GCTSAGPHFNPlSR-KH 1FUNA_Human InFE--QK--esng--PVkVwGsIkGLtE-GlHGFHVHEFGDNTa--------GCTSAGPHFNPlSR-KH 1L3NA_Human InFE--QK--esng--PVkVwGsIkGLtE-GlHGFHVHEFGDNTa--------GCTSAGPHFNPlSR-KH 1N19A_Human InFE--QK--esng--PVkVwGsIkGLtE-GlHGFHVHEFGDNTa--------GCTSAGPHFNPlSR-KH 1PTZA_Human InFE--QK--esng--PVkVwGsIkGLtE-GlrGFHVHEFGDNTa--------GCTSAGPHFNPlSR-KH Apis_mellifera IfFEqpEs--t--n--sVkVTGQVTGLkK-GlHGFHVHEFGDNTN--------GCTSAGaHFNPlgK-DH Canis_lupus IhFv--QK--gs-g--PVvVSGtITGLtE-GEHGFHVHQFeDxTq--------GCTSAGPHFNPlSK-KH Capra_hircus IhFE--aK--g--d--kVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH Cavia_porcellus IhFE--QK---ang--PVvVkGrITGLvE-GKHGFHVHEFGDNTq--------GCTSAGPHFNPlSK-KH Cebus_apella InFE--QKesn--g--PVkVwGsITGLaE-GlHGFHVHQFGDNTq--------GCTSAGPHFNPlSR-KH Cervus_elaphus IrFE--aK--g--h--tVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH Chelonia_mydas IyFE--QQ--g--n-gPVtLSGsITGLtE-GKHGFHVHEFGDNTN--------GCTSAGaHFNPpgK-nH Danio_rerio VyFn--QE--g--ekkPVkVTGEITGLtp-GKHGFHVHaFGDNTN--------GCiSAGPHFNPhDK-tH Equus_caballus IhFEqqQE--g--g--PVvLkGfIeGLtK-GDHGFHVHEFGDNTq--------GCTTAGaHFNPlSK-KH Gallus_gallus IhFQ--Q---qgsg--PVkVTGKITGLsD-GDHGFHVHEFGDNTN--------GCTSAGaHFNPegK-QH Hylobates_lar InFE--QKesn--g--PVkVyGrITGLtE-GlHGFHVHQFGDNTq--------GCTSAGPHFNPlSR-KH Macaca_mulatta InFE--QKesn--g--PVkVwGsITGLtE-GlHGFHVHQFGDNTq--------GCTSAGPHFNPlSR-QH Mus_musculus IhFE--QKasg--e--PVvLSGQITGLtE-GQHGFHVHQYGDNTq--------GCTSAGPHFNPhSK-KH Oncorhynchus_mykiss VfFE--QE--gadg--PVkLiGEISGLap-GEHGFHVHaYGDNTN--------GCmSAGPHFNPhNQ-tH Oryctolagus_cuniculus IhFE--QK---gtg--PVvVkGrITGLtE-GlHeFHVHQFGDNrq--------GCTSAGPHFNPlSK-KH Ovis_aries IrFE--aK--g--d--kVvVTGsITGLtE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPlSK-KH Pongo_pygmaeus InFE--QKern--g--PVkVwGsIeGLtE-GlHGFHVHEFGDNTv--------GCTSAGPHFNPlSR-KH Rattus_norvegicus IhFE--QKasg--e--PVvVSGQITGLtE-GEHGFHVHQYGDNTq--------GCTTAGPHFNPhSK-KH Sus_scrofa IyFE--lK---gek--tVlVTGtIkGLaE-GDHGFHVHQFGDNTq--------GCTSAGPHFNPeSK-KH Tetraodon_nigroviridis VyFE--QQ--d--ekaPVkLTGEIkGLta-GEHGFHVHaFGDNTN--------GCiSAGPHYNPhNK-tH Xenopus_tropicalis VhFQ--QQ--d-eg--PVtVeGKIyGLtD-GKHGFHIHEFGDNTN--------GCiSAGPHFNPeSK-tH ================================================================================================ SCHISTOSOMA_MANSONI VkFt--QE--tdng--PVhVhaEfSGLka-GKHGFHVHEFGDtTN--------GCTSAGaHFNPtkQ-EH Schistosoma_japonicum VnFt--QD--ttdg--PVhIhGEfSGLkp-GKHGFHVHEFGDtTN--------GCTSAGaHFNPtNQ-EH ================================================================================================ YEAST