Poly(A) polymerase

                                      10        20        30        40        50        60        70
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
====================================================================================================
YEAST                         ----------------------------------------------------------------------
Candida_glabrata              ----------------------------------------------------------------------
Eremothecium_gossypii         ----------------------------------------------------------------------
Kluyveromyces_lactis          ----------------------------------------------------------------------
====================================================================================================
BOVINE                        ----------------------------------------------------------------------
Apis_mellifera                -wssq-----------------------------------------------------------------
Canis_lupus                   sgrkaqaeageehrg-----yptldntvaemrvvaeemekg-vtsdgfwrcnsqela-mgwlqlvsdcr-
Danio_rerio                   ----------------------------------------------------------------------
Drosophila_melanogaster       ----wn----------------------------------------------------------------
Gallus_gallus                 agfsqntgsggikrercaclypaakreas-----lsfrnagevsptaperaifpryagvgdsggvspavp
Homo_sapiens                  -gtsnspghssfsa-------pstkkikt-----trkqnia-----------------------------
Mus_musculus                  ----------------------------------------------------------------------
Rattus_norvegicus             ----------------------------------------------------------------------
Strongylocentrotus_purpuratus ----------------------------------------------------------------------
Xenopus_laevis                ----------------------------------------------------------------------
Xenopus_tropicalis            ----------------------------------------------------------------------
====================================================================================================
Consensus                     xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx

                                      80        90       100       110       120       130       140
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     xxxxxxxxxxxxxxpxstqxxxxxxsxxsxxxxqqxygittpislaxpkexdxxxtqelleslkpygvfe
====================================================================================================
YEAST                         --------------------------------ssQkvfgiTgpvstvgataaenklnDsLiqelkkegsf
Candida_glabrata              --------------------------------nyQkvygiTgpvsiagptaaenklnDeLiqelkkensf
Eremothecium_gossypii         --------------------------------sQQkvygvTgpiskegptaaenklnDeLiqelkkegtf
Kluyveromyces_lactis          --------------------------------sQKkifgvTgpistegptaaenalnDsLiqqlkkegsf
====================================================================================================
BOVINE                        ------------pfPvTTQ-----gSqqT-qppQKhYGITSPISLAaPKEtDcllTQKLVETLKPFGVFE
Apis_mellifera                ------------gnnsNSn-----nSske-eknlRtlGMTSaISVAePKpsDftrTnELkEaLKPYnVFE
Canis_lupus                   n-plavilsnfvcsPvTTQ-----gSqqT-qppQKhYGITSPISLAaPKEtDcllTQKLIETLKPFGVFE
Danio_rerio                   ------------pfPiTSQ------vqta-qptpKhYGITSPISLApPKEaDlvlTRKLtETLRPFGVFE
Drosophila_melanogaster       ------------sePthrQhhqhngNstSggppaKqlGMTSaISLAePRpeDlqrTdELrgSLEPYnVFE
Gallus_gallus                 aqplslrnspg-plPvTTQ-----gS-qT-qqlQKhYGITSPISLAaPKEfDcmlTQKLIETLKPYGVFE
Homo_sapiens                  ------------pfPvTTQ-----gSqqT-qppQKhYGITSPISLAaPKEtDcvlTQKLIETLKPFGVFE
