Poly(A) polymerase

                                     360       370       380       390       400       410       420
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     iastvihkfflifskwewpnpvvikqpddxxnlnlpvwnpkinpsdrfhlmpvitpaypqqnstynitvs
====================================================================================================
YEAST                         acSaVIlnrFfIilsewnwpqpVIlKPiEdgpLqVrVWNPKIyaqDRsHrMPVITPAYPsmcaThNITeS
Candida_glabrata              acSaVIlnrFfkilsewkwpqpVIlKPiEdgpLqVrVWNPKIyaqDRsHrMPVITPAYPsmcaThNITeS
Eremothecium_gossypii         acSaVIvarFfhiltrwswpqpVLlKPiEdgpLqVrVWNPKIyaNDRlHkMPVITPAYPsmcSThNIceS
Kluyveromyces_lactis          acSaVIiskFfqilsrwkwpqpVLlKPiEdgpLqVrVWNPKIyaqDRsHkMPVITPAYPsmcaThNISeS
====================================================================================================
BOVINE                        IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Apis_mellifera                VAaTLIeKFFLVFSQWKWPqPVLLKQPDNv-NLgfPVWDPRVNiSDRYHLMPIITPAYPQQNSTFNVSVS
Canis_lupus                   IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Danio_rerio                   VAaTLVHKFFLVFSKWEWPNPVLLKQPEDc-NLNLPVWDPRVtPSDRYHLMPIITPAYPQQNSTYNVSaS
Drosophila_melanogaster       aAaTLVHKFFLVFSRWKWPNPVLLKhPDNv-NLrfqVWDPRVNaSDRYHLMPIITPAYPQQNSTFNVSeS
Gallus_gallus                 IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Homo_sapiens                  IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Mus_musculus                  IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Rattus_norvegicus             IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Strongylocentrotus_purpuratus aASTLVNKFFLVFTKWaWPqPVLLKpPNtsteLgfaeWDPRVNvSDRFHLMPIITPAYPQQNSTYNVSqS
Xenopus_laevis                IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Xenopus_tropicalis            IASTLVHKFFLVFSKWEWPNPVLLKQPEDs-NLNLPVWDPRVNPaDRcHLMPIITPAYPQQNSTYNVSIS
====================================================================================================
Consensus                     iastvihkfflifskwewpnpvvikqpddxxnlnlpvwnpkinpsdrfhlmpvitpaypqqnstynitvs

Page 6 of 14