VkFE--Qa--sese--PttVSyEIaGnspnaErGFHIHEFGDaTN--------GCvSAGPHFNPfkK-tH 1B4TA_Yeast VkFE--Qa--sese--PttVSyEIaGnspnaErGFHIcEFGDaTN--------GCvSAGPHFNPfkK-tH 1F18A_Yeast VkFE--Qa--sese--PttVSyEIaGnspnaErGFHIHEFGDaTN--------GCvSAGPHFNPfkK-tH 1F1AA_Yeast VkFE--Qa--sese--PttVSyEIaGnspnaErGFHIqEFGDaTN--------GCvSAGPHFNPfkK-tH 1F1DA_Yeast VkFE--Qa--sese--PttVSyEIaGnspnaErGFcIHEFGDaTN--------GCvSAGPHFNPfkK-tH 1JK9C_Yeast VkFE--Qa--sese--PttVSyEIaGnspnaErGFHIfEFGDaTN--------GCvSAGPHFNPfkK-tH Aspergillus_flavus VtFE--Qa--dana--PttVSwnITGhdanaEraFHVHQFGDNTN--------GCTSAGPHFNPfgK-EH Aspergillus_fumigatus VtFE--Qa--dens--PttVSwnIkGndpnaKrGFHVHQFGDNTN--------GCTSAGPHFNPygK-tH Candida_albicans VhFE--QE--sesa--PttISwEIeGndpnalrGFHIHQFGDNTN--------GCTSAGPHFNPfgK-QH Candida_glabrata VtlE--Qa--seqd--PttITyEIaGndpnaErGFHIHEFGDvTN--------GCvSAGPHFNPfkK-tH Cryptococcus_neoformans ItFt--QE--sega--PVcVSGEIknLdadaKrGFHVHEFGDNTN--------GCTSAGPHYNPfkK-nH Debaryomyces_hansenii VnFE--Qs--sesd--PttITwEISGndanalrGFHVHtFGDNTN--------GCTSAGPHFNPftK-EH Emericella_nidulans VtFE--Qa--dens--nttVSwnITGndpnaErGFHIHQFGDNTN--------GCTSAGPHFNPfgK-tH Eremothecium_gossypii VhFE--QE--adaa--vttISwnITGfepntEHGFHIHEFGDvTN--------GCTSsGsHFNPfkK-tH Gibberella_zeae VvFE--QE--sesa--PttITwDITGndpnaKrGFHIHtFGDNTN--------GCTSAGPHFNPhNK-tH Kluyveromyces_lactis VrFE--QE--sedq--qtkISwEITGndanalrGFHIHtFGDNTN--------GCTSAGPHFNPfNK-nH Neurospora_crassa ViFE--QE--sesa--PttITyDISGndpnaKrGFHIHtFGDNTN--------GCTSAGPHFNPhgt-tH Schizosaccharomyces_pombe VtFE--Qv--dqns--qVsVivDLvGndanaKrGFHIHQFGDNTN--------GCTSAGPHFNPegK-tH Yarrowia_lipolytica VtFE--QD--sesg--PVtVTyDIkGndpnaErGFHVHEFGDNTN--------GCTSAGPHFNPfkK-nH ================================================================================================ PHOTOBACTERIUM_LEIOGNATHI Iels--Qn----ky--gVvfipELadLtp-GmHGFHIHQnGscaSsekdgkvvlggaAGgHYDPeHtnKH Vibrio_splendidus Vmis--ss----ey--gavfTpELkdLpv-GtHGFHVHanGscdSitkdgkiilggaAGgHYDPektgKH ================================================================================================ Consensus IxFExxQExxxxxxxxPVxLSGeISGLxexGEHGFHVHQFGDNTSxxxxxxxxGCTSAGPHFNPxNKxEH 150 160 170 180 190 200 210 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus GgPEDEDRHVGDLGNIxANxNGVAEiNIeDnLISLsGxNSIIGRSMVVHEkxDDLGRGGNDESxKTGNAG ================================================================================================ BOVINE GGPKDEERHVGDLGNVtADkNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStKTGNAG HUMAN GGPKDEERHVGDLGNVtADkDGVADVSIEDSVISLSGdHcIIGRTLVVHEKaDDLGKGGNEEStKTGNAG