10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxaxakxdnlslvlhgpgdlrlxxxxxxxxxxxxxxxxxxxxxxxenxpipexx ================================================================================================= 1E3JA.BEMISIA_ARGENTIFOLII ---------------------asDNLSaVLykqnDLRL-----------------------EqrPIPE-- ================================================================================================= HUMAN -----------------aAaAKpNNLSLVVHGPGDLRL-----------------------ENyPIPE-- Bos_taurus ------------------AaAKpENLSLVVHGPGDLRL-----------------------ENyPIPE-- Canis_lupus ------------------AaAKaENLTLVVHGPGDLRL-----------------------ENyPIPE-- Danio_rerio ---------------------------------------------------------------------- Gallus_gallus -------------------aAtgqNLaVVVHraGDLRL-----------------------ENrPIPE-- Mus_musculus -----------------aApAKgENLSLVVHGPGDIRL-----------------------ENyPIPE-- Ovis_aries ------------------AkpaaENLSLVVHGPGDLRL-----------------------ENyPIPE-- Pan_troglodytes -----------------aAaAKpNNLSLVVHGPGDLRLtlpfapwlvapkfrkwlsqqpshakaPLtKsl Pongo_pygmaeus -----------------aAaAKpsNLSLVVHGPGDLRL-----------------------ENyPIPE-- Rattus_norvegicus tssppdpadtskqesdmaApAKgENLSLVVHGPGDIRL-----------------------ENyPIPE-- Xenopus_laevis aas--------------kpsvEgENLSVVVHGiGDLRL-----------------------ENrPVPE-- Xenopus_tropicalis ------aan--------kpsvEgENLSVVVHGiGDLRL-----------------------ENrPVPE-- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxaxakxdnlslvlhgpgdlrlxxxxxxxxxxxxxxxxxxxxxxxenxpipexx 80 90 100 110 120 130 140 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xpgpnxxxevllqmhsVGICGSDVHYYEhGRIgDFIVKqPMVIGHEAsGtVvKVGxxVkhlKxxxxxxxx ================================================================================================= 1E3JA.BEMISIA_ARGENTIFOLII -PkeD---EVLLQMayVGICGSDVHYYEHGRIaDFIVKdPMVIGHEASGTVVKVGknVKHLK-------- ================================================================================================= HUMAN -PGPN---EVLLRMHSVGICGSDVHYWEyGRIGNFIVKKPMVLGHEASGTVeKVGssVKHLK-------- Bos_taurus -PGPN---EVLLKMHSVGICGSDVHYWQHGRIGDFVVKKPMVLGHEASGTVVKVGslVRHLQ-------- Canis_lupus -PGPN---EVLLKMHSVGICGSDVHYWQHGRIGDFIVKKPMVLGHEASGTVVKVGslVKHLK-------- Danio_rerio --------------HSVGICGSDVHYWQNGRIGDFVVKQPMILGHEASGrVVKVGsaVtHLK-------- Gallus_gallus -PGPN---EVLLRMHSVGICGSDVHYWQHGRIGDFVVKdPMVLGHEASGTVIKVGagVtHLK-------- Mus_musculus -lGPN---DVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAaGTVtKVGelVKHLK-------- Ovis_aries -PGPN---EVLLKMHSVGICGSDVHYWQ-GRIGDFVVKKPMVLGHEASGTVVKVGslVRHLQ-------- Pan_troglodytes sdGPgmavEVLLRMHSVGICGSDVHYWEyGRIGNFIVKKPMVLGHEASGTVeKVGssVgkqRtrpksgqt Pongo_pygmaeus -PGPN---EVLLRMHSVGICGSDVHYWEdGRIGNFIVKKPMVLGHEASGTVeKVGslVKHLK-------- Rattus_norvegicus -lGPN---DVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAaGTVtKVGpmVKHLK-------- Xenopus_laevis -PGPN---EVLLKMHSVGICGSDVHYWQHGRIGDFIVKKPMVLGHEASGTVVKVGasVsHLK-------- Xenopus_tropicalis -PGPN---EVLLKMHSVGICGSDVHYWQHGRIGDFIVKKPMVLGHEASGTVVKVGasVsHLK-------- ================================================================================================= Consensus xpgpnxxxevllqmhsVGICGSDVHYYEhGRIgDFIVKqPMVIGHEAsGtVvKVGxxVkhlKxxxxxxxx 150 160 170 180 190 200 210 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxpGDRVAVEPGxprQxdQFcKmGrYNLsPsLfFCATPPDDGNLcRYYkHsAnFCykL ================================================================================================= 1E3JA.BEMISIA_ARGENTIFOLII --------------kGDRVAVEPGvPcRrcQFCKeGKYNLcPdLtFCATPPDDGNLaRYYvHaADFChKL ================================================================================================= HUMAN --------------PGDRVAIEPGaPREnDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAaFCYKL Bos_taurus --------------PGDRVAIEPGaPREtDEFCKIGRYNLSPTIFFCATPPDDGNLCRFYKHNANFCYKL Canis_lupus --------------sGDRVAIEPGalREmDEFCKIGRYNLSPSIFFCATPPDDGNLCQFYKHNADFCYKL Danio_rerio --------------PGDRVAVEPGvPREvDEFvKsGhYNLSPSIFFCATPPDDGNLCRYYKHSASFCYKL Gallus_gallus --------------PGDRVAIEPGvPREtDEFCKtGRYNLSPTIFFCATPPDDGNLCRYYKHSASYCYKL Mus_musculus --------------PGDRVAIEPGvPREvDEYCKIGRYNLTPTIFFCATPPDDGNLCRFYKHNADFCYKL Ovis_aries --------------PGDRVAIQPGaPRQtDEFCKIGRYNLSPTIFFCATPPDDGNLCRFYKHNANFCYKL Pan_troglodytes llppsdmvpslfssPGDRVAIEPGaPREnDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAaFCYnI Pongo_pygmaeus --------------PGDRVAIEPGaPREnDEFCKIGRYNLSPSIFFCATPPDDGNLCRFYKHNAaFCYKL Rattus_norvegicus --------------PGDRVAIEPGvPREiDEFCKIGRYNLTPSIFFCATPPDDGNLCRFYKHSADFCYKL Xenopus_laevis --------------PGDRVAIEPGvPREtDEFCKMGRYNLSPTIFFCATPPDDGNLCRYYtHNANFCYKL Xenopus_tropicalis --------------PGDRVAIEPGvPREtDEFCKMGRYNLSPTIFFCATPPDDGNLCRYYtHNANFCYKL ================================================================================================= Consensus xxxxxxxxxxxxxxpGDRVAVEPGxprQxdQFcKmGrYNLsPsLfFCATPPDDGNLcRYYkHsAnFCykL 220 230 240 250 260 270 280 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxPDNVSfEEGALLEPLSVGVhACRRagVsLGnkVlVcGaGPIGLVSVLvAKamGA ================================================================================================= 1E3JA.BEMISIA_ARGENTIFOLII ----------------PDNVSlEEGALLEPLSVGVHACRRAGVqLGttVLViGAGPIGLVSVLaAKAyGA ================================================================================================= HUMAN ----------------PDNVTFEEGALIEPLSVGIHACRRgGVTLGHKVLVCGAGPIGMVTLLVAKAMGA