10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xaxRRLxKELEEIRENxmkNxxxnixVNEsNLlxwQGxiVxxdxxPYDkGaFRIEInfPxEYPFKPPKIxFkTKI ==================================================================================================== HUMAN aAsRRLmKELEEIRKcgMKN-frNIqVDEaNLLtWQGlIVp-DnpPYDKGAFRIEINFPaEYPFKPPKItFKTKI Anopheles_gambiae aAtRRLqKELaDIRsSgMKS-frDIlVDETNLLlWtGlIVp-DnvPYNKGAFRIEINFPaEYPFKPPKIsFKTKI Apis_mellifera aAtRRLqKELgDLRaSaMKN-ftNIqVDESNILtWQGlILp-DnpPYNKGAFRIEINFPaEYPFKPPKInFKTKI Danio_rerio aAsRRLhKELDEIRKSgMKN-frNIqVDESNILtWQGlIVp-DnpPYDKGAFRIEItFPaEYPFKPPKItFKTKI Drosophila_melanogaster tApRRLrKELsDLQgNaLKS-frDIkaDDdNLLrWtGlIVp-DnpPYNKGAFRIEINFPaEYPFKPPKInFKTRI Drosophila_pseudoobscura tApRRLrKELcDLQDNtLKS-frDIkaDDeNLLrWtGlIVp-DnpPYNKGAFRIEINFPaEYPFKPPKInFKTRI Pan_troglodytes aAsRRLmKELEEIRKcgMKN-frNIqVDEaNLLtWQGlIVp-DnpPYDKGAFRIEINFPaEYPFKPlKItFKTKI Pongo_pygmaeus aAsRRLmKELEEIRKcgMKN-frNIrVDEaNLLtWQGlIVp-DnpPYDKGAFRIEINFPaEYPFKPPKItFKTKI Schistosoma_japonicum aAvRRLkKEyEtLinSsIKNvirNVtyDEpNfLtWtGyIVl-DepPYNKGAFKIEItFPvEYPFKPPKViFKTRI Tetraodon_nigroviridis sAsRRLaKELEEIRKSgMKN-frNIqVeESNLLsWQGlIVp-DnpPYDKGAFRIEIiFPtEYPFKPPKItFKTKI ==================================================================================================== YEAST sraKRImKEIQaVKDDpaaH-itlefVSESDIhhlKGtfLgppgtPYEgGkFvVDIevPmEYPFKPPKMqFdTKV Candida_albicans srvKRIaKELEEcRQDtqsg-vslnlnNENDLthltGyfkgppgtPYEgGlFQVaIDiPqEYPFKPPQMkFiTKI Candida_glabrata sraKRImKELQaVKDDpeaN-islefVSESDIhhlKGsfLgppgtPYEgGkFiVDIevPmEYPFKPPKMkFdSKV Debaryomyces_hansenii srvRRIaKELEEcgQDtqsg-vslqlVNETDLthlsGffrgppgtPYEgGlFQVDINiPnEYPFKPPQMkFaTKI Eremothecium_gossypii sraKRLmKEIQsVKDDpdaN-islafVSESDIhhlKGtfLgppgtPYhgGtFiVDIqvPlEYPFKPPKMqFdTKV Kluyveromyces_lactis lrsKRIlKEIQaVKEDpeaq-ielkfVNESDIhhmKGsfIgpsgtPYEgGkFvVDINiPvEYPYKPPQMkFdTKV Yarrowia_lipolytica sraRRVaREMEDVRsDseag-itiqaINDaDIshlKGtfhgppgtPYqgGtFvVDIqiPnDYPFKPPRMkFdTRI ==================================================================================================== Consensus xaxRRLxKELEEIRENxmkNxxxnixVNEsNLlxwQGxiVxxdxxPYDkGaFRIEInfPxEYPFKPPKIxFkTKI 80 90 100 110 120 130 140 150 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus YHPNIdexkGqVCLpVIsxDSWkPatkxExvIqSLiALVnxPQPehPlrAELAEeYLKDRKkFxKnAeEYTKKYx ==================================================================================================== HUMAN YHPNIDE-KGQVCLPVISaENWKPATKtDqVIQSLIALVNdPQPEHPLRADLAEEYsKDRKKFcKNAEEFTKKYg Anopheles_gambiae YHPNIDE-KGQVCLPIISaENWKPATKtDqVIQaLIeLVNdPEPEHPLRADLAEEFLKDRKKFtKNAEEhTRKhs Apis_mellifera YHPNVDE-KGQVCLPIISaENWKPATKtDqVVQaLIALVNdPEPEHPLRADLAEEFLKDRKKFlKNAEEFTKKha Danio_rerio YHPNIDE-KGQVCLPVISaENWKPATKtDqVIQSLIALVNdPQPEHPLRADLAEEYsKDRKKFfKNAEEFTKKhg Drosophila_melanogaster YHPNIDE-KGQVCLPIIStENWKPATRtDqVVQaLVdLINdPEPEHPLRAELAEEFLKDRKKFvKNAEDYTKKhs Drosophila_pseudoobscura YHPNIDE-KGQVCLPIIStENWKPATRtEqVVQaLIALINdPEPEHPLRAELAEEFLKDRKKFvKNAEDYTKKhs Pan_troglodytes YHPNIDE-KGQVCLPVISaENWKPATKtDqVIQSLIALVNdPQPEHPLRADLAEEYsKDRKKFcKNAEEFTKKYg Pongo_pygmaeus YHPNIDE-KGQVCLPVISaENWKPATKtDqVIQSLIALVNdPQPEHPLRADLAEEYsKDRKKFcKNAEEFTKKYg Schistosoma_japonicum YHPNIDE-KGQICLPIINpENWKPATKvEhVIQaLVAMLHaPEvEHaLRsDLAEEYaKDpKKFfKNAEEFTRKYa Tetraodon_nigroviridis YHPNIDE-KGQVCLPVISaENWKPATKtDqVIQSLIALVNdPQPEHPLRADLAEEYsKDRKKFlKNAEEFTKKhg ==================================================================================================== YEAST YHPNIssvtGaICLdILk-NaWsPvitlKsaLiSLqALLqsPEPndPqdAEVAQhYLRDREsFnKtAalWTRlYa Candida_albicans YHPNIssvtGaICLdILk-DaWtPiltlKssLiSLqsLLqsPEPsdPqdAEVAKhYLsNKsgFeEtAayWTKiYa