XENLA GaPgDtDRHVGDLGNVtAe-gGVAQfkItDSLISLkGpNSIIGRTaVVHEKaDDLGKGGNDESlKTGNAG 1CB4A_Bovine GGPKDDERHVGDLGNVtADkNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStKTGNAG 1E9OA_Bovine GGPKDEERHVGDLGNVtADsNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStKTGNAG 1E9OB_Bovine GGPKDDERHVGDLGNVtADkNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStsTGNAG 1E9PA_Bovine GGPsDEERHVGDLGNVtADsNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStKTGNAG 1E9PB_Bovine GGPsDDERHVGDLGNVtADkNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStsTGNAG 3SODO_Bovine GGPKDEERHVGDLGNVtADkNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStKTGNAG 1AZVA_Human GGPKDEERHVGDLGNVtADkDGVADVSIEDSVISLSGdHcIIGRTLVVHEKaDDLGKGGNEEStKTGNAG 1FUNA_Human GGPKDEERHVGDLGNVtADkDGVADVSIEDSVISLSGdHSIIGRTLVVHEKaDDLGKGGNEEStETGNAG 1L3NA_Human GGPKDEERHVGDLGNVtADkDGVADVSIEDSVISLSGdHSIIGRTLVVHEKaDDLGKGGNEEStKTGNAG 1N19A_Human GGPKDEERHVGDLGNVtADkDGVADVSIEDSVISLSGdHSIIGRTLVVHEKaDDLGKGGNEEStKTGNAG 1PTZA_Human GGPKDEERHVGDLGNVtADkDGVADVSIEDSVISLSGdHSIIGRTLVVHEKaDDLGKGGNEEStKTGNAG Apis_mellifera GGPDsDiRHVGDLGNIeADaSGVAnVNItDktIqLqGpHSVIGRTLVVHadpDDLGKGGvElSktTGNAG Canis_lupus GGPKDQERHVGDLGNVtAgkDGVAiVSIEDSLIaLSGdySIIGRTMVVHEKrDDLGKGdNEEStQTGNAG Capra_hircus GGPKDEERHVGDLGNVkADkNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStKTGNAG Cavia_porcellus GGPQDEERHVGDLGNVtAgaDGVAnVSIEDSLISLSGaNSIIGRTMVVHEKpDDLGKGGNEEStKTGNAG Cebus_apella GGPEDEERHVGDLGNVtAgkDGVAKVSIEDSVISLSGdHSIIGRTLVVHEKaDDLGKGGNEEStKTGNAG Cervus_elaphus GGPKDEERHVGDLGNVtADkNGVAKVDIvDSLISLSGeHSIIGRTMVVHEKpDDLGRGGNEEStKTGNAr Chelonia_mydas GGPQDnERHVGDLGNViANkeGVAEVcIKDSLISLTGsqSIIGRTMVVHEKeDDLGKGGNDESlKTGNAG Danio_rerio GGPtDsvRHVGDLGNVtADaSGVAKIeIEDaMLTLSGqHSIIGRTMVIHEKeDDLGKGGNEESlKTGNAG Equus_caballus GGPKDEERHVGDLGNVtADeNGkADVDMKDSVISLSGkHSIIGRTMVVHEKqDDLGKGGNEEStKTGNAG Gallus_gallus GGPKDaDRHVGDLGNVtA-kgGVAEVeIEDSVISLTGpHcIIGRTMVVHaKsDDLGRGGDNESklTGNAG Hylobates_lar GGPKDEERHVGDLGNVtADkDGVAKVSIEDSVISLSGdHSIIGRTLVVHEKaDDLGKGGNEEStKTGNAG Macaca_mulatta GGPKDEERHVGDLGNVtAgkDGVAKVSfEDSVISLSGdHSIIGRTLVVHEKaDDLGKGGNEESkKTGNAG Mus_musculus GGPaDEERHVGDLGNVtAgkDGVAnVSIEDrVISLSGeHSIIGRTMVVHEKqDDLGKGGNEEStKTGNAG Oncorhynchus_mykiss GGPtDavRHVGDLGNVtAgaDnVAKINIQDkMLTLTGpDSIIGRTMVIHEKaDDLGKGGNEESlKTGNAG Oryctolagus_cuniculus GGPKDEERHVGDLGNVtAgsNGVADVlIEDSVISLSGdmSVIGRTLVVHEKeDDLGKGGNDEStKTGNAG Ovis_aries GGPKDEERHVGDLGNVkADkNGVAiVDIvDpLISLSGeySIIGRTMVVHEKpDDLGRGGNEEStKTGNAG Pongo_pygmaeus GGPKDEERHVGDLGNVtADkDGVAsVSIEDSVISLSGdHcIIGRTLVVHEKaDDLGKGGNEEStKTGNAG