Mus_musculus                  ------------pfPvTTQ-----gSqqT-qppQRhYGITSPISLAaPKEtDcllTQKLIETLKPFGVFE
Rattus_norvegicus             ------------pfPvTTQ-----gSqqT-qppQRhYGITSPISLAaPKEtDcllTQKLIETLKPFGVFE
Strongylocentrotus_purpuratus ----------------STa-----sSesS---tKKtYGITSaISLvgPRpeDnrqTKELVEaLKPhGVFE
Xenopus_laevis                ------------pfPlaSQ-----gSqqS----QKtYGITSPISLAtPKDtDctlTQKLIETLKPYGVFE
Xenopus_tropicalis            --------------reTlg-----sSvla-gqppKhYGITSPISLAgPKDtDhiyTQKLtEaMRPFGVFE
====================================================================================================
Consensus                     xxxxxxxxxxxxxxpxstqxxxxxxsxxsxxxxqqxygittpislaxpkexdxxxtqelleslkpygvfe

                                     150       160       170       180       190       200       210
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     deeqlxxkivivgkinxllkewireisexknlpxnvmexvggkiftfgsyrlgvhtkgadidalcvaprn
====================================================================================================
YEAST                         EtEQetanrVqVlKIlqeLaQrfvyevskKknmsDgMardaGgkiftygsyrlgvhgpgsdidtlVvvpk
Candida_glabrata              EsEQetanrVkVlKtlqeLtEkfvyevskKknmsDgMardaGgkiftygsyrlgvhgpgsdidtlVvvpk
Eremothecium_gossypii         EsEEetaKrIkVlEelqaLaQefvfkvsrKrnmsegMardaGgkiftfgsyrlgvhgpgsdidtlVvvpk
Kluyveromyces_lactis          EtEEetgKrVaVlEIfqkLtQefvyqvskKknmsDgMardaGgkvftfgsyrlgvhgpgsdidtlIvvpk
====================================================================================================
BOVINE                        EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH
Apis_mellifera                sEEELnhRMeILsKLNaLVKQWIRDtSvaRNMPpNVaEqVGGKIYTFGSYRLGVHhKGADIDALCVvPRH
Canis_lupus                   EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH
Danio_rerio                   EElELqrRILVLGKLNtLVKfWIREVSEaKNIPaSVIDsVGGKIFTFGSYRLGVHTKGADIDALCVAPRH
Drosophila_melanogaster       sQDELnhRMeILaKLNtLVKQWVKEISvsKNMPeSaaEkLGGKIYTFGSYRLGVHhKGADIDALCVAPRN
Gallus_gallus                 EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH
Homo_sapiens                  EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH
Mus_musculus                  EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH
Rattus_norvegicus             EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH
Strongylocentrotus_purpuratus NEEELnhRLVVLGKLDqIVKDWIRlVaEeKNIPpNIaDtVGGKIYTFGSYRLGVHTKGADIDtLCVAPlH
Xenopus_laevis                EEDELqhRILILGKLNnLVKEWIREISElKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH
Xenopus_tropicalis            DDaELshRMVVLGKLNnLVKEWIgELgEqKSLPpSIIsaVGGKIFTFGSYRLGVHTKGADIDsLCVAPRH
====================================================================================================
Consensus                     deeqlxxkivivgkinxllkewireisexknlpxnvmexvggkiftfgsyrlgvhtkgadidalcvaprn

                                     220       230       240       250       260       270       280
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     vdrseffstffdelkkeekvkdlraveeafvpviklxfdgieidilfarlalqxipenldlrddsllknl
====================================================================================================
YEAST                         hvtrEdFfTvFDsLlRErKelDeiApvpdafvpIikikfsgisidLicarldQpqvplsltlsDknLlrn
Candida_glabrata              hvtrEdFfTvFDaLlRErEelDeiApvpdafvpIiklkfsgisidLicakldiaqvKpsltlDDkaLlrn
Eremothecium_gossypii         hvtrDdFfTvFDELlRarpelDeiApvpeafvpIikikysgisidLicarldipqvplnltlsDknLlrn
Kluyveromyces_lactis          hvsrEdFfTvFDaLlRErpelEeiAsvpdafvpIikikfngisidLifakldlpqvpisltlsDknLlrn
====================================================================================================
BOVINE                        VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL
Apis_mellifera                IyRSDYFTSFFElLKmQEEVtDLRAVEEAFVPVIKMnFDGIEIDMLFAKLALKeIPDSMDLRDDmLLKNL
Canis_lupus                   VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL
Danio_rerio                   VERTDFFSSFYEKLKEQEEVKDLRAVEEAFVPVIKLaFDGIEIDILFARLALQtIPENLDLRDDgLLKNL
Drosophila_melanogaster       IERTDYFqSFFEvLKKQpEVtEcRsVEEAFVPVIKMnFDGIEIDLLFARLsLKeIPDDfDLRDDNLLRNL
Gallus_gallus                 VERSDFFTSFYEKLKQQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL
Homo_sapiens                  VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL
Mus_musculus                  VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL
Rattus_norvegicus             VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL
Strongylocentrotus_purpuratus VERSDFFkSFYDiVKalpEtKDcRAVEEAFVPVIKLvFDGIEMDILFARLALRvVPENLDLtDDSLLKNL
Xenopus_laevis                VDRSDFFSSFYEKLKQQEEVKDLRsVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL
Xenopus_tropicalis            VERSDFFqSFsEKLKQQDgIKNLRAVEDAFVPVIKfeFmntEIDLVFARLpLQcIPDNLDLRDDSrLRNL
====================================================================================================
Consensus                     vdrseffstffdelkkeekvkdlraveeafvpviklxfdgieidilfarlalqxipenldlrddsllknl

                                     290       300       310       320       330       340       350
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     dikcirslngcrvtddiihllpniesfrltlraiklwakqhxiysniigflggvswammlartcqlypna
====================================================================================================
YEAST                         ldEkdlralngtrvtDeIleLvpkpNvfrialraiklwaQrravyanIfgfpGgvawaMLvaricqlypn
Candida_glabrata              ldEkdlralngtrvtDeIleLvpkpSvfrialraikiwaQrraiyanVfgfpGgvawaMLvaricqlypn
Eremothecium_gossypii         ldEkdlralngtrvtDeIleLvpkpTafkialraiklwaQrravyanVfgfpGgvawaMLvaricqlypn
Kluyveromyces_lactis          vdEkdlralngtrvtDeIleLvpnKTsfkialraikiwaKrravyanVfgfpGgvawaMfvvricqlypn
====================================================================================================
BOVINE                        DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA
Apis_mellifera                DqKCVRSLNGCRVTDEILrLVPNIENFRLaLRAIKLWAKRHgIYSNVLGYLGGVSWAMLVARTCQLYPNA
Canis_lupus                   DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA
Danio_rerio                   DIRCIRSLNGCRVTDEILHLVPNIENFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA
Drosophila_melanogaster       DhRsVRSLNGCRVTDEILaLVPNIENFRLaLRtIKLWAKKHgIYSNsLGYfGGVTWAMLVARTCQLYPNA
Gallus_gallus                 DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA
Homo_sapiens                  DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA
Mus_musculus                  DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA
Rattus_norvegicus             DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA
Strongylocentrotus_purpuratus DpKCVRSLNGCRVTDEILNVVPSkENFRLTLRtIKLWAKKkgVYSNaLGFLGGVSWAMLVARTCQLYPNA
Xenopus_laevis                DIRCIRSLNGCRVTDEILHLVPNIDSFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA
Xenopus_tropicalis            DIRCIRSLNGCRVTDEILHLVPNkENFRLTLRAIKLWAKRrgIYSNMLGFLGGVSWAMLVARTCQLYPNA
====================================================================================================
Consensus                     dikcirslngcrvtddiihllpniesfrltlraiklwakqhxiysniigflggvswammlartcqlypna

                                     360       370       380       390       400       410       420
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     iastvihkfflifskwewpnpvvikqpddxxnlnlpvwnpkinpsdrfhlmpvitpaypqqnstynitvs
====================================================================================================