Candida_glabrata YHPNIssvtGaICLdILk-NaWsPvitlKsaLiSLqALLqsPEPndPqdAEVAQhYLRDRQsFdKtAalWTKlYa Debaryomyces_hansenii YHPNIssvtGaICLdILk-DaWtPiltlKssLiSLqsLLqsPEPndPqdAEVAKhYLtNKKgFeEtAtyWTKiYa Eremothecium_gossypii YHPNIssvtGaICLdILk-NSWsPvltlKtsLiSLqALLqsPEPndPqdAEVAKhYLsDRasFdRtAalWTKtYa Kluyveromyces_lactis YHPNVssvtGaICLdILk-NaWtPvitlKsaLiSLqALLqsPEPndPqdAQVAKhYLtDKKsFdEtAalWTRtYa Yarrowia_lipolytica YHPNIssqtGaICLdILk-DaWsPvftlKssLiSLqsLLqsaEPndPqdAEVAKiYLtDKaaFeRtAaEWTaQYa ==================================================================================================== Consensus YHPNIdexkGqVCLpVIsxDSWkPatkxExvIqSLiALVnxPQPehPlrAELAEeYLKDRKkFxKnAeEYTKKYx 160 170 180 190 200 210 220 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus eexxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== HUMAN EKrpvd--------------------------------------------------------------------- Anopheles_gambiae EKrpe---------------------------------------------------------------------- Apis_mellifera EKrresssne----------------------------------------------------------------- Danio_rerio EKrpvd--------------------------------------------------------------------- Drosophila_melanogaster EKrpad--------------------------------------------------------------------- Drosophila_pseudoobscura EKrpad--------------------------------------------------------------------- Pan_troglodytes EKrpvd--------------------------------------------------------------------- Pongo_pygmaeus EKrpvd--------------------------------------------------------------------- Schistosoma_japonicum EKipnl--------------------------------------------------------------------- Tetraodon_nigroviridis EKrpmd--------------------------------------------------------------------- ==================================================================================================== YEAST sE------------t--sngq----kg------nveesdlygidhdlidefesqgfekdkivevlrrlgvksld- Candida_albicans sDgvdgsgsgsgssn--nngg----ga------klsdsalygiddeivgqyesmgfprdktiqvlrrmgiksfkg Candida_glabrata sa------------e--gsgd------------svdeaqlygidpeivkefesqgfeknkivealrrlgvksld- Debaryomyces_hansenii sD------------g--dkag----ks------dlsdsalygidddivtqfenmgfprdktievlrrmgvksfng Eremothecium_gossypii s------------------gq----tg------ndeeaqlygidkglvdtlvaqgferekvvqalrrlgiktmd- Kluyveromyces_lactis ss------------nggdngtnslgkgteenvqeldeadlygidqdlvtqfvnqgfdrqnvievlkrlniksms- Yarrowia_lipolytica gg------------n--aggd----qd------eiar---lgldrdavegfasmgfgkdkiiavfkklqik--k- ==================================================================================================== Consensus eexxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 230 240 250 260 270 280 290 300 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxx ============================================= HUMAN -------------------- Anopheles_gambiae -------------------- Apis_mellifera -------------------- Danio_rerio -------------------- Drosophila_melanogaster -------------------- Drosophila_pseudoobscura -------------------- Pan_troglodytes -------------------- Pongo_pygmaeus -------------------- Schistosoma_japonicum -------------------- Tetraodon_nigroviridis -------------------- ============================================= YEAST -pndnntanriieellk--- Candida_albicans vgnkselenkileellrecq Candida_glabrata -pndnatvnkiieellk--- Debaryomyces_hansenii vsnksdlenkileellrecq Eremothecium_gossypii -kgdnekaniileellk--- Kluyveromyces_lactis -mednetankileellke-- Yarrowia_lipolytica -pqsqedeqrvveelln--- ============================================= Consensus xxxxxxxxxxxxxxxxxxxx