Rattus_norvegicus GGPaDEERHVGDLGNVaAgkDGVAnVSIEDrVISLSGeHSIIGRTMVVHEKqDDLGKGGNEEStKTGNAG Sus_scrofa GGPKDQERHVGDLGNVtAgkDGVAtVyIEDSVIaLSGdHSIIGRTMVVHEKpDDLGRGGNEEStKTGNAG Tetraodon_nigroviridis aGPnDENRHVGDLGNVtAeaDqIAKIDItDSVISLhGkfSIIGRTMVIHEKaDDLGKGGNEESlKTGNAG Xenopus_tropicalis GaPEDavRHVGDLGNVtA-kDGVAEfkLtDSLISLkGnHSIIGRcaVVHEKeDDLGKGGNDESlKTGNAG ================================================================================================ SCHISTOSOMA_MANSONI GaPEDsiRHVGDLGNVvAgaDGnAvyNatDkLISLNGsHSIIGRSMVIHEneDDLGRGGHElSkvTGNAG Schistosoma_japonicum GaPnDsiRHVGDLGNVvAtdDGkgvyDatDkLISLSGpHSIIGRTMVIHEneDDLGRGGHDlSkvTGNAG ================================================================================================ YEAST GaPtDEvRHVGDMGNVktDeNGVAKgSfKDSLIkLiGptSVVGRSVVIHagqDDLGKGdtEESlKTGNAG 1B4TA_Yeast GaPtDEvRHVGDMGNVktDeNGVAKgSfKDSLIkLiGptSVVGRSVVIHagqDDLGKGdtEESlKTGNAG 1F18A_Yeast GaPtDEvRHVGDMrNVktDeNGVAKgSfKDSLIkLiGptSVVGRSVVIHagqDDLGKGdtEESlKTGNAG 1F1AA_Yeast GaPtDEvRHVGDMGNVktDeNGVAKgSfKDSLIkLiGptSVVGRSVVIHagqDDLGKGdtEESlKTGNAG 1F1DA_Yeast GaPtDEvRHVGDMGNVktDeNGVAKgSfKDSLIkLiGptSVVGRSVVIHagqDDLGKGdtEESlKTGNAG 1JK9C_Yeast GaPtDEvRHVGDMGNVktDeNGVAKgSfKDSLIkLiGptSVVGRSVVIHagqDDLGKGdtEESlKTGNAG Aspergillus_flavus GaPEDENRHVGDLGNfktDaeGnAvgSkQDkLIkLiGaeSVLGRTLVIHagtDDLGRseHpESkKTGNAG Aspergillus_fumigatus GaPEDsERHVGDLGNfetDaeGnAvgSkQDkLIkLiGaeSVLGRTLVVHagtDDLGRGGNEESkKTGNAG Candida_albicans GaPEDDERHVGDLGNIstDgNGVAKgtkQDlLIkLiGkDSILGRTIVVHagtDDyGKGGfEDSktTGHAG Candida_glabrata GaPQDENRHVGDLGNIktDaqGVAKgvItDSLVkLiGptSVVGRSVVVHagtDDLGKGGNEESlKTGNAG Cryptococcus_neoformans GaPtDsERHVGDLGNVqtNgcGVAQVDIsDkIISLfGpHSIIGRSMVVHagtDDLGKGGNEESlKTGNAG Debaryomyces_hansenii GaPEDDNRHVGDLGNVttDtSGVAKgSkQDlfVkLiGqNSILGRTVVIHagtDDLGKGGNaESkKTGNAG Emericella_nidulans GaPEDEvRHVGDLGNfktDaeGnsKgSktDkLIkLiGaeSVLGRTLVVHagtDDLGRGdSEESkKTGNAG Eremothecium_gossypii GsPEDENRHVGDMGNVlADaNGVAvgSaKDpLIkIfGptSILGRTVVVHagkDDLGRGGNEESlKTGNAG Gibberella_zeae GaPsDEtRHVGDLGNVetDgqGnAKgSVtDSLIkLiGpHSVIGRTVVIHagtDDLGKGdgEESlKTGNAG Kluyveromyces_lactis GaPEDEERHVGDLGNIptDaqGIsKgSLtDkhIkLlGplSIVGRTVVVHagqDDLGKGGDaESlKTGNAG Neurospora_crassa GdrtaEvRHVGDLGNIetDaqGnAKgtVtDNLVkLiGpeSVIGRTVVVHagtDDLGKGGNEESlKTGNAG Schizosaccharomyces_pombe GdrtaavRHVGDLGNLesDaqGniKttfsDSVISLfGaNSIIGRTIVIHageDDLGKGtSEESlKTGNAG Yarrowia_lipolytica GGPtDsERHVGDLGNVktDseGVAKgvLKDSLLkLTGdNSIVGRTVVIHggeDDLGKGGHaDSlKTGNAG ================================================================================================ PHOTOBACTERIUM_LEIOGNATHI