YEAST                         acSaVIlnrFfIilsewnwpqpVIlKPiEdgpLqVrVWNPKIyaqDRsHrMPVITPAYPsmcaThNITeS
Candida_glabrata              acSaVIlnrFfkilsewkwpqpVIlKPiEdgpLqVrVWNPKIyaqDRsHrMPVITPAYPsmcaThNITeS
Eremothecium_gossypii         acSaVIvarFfhiltrwswpqpVLlKPiEdgpLqVrVWNPKIyaNDRlHkMPVITPAYPsmcSThNIceS
Kluyveromyces_lactis          acSaVIiskFfqilsrwkwpqpVLlKPiEdgpLqVrVWNPKIyaqDRsHkMPVITPAYPsmcaThNISeS
====================================================================================================
BOVINE                        IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Apis_mellifera                VAaTLIeKFFLVFSQWKWPqPVLLKQPDNv-NLgfPVWDPRVNiSDRYHLMPIITPAYPQQNSTFNVSVS
Canis_lupus                   IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Danio_rerio                   VAaTLVHKFFLVFSKWEWPNPVLLKQPEDc-NLNLPVWDPRVtPSDRYHLMPIITPAYPQQNSTYNVSaS
Drosophila_melanogaster       aAaTLVHKFFLVFSRWKWPNPVLLKhPDNv-NLrfqVWDPRVNaSDRYHLMPIITPAYPQQNSTFNVSeS
Gallus_gallus                 IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Homo_sapiens                  IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Mus_musculus                  IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Rattus_norvegicus             IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Strongylocentrotus_purpuratus aASTLVNKFFLVFTKWaWPqPVLLKpPNtsteLgfaeWDPRVNvSDRFHLMPIITPAYPQQNSTYNVSqS
Xenopus_laevis                IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS
Xenopus_tropicalis            IASTLVHKFFLVFSKWEWPNPVLLKQPEDs-NLNLPVWDPRVNPaDRcHLMPIITPAYPQQNSTYNVSIS
====================================================================================================
Consensus                     iastvihkfflifskwewpnpvvikqpddxxnlnlpvwnpkinpsdrfhlmpvitpaypqqnstynitvs

                                     430       440       450       460       470       480       490
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     tkxvilqefqrgvaitneillnkaxwsklfeapNFFxRYKhYLvIMASaxxSDEExLKWvGLVESKVRLL
====================================================================================================
YEAST                         TKkVILQEFvRGVqITNDIfsNKksWanLFEknDFFfRYKfYLeItAytrgSDEQhLKWsGLVESKVRLL
Candida_glabrata              TKaVILKElnRGIqVTNDIfayKktWadLFtkhDFFfQYKyYLtItAatrgdDEEhLKWsGLVESKLRLL
Eremothecium_gossypii         TKkVILnElQRGVeVTtDIftNKktWgdLFQkhDFFyKYKfYLtVMAStkgSDEQhLKWsGLVESKLRLL
Kluyveromyces_lactis          TKkVILsElQRGVeVTqKIfsNElsWedLFKkhDFFfKYKfYLtVMvStkgSDEQhLKWsGfVESKLRLL
====================================================================================================
BOVINE                        TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL
Apis_mellifera                TRtIMqEaFEnGLsITeEIIMgKAtWdKLFEpPNFFgKYKHYIVLLArsl-TaEDqLEWcGLVESKIRhL
Canis_lupus                   TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL
Danio_rerio                   TRaIMVEEFKRGLAITDEILqNKAdWSKLFEAPNFFqKYKHYIVLLASAq-TEKQhLEWVGLVESKIRIL
Drosophila_melanogaster       TKkVILtEFnRGMnITDEIMLgRipWeRLFEAPSFFyRYRHFIVLLvNsq-TaDDhLEWcGLVESKVRLL
Gallus_gallus                 TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL
Homo_sapiens                  TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL
Mus_musculus                  TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL
Rattus_norvegicus             TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL
Strongylocentrotus_purpuratus TKtVIeQElQgGLAITqEIMqgKAtWeKLFEssNFFgKYKHYIVLIASAg-NEDDhLKWVGLVESKIRVL
Xenopus_laevis                TRaVMVEEFKQGLAITDEILLlKAeWSKLFDAPNFFqKYKHYILLLASAp-TEKQrLEWVGLVESKIRIL
Xenopus_tropicalis            TRsVMVEEFKQGLsVTDEILLgRcdWSKLFEpPNFFhKYKHYIVLtASAs-TEEhhLEWVGLVESKIRVL
