10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxqxxKpiLYsYFRSSCswRVRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================ HUMAN ---QagKPILYSYFRSSCSWRVR---------------------------------------------------- Bos_taurus --aEssKPILYSYFRSSCSWRVR---------------------------------------------------- Canis_lupus t--EsgKPILYSYFRSSCSWRVRideeteaqklikllaqgrtaskcdeicsfweaglhwkaicrdpppprsplvf Danio_rerio tvaRliKPVLYgYYRSSCSWRVR---------------------------------------------------- Gallus_gallus ---aseKPILYSYFRSSCSWRVR---------------------------------------------------- Mus_musculus ---QagKPILYSYFRSSCSWRVR---------------------------------------------------- Pan_troglodytes ---QagKPILYSYFRSSCSWRVR---------------------------------------------------- Xenopus_laevis --aalgKPLLYgYFRSSCTWRVR---------------------------------------------------- ================================================================================================ ARABIDOPSIS_THALIANA tbsgzeKlkLYSYWRSSCahRVR---------------------------------------------------- ================================================================================================ Consensus xxxqxxKpiLYsYFRSSCswRVRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 80 90 100 110 120 130 140 150 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxIalalKgIdYExvpiNLiKdgGqQfseEFqalnpmkqVPaLkidgItIxqSlAIIeYLEetrPxPrLlPqDpq ================================================================================================ HUMAN --IALALKGIDYKtVPINLIKDGGQQFSKDFQALNPMKQVPtLKIDGITIhQSLAIIEYLEETRPtPRLLPQDPK Bos_taurus --IALALKnIDYEtVaINLtKDGGQQFSgEFQALNPMKQVPALKIDGITIgQSLAIIEYLEETRPtPRLLPwDPK Canis_lupus agItLALKnIDYEtIPtNLIKDGGQQFSKEFQALNPMKQVPvLKIDGITIgQSLAIIEYLEETRPtPRLLPQDPK Danio_rerio --IAfALKGIEYEqkPINLIKDGGQQlTDQFKAINPMQQVPAVsIDGITLsQSLAIIQYIEETRPePRLLPaDPm Gallus_gallus --IALALKGIaYDqVPVNLVKDGGQQFSaEFKAVNPMKQVPALKIDGITItQSLAIIQYLEDTRPnPRLLPQDPK Mus_musculus --IALALKGIDYEiVPINLIKDGGQQFTEEFQtLNPMKQVPALKIDGITIvQSLAIMEYLEETRPiPRLLPQDPQ Pan_troglodytes --IALALKGIDYEtVPINLIKDGGQQFSKDFQALNPMKQVPALKIDGITIhQSLAIIEYLEETRPtPRLLPQDPK Xenopus_laevis --IALAfKGIEYDqqaINLVKDGGlQlSDEYKqVNPMQQVPALhIDGVTLsQSLAIIEYLEETRPnPpLfPREPK ================================================================================================ ARABIDOPSIS_THALIANA --IALALKGLDYEyIPVNLLK--GdQFdsDFKkINPMgtVPALvdgdVvIndSfAIImYLDEkyPePpLLPRDlh ================================================================================================ Consensus xxIalalKgIdYExvpiNLiKdgGqQfseEFqalnpmkqVPaLkidgItIxqSlAIIeYLEetrPxPrLlPqDpq 160 170 180 190 200 210 220 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus KRAxvrmisNlIasGIQPlqnlsvlkqvgeexqlxwaqxxxxxxISxGFxALEqILqntaGkycvGDEvtmadlc ================================================================================================ HUMAN KRAsVRMISDLIAgGIQPLQNLSVLKQVGEEmQLtWAQ----naITcGFnALEQILQSTAGiYCVGDEVTMADLC Bos_taurus KRAqVRMVSDLIASGIQPLQNLSVLKQVGQEnQLtWAQ----qaITsGFnALEQILQSTAGRYCVGDEavpcgpr Canis_lupus KRAyVhMISNLIvSGIQPLQNLSVLKQLrQEnnLpWAQ----kaISsGFqALEQILQgTAGKYCVGDEVTMADLC Danio_rerio QRAhVRIIcDIIASGIQPLQNLyVLQKIGED-KVqWAQ----hfINrGFqALEpVLKeTAGKYCVGDEISMADIC Gallus_gallus KRAqVRMISDhIASGIQPLQNLSVLnKVGEr-KMeWAQ----qcITsGFqALEQILQHTAGRYCVGDEVSMADLC Mus_musculus KRAiVRMISDLIASGIQPLQNLSVLKQVGQEnQMqWAQ----kvITsGFnALEKILQSTAGKYCVGDEVSMADVC Pan_troglodytes KRAsVRMISDLIAgGIQPLQNLSVLKQVrEEmQLtWAQ----naITsGFnALEQILQSTAGiYCVGDEVTMADLC Xenopus_laevis KRAqVRMISDqIASGIQPLQNLcVLQKIGEtkQ-eWAK----hfITrGFqALEKMLQiTsGsYCVGDEVTVADLC ================================================================================================ ARABIDOPSIS_THALIANA KRAvnyqamSIVlSGIQPhQNLaVIRyIeEKinVeektawvnnaITkGFtALEKLLvNcAGKhatGDEIyLADLf ================================================================================================ Consensus KRAxvrmisNlIasGIQPlqnlsvlkqvgeexqlxwaqxxxxxxISxGFxALEqILqntaGkycvGDEvtmadlc 230 240 250 260 270 280 290 300 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus LvpqvanaexRFkVNLspyPtIskinKxllxLeaFqvshPxRQPDtPxelrx ========================================================================= HUMAN LVPQVANAE-RFKVDLTPYPTISsINKrLLvLEAFQVSHPcRQPDTPtELRa Bos_taurus L-rwMflcp-RFKVDLTPYPTISRINKsLLaLEAFhVSHPcRQPDTPpELRa Canis_lupus LVPQVANAE-RFEVDLTPYPaISRINKtLLaLEAFQVSHPcRQPDTPpELRa Danio_rerio LVPQVyNAD-RFKVDMTqYPTIrRLNQtLVeIEAFKaSHPsRQPDTPdDLRl Gallus_gallus LVPQaANAE-RYgVSLdPYPTITRINKaLLeLEAFKVSHPsRQPDTPaELRs Mus_musculus LVPQVANAE-RFKVDLSPYPTIShINKeLLaLEvFQVSHPrRQPDTPaELRt Pan_troglodytes LVPQVANAE-RFKVDLTPYPTISsINKrLLvLEAFQVSHPcRQPDTPtELRa Xenopus_laevis LVPQVANAv-RFKVDLSPYPTIvRINEsLLqMEAFQVSHPsRQPDTPeELRa ========================================================================= ARABIDOPSIS_THALIANA LaPQIhgAinRFQINMePYPTLaKcyEsyneLpAFQnalPeKQPDaPssti- ========================================================================= Consensus LvpqvanaexRFkVNLspyPtIskinKxllxLeaFqvshPxRQPDtPxelrx