GfPwtDDnHkGDLpaLfvSaNGLAtnpVlaprL-tlk--eLkGhaIMIHaggDNhsdm----pkalGggG Vibrio_splendidus GfPwtDDnHLGDLppLyvNaHGVADqpVmaprV-tld--dVkGRaLMIHaggDNhsdh----paKlGggG ================================================================================================ Consensus GgPEDEDRHVGDLGNIxANxNGVAEiNIeDnLISLsGxNSIIGRSMVVHEkxDDLGRGGNDESxKTGNAG 220 230 240 250 260 270 280 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xRLACGVIGIAkxxxx ========================================== BOVINE sRLACGVIGIAK---- HUMAN sRLACGVIGIAQ---- XENLA gRLACGVIGysp---- 1CB4A_Bovine sRLACGVIGIAK---- 1E9OA_Bovine sRLACGVIGIAK---- 1E9OB_Bovine sRLACGVIGIAK---- 1E9PA_Bovine sRLACGVIGIAs---- 1E9PB_Bovine sRLACGVIGIAs---- 3SODO_Bovine sRLACGVIGIAK---- 1AZVA_Human sRLACGVIGIAQ---- 1FUNA_Human sRLACGVIGIAQ---- 1L3NA_Human sRLACGVIGIAQ---- 1N19A_Human sRLACGVIGIAQ---- 1PTZA_Human sRLACGVIGIAQ---- Apis_mellifera aRLACGVIGItKv--- Canis_lupus sRLACGVIGIAQ---- Capra_hircus scLACGVIGIAp---- Cavia_porcellus sRLACGVIGIAQ---- Cebus_apella sRLACGVIGIAQ---- Cervus_elaphus nRLACGVIGIAQ---- Chelonia_mydas sRLACGVVGIAKl--- Danio_rerio gRLACGVIGItQ---- Equus_caballus sRLACGVIGIAp---- Gallus_gallus pRLACGVIGIAKc--- Hylobates_lar sRLACGVIGIAQ---- Macaca_mulatta gRLACGVIGIAQ---- Mus_musculus sRLACGVIGIAQ---- Oncorhynchus_mykiss gRqACGVIGIAQ---- Oryctolagus_cuniculus sRLACGVIGIsp---- Ovis_aries gRLACGVIGIAp---- Pongo_pygmaeus sRLACGVIGIAQ---- Rattus_norvegicus sRLACGVIGIAQ---- Sus_scrofa sRLACGVIGItQ---- Tetraodon_nigroviridis gRLACGVIGItQ---- Xenopus_tropicalis gRLACGVIGLcQ---- ========================================== SCHISTOSOMA_MANSONI gRLACGVVGLAae--- Schistosoma_japonicum gRVACGVIGLAad--- ========================================== YEAST pRpACGVIGLtn---- 1B4TA_Yeast pRpACGVIGLtn---- 1F18A_Yeast pRpACGVIGLtn---- 1F1AA_Yeast pRpACGVIGLtn---- 1F1DA_Yeast pRpACGVIGLtn---- 1JK9C_Yeast pRpACGVIGLtn---- Aspergillus_flavus aRpACGVIGIAa---- Aspergillus_fumigatus aRpACGVIGIAa---- Candida_albicans aRpACGVIGLtQ---- Candida_glabrata pRpACGVIGLtn---- Cryptococcus_neoformans aRLACGVIGIst---- Debaryomyces_hansenii aRpACGVIGLsEkpns Emericella_nidulans aRpACGVIGIAa---- Eremothecium_gossypii pRpACGVIGIAn---- Gibberella_zeae pRpACGMciLlyfpmv Kluyveromyces_lactis aRhACGVIGIsn---- Neurospora_crassa pRpACGVIGIsQ---- Schizosaccharomyces_pombe aRnACGVIGIAv---- Yarrowia_lipolytica pRpACGVIGLta---- ========================================== PHOTOBACTERIUM_LEIOGNATHI aRVACGVIq------- Vibrio_splendidus aRIvCGVIk------- ========================================== Consensus xRLACGVIGIAkxxxx