====================================================================================================
Consensus                     tkxvilqefqrgvaitneillnkaxwsklfeapNFFxRYKhYLvIMASaxxSDEExLKWvGLVESKVRLL

                                     500       510       520       530       540       550       560
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     VgsLEknxfItIAHvnpKsFxpxxxxxxxxxxpkdnxekxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
====================================================================================================
YEAST                         VmkLEvlagIkIAHpftKpF-e--------s-------syccpteddyemiqdkygshktetalnalklv
Candida_glabrata              tlkLEtipgIkLAHpffKpF-e--------a-------aycytddqdaktilnnhgshitekalekftkv
Eremothecium_gossypii         VlkLEvlsgInLAHpytKpF-e--------s-------tyaykteeqykeifdnygthktedvlkkytev
Kluyveromyces_lactis          VqkLEvlpgInLAHpfiEpY-e--------s-------syiynnedeykeimnnygthktegvlkkftki
====================================================================================================
BOVINE                        VGSLEKNeFITLAHVNPQSF-P--------a-PKENpDK-------------------------------
Apis_mellifera                IGTLERNphITLAHVNPEaF-P----------PlE-pEp-------------------------------
Canis_lupus                   VGSLEKNeFITLAHVNPQSF-P--------a-PKENpDK-------------------------------
Danio_rerio                   VGNLEKNeFITLAHVNPQSF-P--------g-PKEgnDK-------------------------------
Drosophila_melanogaster       IGNLERNphIaLAHVNPKcF-efkkgzsann-sQNNsgn-------------------------------
Gallus_gallus                 VGNLEKNeFITLAHVNPQSF-P--------a-PKENpDK-------------------------------
Homo_sapiens                  VGSLEKNeFITLAHVNPQSF-P--------a-PKENpDK-------------------------------
Mus_musculus                  VGSLEKNeFITLAHVNPQSF-P--------a-PKESpDR-------------------------------
Rattus_norvegicus             VGSLEKNeFITLAHVNPQSF-P--------a-PKESpDR-------------------------------
Strongylocentrotus_purpuratus VGNLERNphIkLAHVyPKSisP--------stPlDgsEE-------------------------------
Xenopus_laevis                VGSLEKNeFITLAHVNPQSF-P--------a-PsENsEK-------------------------------
Xenopus_tropicalis            VGNLERNsFITLAHVNPQSF-P--------g-nRDHcKd-------------------------------
====================================================================================================
Consensus                     VgsLEknxfItIAHvnpKsFxpxxxxxxxxxxpkdnxekxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx

                                     570       580       590       600       610       620       630
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     xxxxxxxxxxxxxxxexxxexxxxxxxxxxxxxxxxfxTmwxIGLvFkkxensenvsvDItfdiQsFtDt
====================================================================================================
YEAST                         tdenkeeesikdapka---y----------------lsT-myIGLdFnienkkEkV--DIhipcteFvNl
Candida_glabrata              tdenkddedvkskkkv---h----------------itT-myVGLgvsvenkkEkI--DMhipcgeFfNl
Eremothecium_gossypii         tnenkddeslkgmekv---h----------------itT-myIGLniavdEkk-kI--DIhvpcQeFfNl
Kluyveromyces_lactis          tdankddeasknsnqv---h----------------iaT-mfIGLdinteESk-kI--DIhipcQeFfNl
====================================================================================================
BOVINE                        ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT
Apis_mellifera                ---------------E---r----------------hcSMWfIGLLFaK---SENLNVDLTYDIKSFvDS
Canis_lupus                   ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT
Danio_rerio                   ---------------E---E----------------FsTMWvIGIVFKKmEgSENLNVDLTFDIQSFTDT