Bos_taurus ----------------PDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGLVSLLaAKAMGA Canis_lupus ----------------PDNVTYEEGALIEPLSVGIHACRRAGITLGNKVLVCGAGPIGLVTLIVAKAMGA Danio_rerio ----------------PDNVTYEEGALIEPLSVGIHACRRAGVTLGSsVfVCGAGPIGLVSLLaAKAMGA Gallus_gallus ----------------PDSVTFEEGALIEPLSVGIHACKRAGVTLGSRVfVsGsGPIGLVNVIIAKmMGA Mus_musculus ----------------PDSVTFEEGALIEPLSVGIyACRRgsVSLGNKVLVCGAGPVGMVTLLVAKAMGA Ovis_aries ----------------PDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGLVNLLaAKAMGA Pan_troglodytes vvnsedlcvsidssgfPDNVTFEEGALIEPLSVGIHACRRgGVTLGHKVLVCGAGPIGMVTLLVAKAMGA Pongo_pygmaeus ----------------PDNVTFEEGAMIEPLSVGIHACRRgGVTLGHKVLVCGAGPIGMVTLLVAKAMGA Rattus_norvegicus ----------------PDSVTFEEGALIEPLSVGIyACRRgsVSLGNKVLVCGAGPIGIVTLLVAKAMGA Xenopus_laevis ----------------PDNVTFEEGALIEPLSVGIHACRRAGVTLGSRVfICGAGPIGLVSLLVAKmMGA Xenopus_tropicalis ----------------PDNVTFEEGALIEPLSVGIHACRRAGVTLGSRVfICGAGPIGLVSLLVAKmMGA ================================================================================================= Consensus xxxxxxxxxxxxxxxxPDNVSfEEGALLEPLSVGVhACRRagVsLGnkVlVcGaGPIGLVSVLvAKamGA 290 300 310 320 330 340 350 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xqVVvtdlSasrLxxxxxkaKeiGADfvLqVxxxkExspqeIakRIexlIGxkPevtIDCSGxEssIqag ================================================================================================= 1E3JA.BEMISIA_ARGENTIFOLII -fVVcTarSprRL----evAKncGADvtLvVdpaKE-eessIiERIrsaIGdlPnVTIDCSGnEkcItiG ================================================================================================= HUMAN aQVVVTDLSATRL----sKAKEIGADlVLQIs--KE-SPQEIARKVEgqLGcKPEVTIECTGaEaSIQAG Bos_taurus aQVVVTDLSASRL----sKAKEVGADFILQIs--nE-SPQEIAKKVEgLLGsKPEVTIECTGvETSIQAG Canis_lupus gQVLVTDLSASRL----sKAKEVGADiVLQIs--KE-SPKEIAsKVEdMLGcKPEaTIECTGvESaIQsG Danio_rerio sQVIISDLSsdRL----aKAKEIGADFLLpVk--KEdSPQDLAKRVEgMLGcmPQIcIECTGvQSSIQta Gallus_gallus aaVVVTDLSASRL----qtAKELGADFtIQIk--nE-TPQEVAaKVEsLLGcmPEITVECTGvQacIQAs Mus_musculus aQVVVTDLSASRL----tKAKEVGADFtIQVg--KE-TPQEIAsKVEsLLGsKPEVTIECTGaESSVQtG Ovis_aries aQVVVTDLSASRL----sKAKEVGADFILEIs--nE-SPEEIAKKVEgLLGsKPEVTIECTGvETSIQAG Pan_troglodytes aQVVVTgkTlSvLlpdcpKpKEIGADlVLQIs--KE-SPQEIARKVEgLLGcKPEVTMECTGaETSIQAG Pongo_pygmaeus aQVVVTDLSATRL----sKAKEIGADlVLQIs--KE-SPQEIARKVEgLLGcKPEVTIECTGaEaSIQAG Rattus_norvegicus sQVVViDLSASRL----aKAKEVGADFtIQVa--KE-TPhDIAKKVEsVLGsKPEVTIECTGaESSVQdG Xenopus_laevis sQVVISDLSlSRL----eKAKELGADFVVQVa--tE-pPEvIARKVEeLLGtmPEITIECTGaEScIQAG Xenopus_tropicalis sQVVISDLSlpRL----eKAKELGADFVVQVt--tE-aPEvIAQKVEkLLGimPEITIECTGaEScIQAG ================================================================================================= Consensus