eIF2a

                                     220       230       240       250       260       270       280
                              ----:----|----:----|----:----|----:----|----:----|----:----|----:----|
Consensus                     gidaikkalxxaexxnsxexxvkxkllxaplfvvsstxldexxgixxvxeaixxvxkxixexxgxvxixm
====================================================================================================
HUMAN                         egidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVlsqamaViKekiEekrgVfnvq
Bombyx_mandarina              egidavRAalkAglalStvdmpikinLiAPplyVmTTstpEktdglkalQdaidkiQeniteaGgVfniq
Danio_rerio                   egidavKealrAglncStEampikinLiAPpryVmTTttlErteglsVlnqamaaiKeriEekrgVfnvq
Gallus_gallus                 egidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVlnqamaViKekiEekrgVfnvq
Oncorhynchus_mykiss           egidavKdalrAglscStEampikinLiAPpryVmTTttlErteglsVlnqamaaiKeriEekrgVfniq
Pongo_pygmaeus                egidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVlsqamaViKekiEekrgVfnvq
Rattus_norvegicus             egidavKealrAglncStEtmpikinLiAPpryVmTTttlErteglsVlnqamaViKekiEekrgVfnvq
Strongylocentrotus_purpuratus ---------ltkgldmSsEempikinLiAPpqyVvTTqtlErvegveklKeaieaiKesilksagVfkv-
Tetraodon_nigroviridis        dgidavKdalrAglscStDvmpikinLiAPpryVmTTttlErteglsVlnqamaaiKekiEekrgVfniq
Tribolium_castaneum           egidavKtalksglslStDelpikinLiAPplyVmTTstpEkqdglkIlndaiekiKatiselGgVfnvq
Xenopus_laevis                egidavKdalrAglscStEnmpikinLiAPpryVmTTttlErteglsVlnqamsViKeriEekrgVfnvq
Xenopus_tropicalis            egidavKdalrAglscStEnmpikinLiAPpryVmTTttlErteglsVlnqamsViKeriEekrgVfnvq
====================================================================================================
YEAST                         GIDAIKdALksAEdmSTeQmqVKvKLVaAPLYVLTTqaLDKqkGIeqLesAIekItEvItKygGvcnItM
Aspergillus_flavus            GIDAVKaALrtAEeaNTpDsqVKvKLVapPLYVLTSqcLDKaiGIkqLeEAIqrIeakIkEagGgcsVkM
Aspergillus_fumigatus         GIDAVKnALrtAEanNTpEnqIKvKLVapPLYVLTSqcLDKnlGIklLeEAIerIdseIkKagGgcvVkM
Candida_albicans              GIDAIKEALkaAEsvSTsQmqVKaKLVaAPLYfITvqaLDKneGVklLeKAIekItEsIeasgGnckVsM
Candida_glabrata              GIDAIKEALksAEdmSTeQmqIKvKLVaAPLYVLTTqaLDKqiGIdlLgKAIdkInEvIsKygGvcnItM
Chaetomium_globosum           GIDAIKtALrtAEarNTdEaqVKcRLVspPLYVLTNTcLDKnaGIarLeEAIvdVrtsIesagGnLvVkM
Coccidioides_immitis          GIDAVKEALrtAEanNTtDnqVKvKLVspPLYVLTShcLDKnlGIktLeDAIkgItEkIrasgGscvVqM
Cryptococcus_neoformans       GIDAIKRALtagEavSTpDvpIKvRLVapPLYVMSTTstDKnaaIelMeKAVevIgEtVrKdkGdItIkM
Debaryomyces_hansenii         GIDAIKKALtaAEeiSTeQmaVKaKLVaAPLYVISvqaLDKnqGIalLeKAIekVsEsIensgGickVtM
Emericella_nidulans           GIDAVKnALrtAEaeNTpEnqIKvKLVapPLYVLTSqcLDKthGIkmLeEAIerIettIkasgGgctVkM
Eremothecium_gossypii         GIEAIKEALkaAEatSTeQmqVKvKLVaAPLYVITTqaLDKnqGIeaLnhAIskIeEyIaKyqGvcnVtM
Gibberella_zeae               GIDAIKtALhtAEakNTeEtqVKvRLVspPLYVLNSTcLDKslGItrLqEAIvdIrasIeaagGhLtVkM
Kluyveromyces_lactis          GIDAIKEALksAEelSTeQmqIKvKLVaAPLYVITTqsLDKdqGVqlLetAIakIeEvIlKynGvcnVtM
Magnaporthe_grisea            GIDAIKtALrtAEsrNTqDnqVKvKLVspPLYVLTSTcLDKslGIarLeEAIvdIrtsIesagGkLiVkM
Neurospora_crassa             GIDAIKtALrtAEarNTeEtqVKcRLVspPLYVLTNTcLDKnaGIarLqEAIqdMrtsIeaagGhLvVkM
Schizosaccharomyces_pombe     GINAIKaALkaAEdvHTeEvpIKvKLVapPLYVLlTnaLDKslGLkkLeEAIgaIeKsItasnGtctVkM
Ustilago_maydis               GIDAVKKALragEavSTeaipIKiKLVapPLYVLiTnstDKvgGIalMeQALekItEsIrangGdVdIkM
Yarrowia_lipolytica           GIEAIKKALaagEtlNSelvpVKvKLVaAPLFVLTSTcLDKqkaIdtLgEAIekIrEsIeasgGsLtVkM
====================================================================================================
Consensus                     gidaikkalxxaexxnsxexxvkxkllxaplfvvsstxldexxgixxvxeaixxvxkxixexxgxvxixm

Page 4 of 9