Drosophila_melanogaster       ---------------E---DdlkqsqgnqsavtsapFcSMWfIGLeF---ErSENLNVDLTesIQNFTEh
Gallus_gallus                 ---------------E---E----------------YrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT
Homo_sapiens                  ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT
Mus_musculus                  ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT
Rattus_norvegicus             ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT
Strongylocentrotus_purpuratus ---------------EktdE----------------hsTLWfIGLeFQplgpatN--VNLTlDIQfFvNT
Xenopus_laevis                ---------------E---E----------------FrTMWvIGLVFKKmENSENLSVDLTYDIQSFTDT
Xenopus_tropicalis            ---------------n---E----------------YvSMWfLGIIFKKvENaESVNIDLThDIQSFTDT
====================================================================================================
Consensus                     xxxxxxxxxxxxxxxexxxexxxxxxxxxxxxxxxxfxTmwxIGLvFkkxensenvsvDItfdiQsFtDt

                                     640       650       660       670       680       690       700
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     vyrqaisxxkmxKxxmkLxaxhVKkrELhExVpsxllqrxkkknsxkglxxxxxxxxxkxxxlnnsslnl
====================================================================================================
YEAST                         crsfnedygd-hKvf-nLalrfVKgyDLpDeVfdeneKRpsKKSkrKnLdarh--etvKrsksD------
Candida_glabrata              crnfheSyqn-pEvy-sLviryLKsyELpDdVfgedeQRptKKlSkKrkeakydeeaaKrskae------
Eremothecium_gossypii         crsfq-eyed-tEtf-sLvikyVKlyDLpDhVydegeQRpvKaSkkRknekag--kkaKrpksSSvlaad
Kluyveromyces_lactis          crsl-pdyed-pEty-sLiikyVKvhDLpDeVyqegetRpvKsSkkRkpeksg--eksKrpksD------
====================================================================================================
BOVINE                        VYRQAIN-sKMfEvdMKIaAmHVKRKQLHQlLPShVLQK-KKKHStEGV---------KltpLNDSSLDL
Apis_mellifera                IlRQAeq-lsMlKegMwIevkHVKKRDLHtyVspsLLKR-ERK--vsG-------------tVHkNg-NI
Canis_lupus                   VYRQAIN-sKMfEvdMKIaAmHVKRKQLHQlLPNhVLQK-KKKHStEGV---------RltpLNDSSLDL
Danio_rerio                   VYRQAIT-sKMfEqdMKItAmHVKRKQLHQlLPevaIhRsKRKHSsdGV---------R--aMNDSNLDL
Drosophila_melanogaster       VmmhgVN-iKMlKegMtIdArHVKRKQLslyLdSdfLKR-ERK-SmEsh---------n--nfNN-TL-L
Gallus_gallus                 VYRQAIN-sKMfEmdMKIaArHVKRKQLHQlLPNhVLQK-KKKHStEGV---------RltaLNDSSLDL
Homo_sapiens                  VYRQAIN-sKMfEvdMKIaAmHVKRKQLHQlLPNhVLQK-KKKHStEGV---------KltaLNDSSLDL
Mus_musculus                  VYRQAIN-sKMfEldMKIaAmHVKRKQLHQlLPShVLQK-RKKHStEGV---------KltaLNDSSLDL
Rattus_norvegicus             VYRQAIN-sKMfEldMKIaAmHVKRKQLHQlLPShVLQK-RKKHStEGV---------KlaaLNDSSLDL
Strongylocentrotus_purpuratus VhRhsVT-iKLlQegMKIeAkHVKR--yeEqaPT--------gNaaE-------------ip----TIkV
Xenopus_laevis                VYRQAIN-sKMfEteMKIaAmHVKRKQLHQlLPShVLpK-KKKHSvEGV---------KlvsLNDSSIDL
Xenopus_tropicalis            VYRQAnN-inMlKkgMRIeAtHVKRKQLHhyLhaeVLQK-RKKqSvpdInrsasallsKrtsLDgNcLDs
====================================================================================================
Consensus                     vyrqaisxxkmxKxxmkLxaxhVKkrELhExVpsxllqrxkkknsxkglxxxxxxxxxkxxxlnnsslnl

                                     710       720       730       740       750       760       770
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     sinsessxsvxspsnxxkxxxxxssplxnsgxxsqgrsnxxxxxsxxasvxxxqxxdxvxxlpxxnxsxs
====================================================================================================
YEAST                         aaSgD-------niNgttaavdvN----------------------------------------------
Candida_glabrata              TISks-------avSeattvssa-----------------------------------------------