xqVVvtdlSasrLxxxxxkaKeiGADfvLqVxxxkExspqeIakRIexlIGxkPevtIDCSGxEssIqag 360 370 380 390 400 410 420 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus IyaTrsGGtLMlVGMGxqMxSVPLvNAaiREIDIKgVFRYCNtYPIALsMVaSkxvNVkpLVTHrFpLEq ================================================================================================= 1E3JA.BEMISIA_ARGENTIFOLII IniTRTGGTLMLVGMGsQMvTVPLVNAcaREIDIKsVFRYCNdYPIALeMVASgrcNVKqLVTHsFkLEQ ================================================================================================= HUMAN IYATRSGGTLVLVGLGsEMtTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKsVNVKPLVTHRFPLEK Bos_taurus IYAThSGGTLVLVGLGsEMtSVPLVHAAtREVDIKGVFRYCNTWPMAISMLASKsVNVKPLVTHRFPLEK Canis_lupus IYATRaGGTLVLVGLGsEMtTVPLtHAstREVDIKGVFRYCNTWPMAISMLASKaVNVKPLVTHRFPLEK Danio_rerio IYATRSGGvVVsVGLGaEMtTVPLLNAAVREVDIRGVFRYCNTWPVAISMLASKkVNVKPLVTHRFPLEh Gallus_gallus IYATRSGGTLVLVGLGpEMvTVPIVNAAVREVDIRGIFRYCNTWPVAISLLASKrINIKPLVTHRFPLEK Mus_musculus IYAThSGGTLVIVGMGaEMvNLPLVHAAIREVDIKGVFRYCNTWPMAISMLASKtLNVKPLVTHRFPLEK Ovis_aries IYAThSGGTLVLVGLGsEMtSVPLVHAAtREVDIKGVFRYCNTWPMAISMLASKsVNVKPLVTHRFPLEK Pan_troglodytes IYATRSGGTLVLVGLGsEMtTVPLLHAAVREVDIKGVFRYCNTWPVAISMLASKsVNVKPLVTHRFPLEK Pongo_pygmaeus IYAThSGGTLVLVGLGsEMtTIPLLHAAIREVDIKGVFRYCNTWPVAISMLASKsVNVKPLITHRFPLEK Rattus_norvegicus IYAThSGGTLVVVGMGpEMiNLPLVHAAVREVDIKGVFRYCNTWPMAVSMLASKtLNVKPLVTHRFPLEK Xenopus_laevis IYATRSGGTLILVGLGpaMvNVPIVNAAVREVDIRGIFRYCNTWPMAISMLsSKrVNVaPLVTHRFPLEK Xenopus_tropicalis IYATRSGGTLILVGLGpaMvNVPIVNAAVREVDIRGIFRYCNTWPMAISMLsSKrVNVaPLVTHRFPLEn ================================================================================================= Consensus IyaTrsGGtLMlVGMGxqMxSVPLvNAaiREIDIKgVFRYCNtYPIALsMVaSkxvNVkpLVTHrFpLEq 430 440 450 460 470 480 490 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus avEAFEtxrkglxxgIKVMIkCdpsdqnp ======================================================== 1E3JA.BEMISIA_ARGENTIFOLII tVDAFEaaRKkadntIKVMIsCrqg---- ======================================================== HUMAN ALEAFETfKKGL--GLKIMLKCDPSDQNP Bos_taurus ALEAFETsKKGL--GLKVMIKCDPNDQNP Canis_lupus ALEAFETaRKGt--GLKVMLKCDPNDQNP Danio_rerio AVQAFETtRQGL--GVKVMLKCDkNDQNP Gallus_gallus ALEAFETtKRGe--GVKIMLKCDPTDQNP Mus_musculus AVEAFETaKKGV--GLKVMIKCDPNDQNP Ovis_aries ALEAFETsKKGL--GLKVMIKCDPSDQNP Pan_troglodytes ALEAFETfKKGL--GLKIMIKCDPNDQNP Pongo_pygmaeus ALEAFETfKKGL--GLKIMLKCDPNDQNP Rattus_norvegicus AVEAFETaKKGL--GLKVMIKCDPNDQNP Xenopus_laevis AVEAFETtKKGV--GVKVMLKCDkNDQeP Xenopus_tropicalis AaEAFETtKKGM--GVKVMLKCDkNDQNP ======================================================== Consensus avEAFEtxrkglxxgIKVMIkCdpsdqnp