Eremothecium_gossypii         aeDSt-------maDgstvseepqpPLsNTtapStntgaelsvaaggASt--------------------
Kluyveromyces_lactis          psNgKSTtTtsgnTNssspvndaN-stpSSnvpansnTNaitedpmtATt--------------------
====================================================================================================
BOVINE                        SMDSDNSmSVpSPTSamK-----TSPLnSSG-sSQGRNSpapavTa-ASVtniQatE-V-sLPqiNsSeS
Apis_mellifera                a-gNgNSgSV-SP----------rNP----G-nTtnRkrlsdqnqd-ASIkkrKvnD-g-eqPsvthhge
Canis_lupus                   SMDSDNSmSVpSPTSamK-----TSPLnSSG-sSQGRNSpapavTa-ASVtnpQatE-V-sVPqvNsTeS
Danio_rerio                   SLDSDNSmSVpSPTgp-s-----aakIarap-spQGsTgtatntSelqgkteatgeN-t-hLasvDgTsS
Drosophila_melanogaster       anrkrlSteLaqsqDplp-----pgqqpSSG--NRGRdS------g-AkIqrlsd-----sLteeNsNaS
Gallus_gallus                 SMDSDNStSVpSPTSamK-----TSPLnSSG-sSQGRSSpapavTa-ASVtniQasE-V-tVPqtNsSeS
Homo_sapiens                  SMDSDNSmSVpSPTSatK-----TSPLnSSG-sSQGRNSpapavTa-ASVtniQatE-V-sVPqvNsSeS
Mus_musculus                  SMDSDNSmSVpSPTSamK-----TSPLnSSG-sSQGRNSpapavTa-ASVtsiQasE-V-sVPqaNsSeS
Rattus_norvegicus             SMDSDNSmSVpSPTSamK-----TSPLnSSG-sSQGRNSpapavTa-ASVtsiQasE-V-sVPqaNsSeS
Strongylocentrotus_purpuratus TapdEdT---qePS--iK-------PsgDda-qTfkRpSspppvSe-spskkvRtdNgV-tIP-----dT
Xenopus_laevis                SVDSDNSmSVpSPTNatR-----TSPLnSSG-lSQG-NSpatpvS--lSVtntQatD-V-mVPqnNsTeN
Xenopus_tropicalis            SrDTDTgtpcdSPTSchK-----SSrsdSpslpdaqRqSllektSt-gcsqkmadvh-VhaePaqglSip
====================================================================================================
Consensus                     sinsessxsvxspsnxxkxxxxxssplxnsgxxsqgrsnxxxxxsxxasvxxxqxxdxvxxlpxxnxsxs

                                     780       790       800       810       820       830       840
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     xxgxxxxxixqsxxexxxsxxxxpsxxxxxxxxrlxspxxkxxxxxxxsgsxxxxxxxxixxpixxxkxx
====================================================================================================
YEAST                         ----------------------------------------------------------------------
Candida_glabrata              ----------------------------------------------------------------------
Eremothecium_gossypii         ----------------------------------------------------------------------
Kluyveromyces_lactis          ----------------------------------------------------------------------
====================================================================================================
BOVINE                        sgGtssesIpQTatQpaiSsppkPTvsrvvsstRLvNPppRp------SGNaa----akIpnPIvgvKrt
Apis_mellifera                dgsl----VvQScgEdsnSgfsldeykqtlsaaK----degp------TGast----vaqegyVct----
Canis_lupus                   sgGtssesIpQTatQpaiSpppkPTvsrvvsstRLvNPppRp------SGNaa----tkIpnPIvgvKrt
Danio_rerio                   snasgkgaappqstsp-iqsekkPSe-----q----NPlpsp------clSae----paVkrPasalEne
Drosophila_melanogaster       s-------------DmgagtpttPT------taQLsaPsfKs------SGkng----seI--dVve-Qep
Gallus_gallus                 sgGssnesIpQTatQpaiSpppkPTisriassthLlNPspRi------SGNva----tktpsPVtavKrt
Homo_sapiens                  sgGtssesIpQTatQpaiSpppkPTvsrvvsstRLvNPppRssgnaatSGNaa----tkIptPIvgvKrt
Mus_musculus                  pgGpssesIpQTatQpaiSpppkPTvsrvvsstRLvNPspRp------SGNta----tkVpnPIvgvKrt
Rattus_norvegicus             pgGpssesIpQTatQpaiSpppkPTvsrvvsstRLvNPspRp------SGNaa----tkVpnPIvgvKrt
Strongylocentrotus_purpuratus kqGeddseVkETeeEe--------------detQtfk---Rp------Ss----------piPVl----e
Xenopus_laevis                sgGslnesIpETathpafSstprPlvtrvvssmRLvNqvqKp------vtNtv----tkMpsPVagvKrt
Xenopus_tropicalis            viGskpesaivvkgllppSgctiPTvvglnvipRLpSPpnfs------qGNttqnglinLspksaaaKra
====================================================================================================
Consensus                     xxgxxxxxixqsxxexxxsxxxxpsxxxxxxxxrlxspxxkxxxxxxxsgsxxxxxxxxixxpixxxkxx

                                     850       860       870       880       890       900       910
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     sxpxxxesxxxxkxxxxexxsxxxxxxxxxxxdxxexeexxxxxxxxxxxxxxxxxxxxxxxqkxxsxdl
====================================================================================================
YEAST                         ----------------------------------------------------------------------
Candida_glabrata              ----------------------------------------------------------------------
Eremothecium_gossypii         ----------------------------------------------------------------------
Kluyveromyces_lactis          ----------------------------------------------------------------------
====================================================================================================
BOVINE                        SsPhkeESpkktKtee-DetSedanclalsghDktEtKEqldtetsttqsetiqtatsllasQKtsStDL
Apis_mellifera                ----------------------------------------------------------------------
Canis_lupus                   SsPhkeESpkktKtee-DetSedanclalsghDktEtKEqldtetsttqsetihtaasllasQKtsStDL
Danio_rerio                   mt-kkaKvedlsapea-KssgetdghvapaivEvipsDgelktetelmvedtaekvp--l-aQKtsNaDL
Drosophila_melanogaster       TqPhnngN-----ass-nttTtevacs-------------------------------------------
Gallus_gallus                 SsPhkeDSpkkmKieeqDeiSettscidvnehErmEtKElletevn-vnsqmehlqttlqapQKtpStDL
Homo_sapiens                  SsPhkeESpkktKtee-DetSedanclalsghDktEaKEqldtetsttqsetiqtaasllasQKtsStDL
Mus_musculus                  SsPnkeESpkktKtee-DetSedanclalsghDktEtKEqvdletsavqsetvpasasllasQKtsStDL
Rattus_norvegicus             SsPhkeESpkktKtee-DetSedanclalsghDktEtKEqvgmetsaapseaapasaslvasQKtsStDL
Strongylocentrotus_purpuratus SpPkkmKTdngiKagg-EpvSltsdc-----nEngEsEE----dtsp------qplprlvirQRvpSgEL
Xenopus_laevis                SsPtneESpkktKtee-De-NdssnstevdeqNklEtEElkevhseekssspvpga--lpssQRssStDL
Xenopus_tropicalis            hpPcleDSpkriRdte-mllglpeptfiepsvpheEerQqsgeniipagampiptidr-srsQRlpSkEL
====================================================================================================
Consensus                     sxpxxxesxxxxkxxxxexxsxxxxxxxxxxxdxxexeexxxxxxxxxxxxxxxxxxxxxxxqkxxsxdl

                                     920       930       940       950       960       970       980
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     xdixxxlpxxxxxxvxknsiklxln
=======================================================
YEAST                         -------------------------
Candida_glabrata              -------------------------
Eremothecium_gossypii         -------------------------
Kluyveromyces_lactis          -------------------------
=======================================================
BOVINE                        sDIpa-LPanp-ipViKNSIKLrLN
Apis_mellifera                -------------------------
Canis_lupus                   sDIpa-LPanp-ipViKNSIKLrLN
Danio_rerio                   sDVpv-LPsnp-ipVvKNSIKLrLS
Drosophila_melanogaster       -------------------------
Gallus_gallus                 sDIpa-LPanp-ipViKNSIKLrLN
Homo_sapiens                  sDIp---------------------
Mus_musculus                  sDIpa-LPanp-ipViKNSIKLrLN
Rattus_norvegicus             sDIpa-LPanp-ipViKNSIKLrLN
Strongylocentrotus_purpuratus pDMaspLPvapkapIaKNTIRLnLN
Xenopus_laevis                sDIsv-LPatp-ipViKNSIKLrLN
Xenopus_tropicalis            pDssspVPtnn-irViKNSIRLtLN
=======================================================
Consensus                     xdixxxlpxxxxxxvxknsiklxln